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GTR Home > Conditions/Phenotypes > Autosomal dominant Parkinson disease 8

Autosomal dominant Parkinson disease 8

Synonyms
LRRK2-Related Parkinson Disease; Parkinson disease 8; Parkinson disease 8, susceptibility to

Summary

LRRK2 Parkinson disease (PD) is characterized by features consistent with idiopathic PD: initial motor features of slowly progressive asymmetric tremor at rest and/or bradykinesia, cogwheel muscle rigidity, postural instability, and gait abnormalities that may include festination and freezing. Certain nonmotor symptoms in LRRK2-PD, especially REM sleep behavior disorder and cognitive decline, may occur at similar or slightly reduced frequency compared to typical idiopathic* PD. Onset is generally after age 50, although early-onset (in the 20s) and late-onset (in the 90s) disease has been described. * Idiopathic PD refers to the presence of signs and symptoms of PD for which the etiology is currently unknown and in which there is no known family history of PD. [from GeneReviews]

Available tests

35 tests are in the database for this condition.

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Clinical tests (35 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: AURA17, DARDARIN, PARK8, RIPK7, ROCO2, LRRK2
    Summary: leucine rich repeat kinase 2

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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