Gnat3 G protein subunit alpha transducin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnat3provided by MGI
Official Full Name: G protein subunit alpha transducin 3provided by MGI
Primary source: MGI:MGI:3588268
See related: Ensembl:ENSMUSG00000028777 AllianceGenome:MGI:3588268
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtn; Hg1e; Ggust
Summary: Enables GTPase activity. Acts upstream of or within G protein-coupled receptor signaling pathway and sensory perception of taste. Located in cytoplasm. Part of heterotrimeric G-protein complex. Is expressed in alimentary system and liver. Orthologous to human GNAT3 (G protein subunit alpha transducin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 8.14 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (18167568..18224666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (17962570..18019668)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice.
Title: The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice.
Spleen lymphocytes with gustducin signaling may be involved in T-dependent immune response to the blood bacterial polysaccharides.
Title: Histotopography of α-Gustdusin- and T2R3-Expressing Lymphocytes in Mouse Spleen.
T1R3 and alpha-gustducin exhibited a stage-dependent expression pattern during mouse development, and a cell-specific pattern during the spermatogenic cycle.
Title: Expression patterns of taste receptor type 1 subunit 3 and α-gustducin in the mouse testis during development.
The role of alpha-gustducin in the development of obesity and adipocyte metabolism
Title: The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice.
speculate that TAS1R3 and GNAT3 activators may help infertile men, particularly those that are affected by some of the mentioned inhibitors and/or are diagnosed with idiopathic infertility involving signaling pathway of these receptors
Title: Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.
Data suggest that alpha-gustducin in colonic mucosa is a key signaling molecule coupling free fatty acid receptors (Gpr43, Gpr119, Gpr120) and possibly bile acid receptor (TGR5) to secretion of GLP-1 (glucagon-like peptide 1).
Title: Gustducin couples fatty acid receptors to GLP-1 release in colon.
This study provides the first evidence that alpha-gustducin is involved in the octanoylation of ghrelin.
Title: Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein.
Data suggest that proteins of the taste transduction cascade (alpha-gustducin, G-protein gamma13, and phospholipase Cbeta2) are expressed in testis and are in involved in spermatogenesis.
Title: Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice.
The evidence suggests that alpha-gustducin may selectively participate in signal transduction in the axon terminals of rod bipolar cells in the mammalian retina.
Title: Expression of α-gustducin in mammalian retinas.
investigated whether T2R-agonists affect (i) ghrelin release via alpha-gustducin and (ii) food intake and gastric emptying via the release of ghrelin
Title: Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gnat3 (e-PCR), detects polymorphism
- UniSTS:532431

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of umami taste	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(t) subunit alpha-3

Names: alpha-gustducin; guanine nucleotide binding protein, alpha transducing 3; gustducin alpha-3 chain; heterotrimeric guanine nucleotide-binding protein 1e

NP_001074612.1

EC 2.3.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081143.1 → NP_001074612.1 guanine nucleotide-binding protein G(t) subunit alpha-3

See identical proteins and their annotated locations for NP_001074612.1

Status: PROVISIONAL

Source sequence(s)

AC129572

Consensus CDS

CCDS39017.1

UniProtKB/Swiss-Prot

Q3V3I2

UniProtKB/TrEMBL

B2RVZ3

Related

ENSMUSP00000030561.8, ENSMUST00000030561.9

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)