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    MUP3 Mup3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856349, updated on 17-May-2024

    Summary

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    Gene symbol
    MUP3
    Gene description
    Mup3p
    Primary source
    FungiDB:YHL036W
    Locus tag
    YHL036W
    See related
    SGD:S000001028; AllianceGenome:SGD:S000001028; VEuPathDB:YHL036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-methionine transmembrane transporter activity. Involved in methionine import across plasma membrane. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in cystinuria and lysinuric protein intolerance. Orthologous to several human genes including SLC7A10 (solute carrier family 7 member 10); SLC7A11 (solute carrier family 7 member 11); and SLC7A13 (solute carrier family 7 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MUP3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (26241..27881)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Cbp2p Neighboring gene uncharacterized protein Neighboring gene putative ATP-binding cassette multidrug transporter VMR1 Neighboring gene Sbp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases. Isnard AD, et al. J Mol Biol, 1996 Oct 4. PMID 8893857
    2. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Shimada K, et al. Mol Cell, 2013 Sep 26. PMID 24035500
    3. Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake. dos Santos SC, et al. Antimicrob Agents Chemother, 2009 Dec. PMID 19805573, Free PMC Article
    4. Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs. Holmes KJ, et al. PLoS One, 2013. PMID 24386330, Free PMC Article
    5. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. Figley MD, et al. J Neurosci, 2014 Jun 11. PMID 24920614, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-methionine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in methionine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mup3p
    NP_011827.1
    • Low affinity methionine permease; similar to Mup1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      26241..27881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179116.1 → NP_011827.1  TPA: Mup3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011827.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT2, P38734
      UniProtKB/TrEMBL
      A0A7I9F1D9, A6ZSL4, B3LS83, B5VJP0, C8ZA26, G2WF29, N1P545
      Conserved Domains (1) summary
      TIGR00911
      Location:40 → 538
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38734.1

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