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GTR Home > Conditions/Phenotypes > Spermatogenic failure 61

Spermatogenic failure 61

Summary

Spermatogenic failure-61 (SPGF61) is characterized by male infertility due to nonobstructive azoospermia, resulting from complete meiotic arrest at the primary spermatocyte stage (Riera-Escamilla et al., 2019;van der Bijl et al., 2019). Mutation in the STAG3 gene also causes premature ovarian failure (POF8; 615723), resulting in female infertility. For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: SA3, SPGF61, STAG3
    Summary: STAG3 cohesin complex component

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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