CD5L CD5 molecule like [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD5Lprovided by HGNC
Official Full Name: CD5 molecule likeprovided by HGNC
Primary source: HGNC:HGNC:1690
See related: Ensembl:ENSG00000073754 MIM:602592; AllianceGenome:HGNC:1690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward spleen (RPKM 260.3) See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (157827068..157841808, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (156964145..156978876, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (157796858..157811598, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
Title: AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
Title: Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
Title: The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
[CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
Title: [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
Title: Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
Title: CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
Title: Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
The Role of Renal Macrophage, AIM, and TGF-beta1 Expression in Renal Fibrosis Progression in IgAN Patients.
Title: The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients.
Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
Title: Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
The present study is the first to document that CD5L release occurs in methicillin-resistant S. aureus (MRSA) pneumonia. It is interesting that treatment with antibody against CD5L can protect against MRSA, which was associated with an improvement of bacterial clearance and a reduction of inflammatory response.
Title: CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
nucleocapsid	gag	HIV-1 NC upregulates CD5 molecule-like in HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3339 (e-PCR)
- UniSTS:22555

D1S3558 (e-PCR)
- UniSTS:81465

SHGC-58141 (e-PCR)
- UniSTS:14959

RH12832 (e-PCR)
- UniSTS:57724

D1S176 (e-PCR)
- UniSTS:146596

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in regulation of complement activation	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in blood microparticle	HDA more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CD5 antigen-like

Names: CD5 antigen-like (scavenger receptor cysteine rich family); apoptosis inhibitor 6; apoptosis inhibitor expressed by macrophages; apoptosis inhibitor of macrophage; igM-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347698.2 → NP_001334627.1 CD5 antigen-like isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus compard to isoform 1.

Source sequence(s)

AL139409, AY358494, DA957550

UniProtKB/Swiss-Prot

O43866
NM_005894.3 → NP_005885.1 CD5 antigen-like isoform 1 precursor

See identical proteins and their annotated locations for NP_005885.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1, which differs only in the last aa compared to isoform 2.

Source sequence(s)

AK292040, AL139409, DA957550, U82812

Consensus CDS

CCDS1171.1

UniProtKB/Swiss-Prot

A8K7M5, O43866, Q6UX63

Related

ENSP00000357156.4, ENST00000368174.5

Conserved Domains (1) summary

smart00202
Location:244 → 346

SR; Scavenger receptor Cys-rich