U.S. flag

An official website of the United States government

GTR Home > Conditions/Phenotypes > Cenani-Lenz syndactyly syndrome

Cenani-Lenz syndactyly syndrome

Synonyms
Cenani syndactylism; SYNDACTYLY, TYPE VII; Syndactyly Cenani Lenz type; Syndactyly type 7
Modes of inheritance
Autosomal recessive inheritance (Orphanet)

Summary

Cenani-Lenz syndactyly syndrome (CLSS) is an autosomal recessive disorder characterized mainly by anomalies of distal limb development, with fusion and disorganization of metacarpal and phalangeal bones, radius and ulnar shortening, radioulnar synostosis, and severe syndactyly of hands and feet. Mild facial dysmorphism is present in most patients. Kidney anomalies, including renal agenesis and hypoplasia, occur in over half of patients (summary by Li et al., 2010). [from OMIM]

Available tests

25 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (25 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2, LRP4
    Summary: LDL receptor related protein 4

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

Show allHide all

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.