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    Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 [ Mus musculus (house mouse) ]

    Gene ID: 631304, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Cyp4f40provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 40provided by MGI
    Primary source
    MGI:MGI:3645508
    See related
    Ensembl:ENSMUSG00000090700 AllianceGenome:MGI:3645508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG631304
    Summary
    Predicted to enable fatty acid binding activity and monooxygenase activity. Predicted to be involved in icosanoid metabolic process and quinone catabolic process. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 63.3), colon adult (RPKM 23.3) and 2 other tissues See more
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    Genomic context

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    See Cyp4f40 in Genome Data Viewer
    Location:
    17 B1; 17 17.71 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32877860..32895893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32658886..32676919)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42390 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 37 Neighboring gene STARR-seq mESC enhancer starr_42391 Neighboring gene cytochrome P450, family 4, subfamily f, member 38, pseudogene Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 15 Neighboring gene predicted gene, 53996

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 4, subfamily f, polypeptide 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101588.2 → NP_001095058.1  cytochrome P450, family 4, subfamily f, polypeptide 40

      See identical proteins and their annotated locations for NP_001095058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      CT033759
      Consensus CDS
      CCDS50060.1
      UniProtKB/TrEMBL
      B2RY43, G3UW81
      Related
      ENSMUSP00000129536.2, ENSMUST00000165061.2
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 515
      p450; Cytochrome P450

    2. NM_001368735.1 → NP_001355664.1  cytochrome P450, family 4, subfamily f, polypeptide 40

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      CT033759
      Consensus CDS
      CCDS50060.1
      UniProtKB/TrEMBL
      B2RY43, G3UW81
      Related
      ENSMUSP00000157311.2, ENSMUST00000235086.2
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 515
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32877860..32895893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524759.1 → XP_006524822.1  cytochrome P450, family 4, subfamily f, polypeptide 40 isoform X2

      See identical proteins and their annotated locations for XP_006524822.1

      UniProtKB/TrEMBL
      B2RY43, G3UW81
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 515
      p450; Cytochrome P450

    2. XM_006524757.2 → XP_006524820.1  cytochrome P450, family 4, subfamily f, polypeptide 40 isoform X1

      UniProtKB/TrEMBL
      B2RY43
      Conserved Domains (1) summary
      pfam00067
      Location:79 → 542
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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