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    MAK16 ribosome biosynthesis protein MAK16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851208, updated on 7-Jul-2024

    Summary

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    Gene symbol
    MAK16
    Gene description
    ribosome biosynthesis protein MAK16
    Primary source
    FungiDB:YAL025C
    Locus tag
    YAL025C
    See related
    SGD:S000000023; AllianceGenome:SGD:S000000023; VEuPathDB:YAL025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human MAK16 (MAK16 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MAK16 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (100225..101145, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene DNA-binding protein SAW1 Neighboring gene aminophospholipid-translocating P4-type ATPase DRS2 Neighboring gene ncRNA Neighboring gene mitotic regulator LTE1 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mak16p is required for the maturation of 25S and 5.8S rRNAs in the yeast Saccharomyces cerevisiae. Pellett S, et al. Yeast, 2006 May. PMID 16710831
    2. SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets protein transport to the nucleolus. Milhon JL, et al. Mol Biochem Parasitol, 2000 May. PMID 10838225
    3. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation of the MAK16 gene and analysis of an adjacent gene essential for growth at low temperatures. Wickner RB, et al. Yeast, 1987 Mar. PMID 3332963
    4. Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae. Wickner RB. Proc Natl Acad Sci U S A, 1988 Aug. PMID 3045810, Free PMC Article
    5. Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Icho T, et al. Basic Life Sci, 1986. PMID 3551912

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mak16p is required for the maturation of 25S and 5.8S rRNAs in Saccharomyces cerevisiae.
      Title: Mak16p is required for the maturation of 25S and 5.8S rRNAs in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome biosynthesis protein MAK16
    NP_009377.2
    • Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      100225..101145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178170.2 → NP_009377.2  TPA: ribosome biosynthesis protein MAK16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009377.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPJ3, P10962
      UniProtKB/TrEMBL
      A0A6A5PV78, A7A0E3, B3LUV9, B5VDJ6, C7GPL0, C8Z3K2, G2W8K7, N1P8W4
      Conserved Domains (1) summary
      COG5129
      Location:1 → 306
      MAK16; Nuclear protein with HMG-like acidic region [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10962.2

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