Larsen syndrome
- Synonyms
- Bilateral dislocation of the knees, pes cavus, cylindrically shaped fingers and characteristic facies; Larsen syndrome, dominant type
- Modes of inheritance
- Autosomal dominant inheritance (Orphanet)
Summary
Excerpted from the GeneReview:- Full text of GeneReview (by section):
- Summary
- GeneReview Scope
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Stephen Robertson
- view full author information
Available tests
Check Related conditions for additional relevant tests.
Clinical features
Help- Abnormality of head or neck
- Cleft palate
Cleft palate
- MedGen UID: 756015
- Concept ID: C2981150
- Finding: Congenital Abnormality
Abnormality of head or neck
- Cleft upper lip
Cleft upper lip
- MedGen UID: 40327
- Concept ID: C0008924
- Finding: Congenital Abnormality
Abnormality of head or neck
- Depressed nasal bridge
Depressed nasal bridge
- MedGen UID: 373112
- Concept ID: C1836542
- Finding: Finding
Abnormality of head or neck
- Flat face
Flat face
- MedGen UID: 342829
- Concept ID: C1853241
- Finding: Finding
Abnormality of head or neck
- Midface retrusion
Midface retrusion
- MedGen UID: 339938
- Concept ID: C1853242
- Finding: Anatomical Abnormality
Abnormality of head or neck
- Partial congenital absence of teeth
Partial congenital absence of teeth
- MedGen UID: 43794
- Concept ID: C0020608
- Finding: Congenital Abnormality
Abnormality of head or neck
- Prominent forehead
Prominent forehead
- MedGen UID: 373291
- Concept ID: C1837260
- Finding: Finding
Abnormality of head or neck
- Cleft palate
- Abnormality of limbs
- Accessory carpal bones
Accessory carpal bones
- MedGen UID: 120549
- Concept ID: C0265609
- Finding: Congenital Abnormality
Abnormality of limbs
- Bipartite calcaneus
Bipartite calcaneus
- MedGen UID: 320639
- Concept ID: C1835574
- Finding: Finding
Abnormality of limbs
- Clubfoot
Clubfoot
- MedGen UID: 3130
- Concept ID: C0009081
- Finding: Congenital Abnormality
Abnormality of limbs
- Knee dislocation
Knee dislocation
- MedGen UID: 102364
- Concept ID: C0159970
- Finding: Injury or Poisoning
Abnormality of limbs
- Multiple carpal ossification centers
Multiple carpal ossification centers
- MedGen UID: 320638
- Concept ID: C1835573
- Finding: Finding
Abnormality of limbs
- Short metacarpal
Short metacarpal
- MedGen UID: 323064
- Concept ID: C1837084
- Finding: Anatomical Abnormality
Abnormality of limbs
- Short metatarsal
Short metatarsal
- MedGen UID: 341358
- Concept ID: C1849020
- Finding: Finding
Abnormality of limbs
- Spatulate thumbs
Spatulate thumbs
- MedGen UID: 66028
- Concept ID: C0241395
- Finding: Finding
Abnormality of limbs
- Talipes equinovalgus
Talipes equinovalgus
- MedGen UID: 78567
- Concept ID: C0265642
- Finding: Congenital Abnormality
Abnormality of limbs
- Tapered humerus
Tapered humerus
- MedGen UID: 871066
- Concept ID: C4025531
- Finding: Anatomical Abnormality
Abnormality of limbs
- Accessory carpal bones
- Abnormality of the cardiovascular system
- Aortic aneurysm
Aortic aneurysm
- MedGen UID: 362
- Concept ID: C0003486
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Atrial septal defect
Atrial septal defect
- MedGen UID: 6753
- Concept ID: C0018817
- Finding: Congenital Abnormality
Abnormality of the cardiovascular system
- Ventricular septal defect
Ventricular septal defect
- MedGen UID: 42366
- Concept ID: C0018818
- Finding: Congenital Abnormality
Abnormality of the cardiovascular system
- Aortic aneurysm
- Abnormality of the eye
- Corneal opacity
Corneal opacity
- MedGen UID: 40485
- Concept ID: C0010038
- Finding: Finding
Abnormality of the eye
- Hypertelorism
Hypertelorism
- MedGen UID: 9373
- Concept ID: C0020534
- Finding: Finding
Abnormality of the eye
- Corneal opacity
- Abnormality of the genitourinary system
- Cryptorchidism
Cryptorchidism
- MedGen UID: 8192
- Concept ID: C0010417
- Finding: Congenital Abnormality
Abnormality of the genitourinary system
- Cryptorchidism
- Abnormality of the integument
- Short nail
Short nail
- MedGen UID: 140850
- Concept ID: C0423808
- Finding: Finding
