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Orbital granuloma

MedGen UID:
102330
•Concept ID:
C0155262
•
Disease or Syndrome
Synonyms: Orbital Granuloma; orbital granuloma
SNOMED CT: Orbital granuloma (72776003)
 
Monarch Initiative: MONDO:0001048

Definition

A granuloma located on the orbit of the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbital granuloma

Professional guidelines

PubMed

Adult Xanthogranulomatous Disease of the Orbit: Clinical Presentations, Evaluation, and Management.
Ortiz Salvador JM, Subiabre Ferrer D, Pérez Ferriols A
Actas Dermosifiliogr 2017 Jun;108(5):400-406. Epub 2017 Mar 3 doi: 10.1016/j.ad.2016.12.005. PMID: 28262109
Adult orbital xanthogranulomas: clinical features and management.
Kiratli H, Kiliç M, Tarlan B, Söylemezoglu F
Eur J Ophthalmol 2015 Jul-Aug;25(4):288-92. Epub 2015 Jan 15 doi: 10.5301/ejo.5000555. PMID: 25612656
Immunomodulatory drugs for the treatment of periorbital necrobiotic xanthogranuloma.
Abdul-Hay M
Clin Adv Hematol Oncol 2013 Oct;11(10):680-1. PMID: 24518383

Recent clinical studies

Etiology

Sarcoidosis in the national veteran population: association of ocular inflammation and mortality.
Birnbaum AD, French DD, Mirsaeidi M, Wehrli S
Ophthalmology 2015 May;122(5):934-8. Epub 2015 Feb 14 doi: 10.1016/j.ophtha.2015.01.003. PMID: 25687027Free PMC Article
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases.
Bitik B, Kılıç L, Küçükşahin O, Şahin K, Tufan A, Karadağ Ö, Pay S, Ateş A, Ucar M, Tutar H, Karaaslan Y, Yilmaz S, Ertenli AI, Konuk O, Turgay M, Goker B
Rheumatol Int 2015 Jun;35(6):1083-92. Epub 2014 Nov 21 doi: 10.1007/s00296-014-3179-8. PMID: 25413843
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations.
Holle JU, Dubrau C, Herlyn K, Heller M, Ambrosch P, Noelle B, Reinhold-Keller E, Gross WL
Ann Rheum Dis 2012 Mar;71(3):327-33. Epub 2011 Oct 21 doi: 10.1136/ard.2011.153601. PMID: 22021864
Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis.
Yalçindağ FN, Amer R, Forrester JV
J Ocul Pharmacol Ther 2008 Apr;24(2):249-54. doi: 10.1089/jop.2007.0055. PMID: 18321200
Indirect immunofluorescence study of the cornea and the conjunctiva in a xenogeneic system: analysis of humoral reactivity in patients with Wegener's granulomatosis.
Przyklang U, Nölle B, Reinhold-Keller E, Duncker G
Graefes Arch Clin Exp Ophthalmol 1996 Feb;234(2):79-86. doi: 10.1007/BF00695245. PMID: 8720676

Diagnosis

Updates of ocular involvement in granulomatosis with polyangiitis.
Mei L, Wang L, Yan H
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1515-1523. Epub 2022 Dec 7 doi: 10.1007/s00417-022-05918-w. PMID: 36473987
Wegener's granulomatosis with orbital involvement: case report and literature review.
Andrada-Elena M, Ioana TT, Mihaela FM, Irina-Elena C, Andrei TI, Florian B
Rom J Ophthalmol 2021 Jan-Mar;65(1):93-97. doi: 10.22336/rjo.2021.19. PMID: 33817443Free PMC Article
Sarcoidosis in the national veteran population: association of ocular inflammation and mortality.
Birnbaum AD, French DD, Mirsaeidi M, Wehrli S
Ophthalmology 2015 May;122(5):934-8. Epub 2015 Feb 14 doi: 10.1016/j.ophtha.2015.01.003. PMID: 25687027Free PMC Article
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases.
Bitik B, Kılıç L, Küçükşahin O, Şahin K, Tufan A, Karadağ Ö, Pay S, Ateş A, Ucar M, Tutar H, Karaaslan Y, Yilmaz S, Ertenli AI, Konuk O, Turgay M, Goker B
Rheumatol Int 2015 Jun;35(6):1083-92. Epub 2014 Nov 21 doi: 10.1007/s00296-014-3179-8. PMID: 25413843
Orbital granuloma annulare as presentation of systemic sarcoidosis.
Kang JJ, Aakalu VK, Lin A, Setabutr P
Orbit 2013 Dec;32(6):372-4. Epub 2013 Jul 29 doi: 10.3109/01676830.2013.812125. PMID: 23895369Free PMC Article

