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    ARN2 siderophore transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856338, updated on 17-May-2024

    Summary

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    Gene symbol
    ARN2
    Gene description
    siderophore transporter
    Primary source
    FungiDB:YHL047C
    Locus tag
    YHL047C
    See related
    SGD:S000001039; AllianceGenome:SGD:S000001039; VEuPathDB:YHL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TAF1
    Summary
    Enables siderophore transmembrane transporter activity. Involved in cellular iron ion homeostasis; siderophore metabolic process; and siderophore transport. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARN2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (8351..10213, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cos8p Neighboring gene seripauperin PAU13 Neighboring gene Pxp3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Siderophore uptake and use by the yeast Saccharomyces cerevisiae. Lesuisse E, et al. Microbiology (Reading), 2001 Feb. PMID 11158346
    2. Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily. Heymann P, et al. Biometals, 1999 Dec. PMID 10816729
    3. MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast. Pupo A, et al. Biol Trace Elem Res, 2020 May. PMID 31392542, Free PMC Article
    4. Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Emerson LR, et al. Antimicrob Agents Chemother, 2002 Mar. PMID 11850263, Free PMC Article
    5. New and efficient method using Saccharomyces cerevisiae mutants for identification of siderophores produced by microorganisms. Park YS, et al. Curr Genet, 2007 Sep. PMID 17665200

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables siderophore-iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables siderophore-iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables siderophore-iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siderophore transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    siderophore transporter
    NP_011816.2
    • Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      8351..10213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179127.2 → NP_011816.2  TPA: siderophore transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011816.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKS4, P38724
      UniProtKB/TrEMBL
      A0A8H4BZI1, B5VJN3
      Conserved Domains (1) summary
      cd17322
      Location:69 → 581
      MFS_ARN_like; Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38724.2

    Gene LinkOut

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