Efavirenz response

Synonyms: Efavirenz central nervous system toxicity, susceptibility to; Efavirenz, poor metabolism of

Summary

Efavirenz is a non-nucleoside reverse transcriptase inhibitor widely used worldwide to treat HIV-1 infection. It is predominantly metabolized into inactive metabolites by cytochrome P450-2B6 (CYP2B6). Genetic variants in CYP2B6 (e.g. CYP2B6*6 and *18), along with other genetic and non-genetic factors, are known to influence variability in efavirenz response. Patients with certain CYP2B6 genetic polymorphisms may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. [from PharmGKB]

Available tests

21 tests are in the database for this condition.

Clinical tests (21 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

Associated genes Help
Genes reported to contribute to the condition.

CYP2B6
47 tests
Also known as: CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, CYP2B6
Summary: cytochrome P450 family 2 subfamily B member 6

Reviews

Clinical resources

Practice guidelines

PAGAA, 2024
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services.
DailyMed Drug Label, 2020
DailyMed Drug Label, SUSTIVA- efavirenz, 2020

Molecular resources

Consumer resources

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