Therapy

Orbital granuloma formation following autoinjection of paraffin oil: management considerations.
Cadmus SD, Thelin LL, Vrcek I
Cutis 2020 Oct;106(4):E23-E26. doi: 10.12788/cutis.0117. PMID: 33186437
Orbital granuloma: a rare manifestation of extrapulmonary tuberculosis.
Benech N, Jouanneau E, Chidiac C, Ferry T
BMJ Case Rep 2016 Mar 1;2016 doi: 10.1136/bcr-2016-214542. PMID: 26933187Free PMC Article
Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases.
Bitik B, Kılıç L, Küçükşahin O, Şahin K, Tufan A, Karadağ Ö, Pay S, Ateş A, Ucar M, Tutar H, Karaaslan Y, Yilmaz S, Ertenli AI, Konuk O, Turgay M, Goker B
Rheumatol Int 2015 Jun;35(6):1083-92. Epub 2014 Nov 21 doi: 10.1007/s00296-014-3179-8. PMID: 25413843
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations.
Holle JU, Dubrau C, Herlyn K, Heller M, Ambrosch P, Noelle B, Reinhold-Keller E, Gross WL
Ann Rheum Dis 2012 Mar;71(3):327-33. Epub 2011 Oct 21 doi: 10.1136/ard.2011.153601. PMID: 22021864
Occlusion of the retinal artery in two cases of orbital granuloma.
Godfrey RC
Br J Ophthalmol 1969 Oct;53(10):703-6. doi: 10.1136/bjo.53.10.703. PMID: 5347174Free PMC Article

Prognosis

Updates of ocular involvement in granulomatosis with polyangiitis.
Mei L, Wang L, Yan H
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1515-1523. Epub 2022 Dec 7 doi: 10.1007/s00417-022-05918-w. PMID: 36473987
Sarcoidosis in the national veteran population: association of ocular inflammation and mortality.
Birnbaum AD, French DD, Mirsaeidi M, Wehrli S
Ophthalmology 2015 May;122(5):934-8. Epub 2015 Feb 14 doi: 10.1016/j.ophtha.2015.01.003. PMID: 25687027Free PMC Article
Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis.
Yalçindağ FN, Amer R, Forrester JV
J Ocul Pharmacol Ther 2008 Apr;24(2):249-54. doi: 10.1089/jop.2007.0055. PMID: 18321200

Clinical prediction guides

Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases.
Bitik B, Kılıç L, Küçükşahin O, Şahin K, Tufan A, Karadağ Ö, Pay S, Ateş A, Ucar M, Tutar H, Karaaslan Y, Yilmaz S, Ertenli AI, Konuk O, Turgay M, Goker B
Rheumatol Int 2015 Jun;35(6):1083-92. Epub 2014 Nov 21 doi: 10.1007/s00296-014-3179-8. PMID: 25413843
Orbital granuloma annulare as presentation of systemic sarcoidosis.
Kang JJ, Aakalu VK, Lin A, Setabutr P
Orbit 2013 Dec;32(6):372-4. Epub 2013 Jul 29 doi: 10.3109/01676830.2013.812125. PMID: 23895369Free PMC Article
Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations.
Holle JU, Dubrau C, Herlyn K, Heller M, Ambrosch P, Noelle B, Reinhold-Keller E, Gross WL
Ann Rheum Dis 2012 Mar;71(3):327-33. Epub 2011 Oct 21 doi: 10.1136/ard.2011.153601. PMID: 22021864
A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease.
Tsukamoto H, Nagafuji K, Horiuchi T, Miyamoto T, Aoki K, Takase K, Henzan H, Himeji D, Koyama T, Miyake K, Inoue Y, Nakashima H, Otsuka T, Tanaka Y, Nagasawa K, Harada M
Ann Rheum Dis 2006 Apr;65(4):508-14. Epub 2005 Aug 26 doi: 10.1136/ard.2005.037879. PMID: 16126798Free PMC Article
Mycobacterium chelonei and orbital granuloma after tear duct probing.
Smith RE, Salz JJ, Moors R, Silverstein D, Lewis W
Am J Ophthalmol 1980 Jan;89(1):139-41. doi: 10.1016/0002-9394(80)90241-x. PMID: 7356779

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