Mesangiocapillary glomerulonephritis, type II
- Synonyms
- Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II; Dense deposit disease; MPGN 2; Membranoproliferative glomerulonephritis type 2; Mesangiocapillary glomerulonephritis type 2
- Modes of inheritance
- Autosomal recessive inheritance (Orphanet)
Summary
Excerpted from the GeneReview:C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid phase (as opposed to cell surface) that is rarely inherited in a simple mendelian fashion. C3G affects individuals of all ages, with a median age at diagnosis of 23 years. Individuals with C3G typically present with hematuria, proteinuria, hematuria and proteinuria, acute nephritic syndrome or nephrotic syndrome, and low levels of the complement component C3. Spontaneous remission of C3G is uncommon, and about half of affected individuals develop end-stage renal disease (ESRD) within ten years of diagnosis, occasionally developing the late comorbidity of impaired visual acuity.
- Full text of GeneReview (by section):
- Summary
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- References
- Chapter Notes
- Authors:
- Bertha MartÃn
- Richard JH Smith
- view full author information
Available tests
3 tests are in the database for this condition.
Check Related conditions for additional relevant tests.
Clinical tests (3 available)
Molecular Genetics Tests
Genes See tests for all associated and related genes
Also known as: AHUS7, DAGK5, DAGK6, DGK, NPHS7, DGKE
Summary: diacylglycerol kinase epsilon
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