Abnormality of the integument
- Short nail
- Abnormality of the musculoskeletal system
- Beaking of vertebral bodies
Beaking of vertebral bodies
- MedGen UID: 341588
- Concept ID: C1856599
- Finding: Finding
Abnormality of the musculoskeletal system
- Cervical kyphosis
Cervical kyphosis
- MedGen UID: 107898
- Concept ID: C0575170
- Finding: Finding
Abnormality of the musculoskeletal system
- Dislocated wrist
Dislocated wrist
- MedGen UID: 480063
- Concept ID: C3278433
- Finding: Injury or Poisoning
Abnormality of the musculoskeletal system
- Elbow dislocation
Elbow dislocation
- MedGen UID: 404765
- Concept ID: C2720437
- Finding: Injury or Poisoning
Abnormality of the musculoskeletal system
- Frontal bossing
Frontal bossing
- MedGen UID: 67453
- Concept ID: C0221354
- Finding: Congenital Abnormality
Abnormality of the musculoskeletal system
- Hip dislocation
Hip dislocation
- MedGen UID: 42455
- Concept ID: C0019554
- Finding: Injury or Poisoning
Abnormality of the musculoskeletal system
- Hypoplastic cervical vertebrae
Hypoplastic cervical vertebrae
- MedGen UID: 372079
- Concept ID: C1835570
- Finding: Finding
Abnormality of the musculoskeletal system
- Joint hypermobility
Joint hypermobility
- MedGen UID: 336793
- Concept ID: C1844820
- Finding: Finding
Abnormality of the musculoskeletal system
- Malar flattening
Malar flattening
- MedGen UID: 347616
- Concept ID: C1858085
- Finding: Finding
Abnormality of the musculoskeletal system
- Pectus carinatum
Pectus carinatum
- MedGen UID: 57643
- Concept ID: C0158731
- Finding: Finding
Abnormality of the musculoskeletal system
- Pectus excavatum
Pectus excavatum
- MedGen UID: 781174
- Concept ID: C2051831
- Finding: Finding
Abnormality of the musculoskeletal system
- Scoliosis
Scoliosis
- MedGen UID: 11348
- Concept ID: C0036439
- Finding: Disease or Syndrome
Abnormality of the musculoskeletal system
- Shallow orbits
Shallow orbits
- MedGen UID: 351328
- Concept ID: C1865244
- Finding: Finding
Abnormality of the musculoskeletal system
- Spondylolysis
Spondylolysis
- MedGen UID: 21294
- Concept ID: C0038018
- Finding: Disease or Syndrome
Abnormality of the musculoskeletal system
- Vertebral fusion
Vertebral fusion
- MedGen UID: 480139
- Concept ID: C3278509
- Finding: Anatomical Abnormality
Abnormality of the musculoskeletal system
- Beaking of vertebral bodies
- Abnormality of the nervous system
- Intellectual disability
Intellectual disability
- MedGen UID: 811461
- Concept ID: C3714756
- Finding: Mental or Behavioral Dysfunction
Abnormality of the nervous system
- Spina bifida occulta
Spina bifida occulta
- MedGen UID: 36380
- Concept ID: C0080174
- Finding: Congenital Abnormality
Abnormality of the nervous system
- Spinal cord compression
Spinal cord compression
- MedGen UID: 11549
- Concept ID: C0037926
- Finding: Disease or Syndrome
Abnormality of the nervous system
- Intellectual disability
- Abnormality of the respiratory system
- Bronchomalacia
Bronchomalacia
- MedGen UID: 82679
- Concept ID: C0264353
- Finding: Disease or Syndrome
Abnormality of the respiratory system
- Tracheal stenosis
Tracheal stenosis
- MedGen UID: 21227
- Concept ID: C0040583
- Finding: Disease or Syndrome
Abnormality of the respiratory system
- Tracheomalacia
Tracheomalacia
- MedGen UID: 215296
- Concept ID: C0948187
- Finding: Disease or Syndrome
Abnormality of the respiratory system
- Bronchomalacia
- Ear malformation
- Conductive hearing impairment
Conductive hearing impairment
- MedGen UID: 9163
- Concept ID: C0018777
- Finding: Disease or Syndrome
Ear malformation
- Hearing impairment
Hearing impairment
- MedGen UID: 235586
- Concept ID: C1384666
- Finding: Disease or Syndrome
Ear malformation
- Conductive hearing impairment
- Growth abnormality
- Fetal growth restriction
Fetal growth restriction
- MedGen UID: 4693
- Concept ID: C0015934
- Finding: Pathologic Function
Growth abnormality
- Short stature
Short stature
- MedGen UID: 87607
- Concept ID: C0349588
- Finding: Finding
Growth abnormality
- Fetal growth restriction
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