Multicentric osteolysis, nodulosis, and arthropathy
- Synonyms
- AL-AQEEL SEWAIRI SYNDROME; NAO SYNDROME; NOA syndrome; Nodulosis arthropathy osteolysis syndrome; Osteolysis, hereditary multicentric; Torg syndrome; Torg-Winchester syndrome
Summary
Excerpted from the GeneReview:Multicentric osteolysis nodulosis and arthropathy (MONA) is a skeletal dysplasia characterized by progressive osteolysis (particularly of the carpal and tarsal bones), osteoporosis, subcutaneous nodules on the palms and soles, and progressive arthropathy (joint contractures, pain, swelling, and stiffness). Other manifestations include coarse facies, pigmented skin lesions, cardiac defects, and corneal opacities. Onset is usually between ages six months and six years (range: birth to 11 years).
- Full text of GeneReview (by section):
- Summary
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Gandham SriLakshmi Bhavani
- Hitesh Shah
- Anju Shukla
- view full author information
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