ADPGK ADP dependent glucokinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADPGKprovided by HGNC
Official Full Name: ADP dependent glucokinaseprovided by HGNC
Primary source: HGNC:HGNC:25250
See related: Ensembl:ENSG00000159322 MIM:611861; AllianceGenome:HGNC:25250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADP-GK; 2610017G09Rik
Summary: ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (72751294..72783758, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (70568596..70601068, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (73043635..73076099, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.
Title: Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.
ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.
Title: ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.
ADP-dependent glucokinase as a novel onco-target for haematological malignancies.
Title: ADP-dependent glucokinase as a novel onco-target for haematological malignancies.
ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.
Title: ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.
ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose
Title: The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.
ADPGK can contribute to tumour cell survival under conditions of high glycolytic dependence.
Title: Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.
human ADPGK(ADP-dependent glucokinase) catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated.
Title: Expression and role in glycolysis of human ADP-dependent glucokinase.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Glucose and insulin response to oral glucose is higher in GCK(261) carriers, indicating clinical heterogeneity in GCK maturity diabetes carriers.
Title: Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).
The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of glucokinase, particularly if there is a positive family history.
Title: Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20332 (e-PCR)
- UniSTS:62997

A005M18 (e-PCR)
- UniSTS:62998

SHGC-132374 (e-PCR)
- UniSTS:170801

D8S2279 (e-PCR)
- UniSTS:473907

D15S838 (e-PCR)
- UniSTS:21357

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-24194 (e-PCR)
- UniSTS:69845

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ADP-specific glucokinase activity	EXP Inferred from Experiment more info	PubMed
enables ADP-specific glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-specific glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process through glucose-6-phosphate	TAS Traceable Author Statement more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: ADP-dependent glucokinase

Names: ATP-dependent glucokinase; rbBP-35

NP_001352152.1

EC 2.7.1.147

NP_001352153.1

EC 2.7.1.147

NP_001352154.1

EC 2.7.1.147

NP_001352155.1

EC 2.7.1.147

NP_001352156.1

EC 2.7.1.147

NP_001352157.1

EC 2.7.1.147

NP_001352158.1

EC 2.7.1.147

NP_112574.3

EC 2.7.1.147

XP_011520406.1

EC 2.7.1.147

XP_016878153.1

EC 2.7.1.147

XP_047289120.1

EC 2.7.1.147

XP_054234954.1

EC 2.7.1.147

XP_054234955.1

EC 2.7.1.147

XP_054234956.1

EC 2.7.1.147

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365223.1 → NP_001352152.1 ADP-dependent glucokinase isoform 2

Status: VALIDATED

Source sequence(s)

AC009712, AK075560, BC044589, DA031990, DA208247

UniProtKB/TrEMBL

B4DDP8

Conserved Domains (1) summary

cd01938
Location:1 → 369

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
NM_001365224.1 → NP_001352153.1 ADP-dependent glucokinase isoform 3

Status: VALIDATED

Source sequence(s)

AC009712, AK055526, AK075560

UniProtKB/TrEMBL

Q69YR1

Conserved Domains (1) summary

cl00192
Location:1 → 253

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_001365225.1 → NP_001352154.1 ADP-dependent glucokinase isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC009712, BC006112, DA031990

Consensus CDS

CCDS92041.1

UniProtKB/Swiss-Prot

Q49AU7, Q8NBI1, Q8WZ90, Q96NF8, Q9BRR6, Q9H0A7

UniProtKB/TrEMBL

B4DG35

Related

ENSP00000397694.3, ENST00000456471.3

Conserved Domains (1) summary

cd01938
Location:60 → 492

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
NM_001365226.1 → NP_001352155.1 ADP-dependent glucokinase isoform 5

Status: VALIDATED

Source sequence(s)

AC009712

UniProtKB/TrEMBL

B4DDP8

Conserved Domains (1) summary

cd01938
Location:1 → 370

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
NM_001365227.1 → NP_001352156.1 ADP-dependent glucokinase isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC009712, BI906568

Conserved Domains (1) summary

cl00192
Location:60 → 353

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_001365228.1 → NP_001352157.1 ADP-dependent glucokinase isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AC009712, DA600729

Conserved Domains (1) summary

cl00192
Location:60 → 352

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_001365229.1 → NP_001352158.1 ADP-dependent glucokinase isoform 3

Status: VALIDATED

Source sequence(s)

AC009712

UniProtKB/TrEMBL

Q69YR1

Conserved Domains (1) summary

cl00192
Location:1 → 253

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_031284.5 → NP_112574.3 ADP-dependent glucokinase isoform 1 precursor

See identical proteins and their annotated locations for NP_112574.3

Status: VALIDATED

Source sequence(s)

AC009712, AK075560, DA031990, DB279245

Consensus CDS

CCDS42057.1

UniProtKB/TrEMBL

B4DG35

Related

ENSP00000312250.8, ENST00000311669.12

Conserved Domains (1) summary

cd01938
Location:60 → 491

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

72751294..72783758 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522104.4 → XP_011520406.1 ADP-dependent glucokinase isoform X2

Conserved Domains (1) summary

cl00192
Location:60 → 313

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_047433164.1 → XP_047289120.1 ADP-dependent glucokinase isoform X1
XM_017022664.3 → XP_016878153.1 ADP-dependent glucokinase isoform X3