NRAS NRAS proto-oncogene, GTPase
Gene ID: 4893, updated on 12-Sep-2024Gene type: protein coding
Also known as: NS6; CMNS; KRAS; NCMS; ALPS4; N-ras; NRAS1
- See all available tests in GTR for this gene
- Go to complete Gene record for NRAS
- Go to Variation Viewer for NRAS variants
Summary
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Autoimmune lymphoproliferative syndrome type 4 | See labs |
| Cetuximab response MedGen: CN077967GeneReviews: Not available | See labs |
| Colorectal cancer | See labs |
| Common genetic variants on 1p13.2 associate with risk of autism. GeneReviews: Not available | |
| Epidermal nevus | See labs |
| Large congenital melanocytic nevus | See labs |
| Linear nevus sebaceous syndrome | See labs |
| Neurocutaneous melanocytosis | See labs |
| Noonan syndrome 6 | See labs |
| Panitumumab response MedGen: CN077999GeneReviews: Not available | See labs |
| Thyroid cancer, nonmedullary, 2 | See labs |
Genomic context
- Location:
- 1p13.2
- Sequence:
- Chromosome: 1; NC_000001.11 (114704469..114716771, complement)
- Total number of exons:
- 7
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for NRAS variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- Catalogue of Somatic Mutations in Cancer (COSMIC)
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- NRAS database
- NRASbase: Mutation registry for Autoimmune lymphoproliferative syndrome type IV
- NSEuroNet database - NRAS
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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