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    EIF3B eukaryotic translation initiation factor 3 subunit B [ Homo sapiens (human) ]

    Gene ID: 8662, updated on 3-Nov-2024

    Summary

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    Official Symbol
    EIF3Bprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Bprovided by HGNC
    Primary source
    HGNC:HGNC:3280
    See related
    Ensembl:ENSG00000106263 MIM:603917; AllianceGenome:HGNC:3280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116
    Summary
    Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF3B in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (2354086..2380745)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (2467574..2494152)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2393721..2420380)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2297547-2298326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2298327-2299106 Neighboring gene microRNA 6836 Neighboring gene sorting nexin 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2309692-2310302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2310912-2311521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2311522-2312130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25520 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25521 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2340879-2341379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2341882-2342382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2349114-2349623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2349624-2350134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2350135-2350643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2354180-2354680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2354681-2355181 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2393253-2393808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2416395-2416894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2418983-2419483 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2429085-2429981 Neighboring gene kinesin family member 19B, pseudogene Neighboring gene NGRN pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. Chaudhuri J, et al. J Biol Chem, 1997 Dec 5. PMID 9388245
    2. Knockdown of eukaryotic translation initiation factors 3B (EIF3B) inhibits proliferation and promotes apoptosis in glioblastoma cells. Liang H, et al. Neurol Sci, 2012 Oct. PMID 22234522
    3. Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization. Wang H, et al. Clin Cancer Res, 2013 Jun 1. PMID 23575475, Free PMC Article
    4. Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway. Xu F, et al. Oncotarget, 2016 Jul 12. PMID 27270324, Free PMC Article
    5. EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer. Tian Y, et al. Cancer Biomark, 2018. PMID 30198870

    See all (237) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.
      Title: EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.
    2. EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.
      Title: EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.
    3. Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.
      Title: Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.
    4. EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.
      Title: EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.
    5. Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
      Title: Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
    6. Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
      Title: Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
    7. High EIF3B expression is associated with cervical cancer.
      Title: Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients.
    8. Inhibition of EIF3B gene expression significantly inhibit the proliferation of ovarian cancer cells and increase the apoptosis of ovarian cancer cells.
      Title: Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.
    9. EIF3B overexpression correlates with advanced disease conditions and poor prognosis, and it promotes cells proliferation while inhibits cells apoptosis in NSCLC.
      Title: EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer.
    10. Study demonstrated that EIF3B expression was up-regulated in esophageal squamous cell carcinoma cells and negatively correlated with the prognosis of patients.
      Title: Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with eIF3b in the cellullar cytoplasmic compartment PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104664, MGC131875

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational termination-reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit B
    Names
    eukaryotic translation initiation factor 3 subunit 9
    eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)
    eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa
    protein synthesis 1
    prt1 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037283.2 → NP_001032360.1  eukaryotic translation initiation factor 3 subunit B isoform 1

      See identical proteins and their annotated locations for NP_001032360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC004971, BQ045103, U78525
      Consensus CDS
      CCDS5332.1
      UniProtKB/Swiss-Prot
      A4D208, P55884, Q2NL77, Q9UMF9
      UniProtKB/TrEMBL
      B4DV79
      Related
      ENSP00000354125.4, ENST00000360876.9
      Conserved Domains (4) summary
      COG5354
      Location:305 → 805
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      PRK07764
      Location:4 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00039
      Location:376 → 423
      7WD40; WD40 repeat [structural motif]
      cd12278
      Location:184 → 264
      RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

    2. NM_001362791.2 → NP_001349720.1  eukaryotic translation initiation factor 3 subunit B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC004971, BC009986, U78525
      Consensus CDS
      CCDS5332.1
      UniProtKB/Swiss-Prot
      A4D208, P55884, Q2NL77, Q9UMF9
      UniProtKB/TrEMBL
      B4DV79
      Conserved Domains (4) summary
      COG5354
      Location:305 → 805
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      PRK07764
      Location:4 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00039
      Location:376 → 423
      7WD40; WD40 repeat [structural motif]
      cd12278
      Location:184 → 264
      RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

    3. NM_001362792.2 → NP_001349721.1  eukaryotic translation initiation factor 3 subunit B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004840, AC004971, BQ045103, DA781713
      UniProtKB/TrEMBL
      Q96G38
      Conserved Domains (2) summary
      COG5354
      Location:33 → 533
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      sd00039
      Location:104 → 151
      7WD40; WD40 repeat [structural motif]

    4. NM_001362793.2 → NP_001349722.1  eukaryotic translation initiation factor 3 subunit B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004840, AC004971, BQ045103, DA781713
      UniProtKB/TrEMBL
      Q96G38
      Conserved Domains (2) summary
      COG5354
      Location:33 → 533
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      sd00039
      Location:104 → 151
      7WD40; WD40 repeat [structural motif]

    5. NM_003751.4 → NP_003742.2  eukaryotic translation initiation factor 3 subunit B isoform 1

      See identical proteins and their annotated locations for NP_003742.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC004971, BQ015102, U78525
      Consensus CDS
      CCDS5332.1
      UniProtKB/Swiss-Prot
      A4D208, P55884, Q2NL77, Q9UMF9
      UniProtKB/TrEMBL
      B4DV79
      Related
      ENSP00000380206.2, ENST00000397011.2
      Conserved Domains (4) summary
      COG5354
      Location:305 → 805
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      PRK07764
      Location:4 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00039
      Location:376 → 423
      7WD40; WD40 repeat [structural motif]
      cd12278
      Location:184 → 264
      RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      2354086..2380745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515599.2 → XP_011513901.1  eukaryotic translation initiation factor 3 subunit B isoform X1

      See identical proteins and their annotated locations for XP_011513901.1

      UniProtKB/Swiss-Prot
      A4D208, P55884, Q2NL77, Q9UMF9
      UniProtKB/TrEMBL
      B4DV79
      Conserved Domains (4) summary
      COG5354
      Location:305 → 805
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      PRK07764
      Location:4 → 161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00039
      Location:376 → 423
      7WD40; WD40 repeat [structural motif]
      cd12278
      Location:184 → 264
      RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

    2. XM_047421000.1 → XP_047276956.1  eukaryotic translation initiation factor 3 subunit B isoform X2

      UniProtKB/TrEMBL
      A4D210

    3. XM_047421001.1 → XP_047276957.1  eukaryotic translation initiation factor 3 subunit B isoform X3

    4. XM_017012753.2 → XP_016868242.1  eukaryotic translation initiation factor 3 subunit B isoform X4

      UniProtKB/TrEMBL
      Q86UM1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      2467574..2494152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359283.1 → XP_054215258.1  eukaryotic translation initiation factor 3 subunit B isoform X3

    2. XM_054359282.1 → XP_054215257.1  eukaryotic translation initiation factor 3 subunit B isoform X2

    3. XM_054359281.1 → XP_054215256.1  eukaryotic translation initiation factor 3 subunit B isoform X1

    4. XM_054359284.1 → XP_054215259.1  eukaryotic translation initiation factor 3 subunit B isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182712.1: Suppressed sequence

      Description
      NM_182712.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55884.3 GenPept UniProtKB/Swiss-Prot:P55884

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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