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GTR Home > Conditions/Phenotypes > Multiple sclerosis, susceptibility to

Multiple sclerosis, susceptibility to

Synonyms
DISSEMINATED SCLEROSIS; Multiple sclerosis susceptibility

Summary

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS) with various degrees of axonal damage. MS affects mainly young adults with predominance for females. The disorder often leads to substantial disability (summary by Bomprezzi et al., 2003). Genetic Heterogeneity of Susceptibility to Multiple Sclerosis Additional MS susceptibility loci include MS2 (612594) on chromosome 10p15, MS3 (612595) on chromosome 5p13, MS4 (612596) on chromosome 1p36, and MS5 (614810), conferred by variation in the TNFRSF1A gene (191190) on chromosome 12p13. [from OMIM]

Available tests

7 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (7 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: CELIAC1, HLA-DQB, IDDM1, HLA-DQB1
    Summary: major histocompatibility complex, class II, DQ beta 1

  • Also known as: DRB1, HLA-DR1B, HLA-DRB, SS1, HLA-DRB1
    Summary: major histocompatibility complex, class II, DR beta 1

  • Also known as: CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, PDCD1
    Summary: programmed cell death 1

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

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