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GTR Home > Conditions/Phenotypes > Nasopharyngeal carcinoma

Nasopharyngeal carcinoma

Synonyms
Nasopharyngeal carcinoma, somatic
Modes of inheritance
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)

Summary

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated (Tse et al., 2009). Genetic Heterogeneity of Susceptibility to Nasopharyngeal Carcinoma NPCA1 maps to chromosome 4p. NPCA2 (161550) maps to chromosome 6p21. NPCA3 (617075) is associated with variation in the MST1R gene (600168) on chromosome 3p21. Somatic mutations have been found in the TP53 gene (191170) in nasopharyngeal carcinoma tumors. [from OMIM]

Available tests

68 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (68 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: BCC7, BMFS5, LFS1, P53, TRP53, TP53
    Summary: tumor protein p53

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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Reviews

Clinical resources

Practice guidelines

  • NCCN, 2024
    NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Molecular resources

Consumer resources

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