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    Pusl1 pseudouridylate synthase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 433813, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Pusl1provided by MGI
    Official Full Name
    pseudouridylate synthase-like 1provided by MGI
    Primary source
    MGI:MGI:3047787
    See related
    Ensembl:ENSMUSG00000051557 AllianceGenome:MGI:3047787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810021I11Rik
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Predicted to act upstream of or within tRNA processing. Predicted to be located in mitochondrion. Orthologous to human PUSL1 (pseudouridine synthase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 20.1), adrenal adult (RPKM 18.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 87.66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155973314..155976231, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155888857..155891858, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Busch JD, et al. Cell Rep, 2019 Nov 5. PMID 31693908, Free PMC Article
    2. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Max M, et al. Nat Genet, 2001 May. PMID 11326277
    3. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Li X, et al. Mamm Genome, 2001 Jan. PMID 11178737, Free PMC Article
    4. A candidate taste receptor gene near a sweet taste locus. Montmayeur JP, et al. Nat Neurosci, 2001 May. PMID 11319557
    5. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
      Title: MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA pseudouridine synthase-like 1
    Names
    tRNA pseudouridylate synthase-like 1
    tRNA-uridine isomerase-like 1
    NP_001028662.1
    XP_030109505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033490.1 → NP_001028662.1  tRNA pseudouridine synthase-like 1

      See identical proteins and their annotated locations for NP_001028662.1

      Status: VALIDATED

      Source sequence(s)
      AL670236
      Consensus CDS
      CCDS51404.1
      UniProtKB/Swiss-Prot
      A2ADA5, Q3TVB3, Q3UAA3
      Related
      ENSMUSP00000095344.5, ENSMUST00000097737.5
      Conserved Domains (2) summary
      cd02570
      Location:18 → 284
      PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA
      PRK00021
      Location:13 → 284
      truA; tRNA pseudouridine synthase A; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155973314..155976231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253645.2 → XP_030109505.1  tRNA pseudouridine synthase-like 1 isoform X1

      Conserved Domains (1) summary
      cd02570
      Location:10 → 249
      PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA

    RNA

    1. XR_390764.4 RNA Sequence

    2. XR_001784162.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ADA5.1 GenPept UniProtKB/Swiss-Prot:A2ADA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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