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Giant cell reparative granuloma

MedGen UID:
102385
•Concept ID:
C0162375
•
Disease or Syndrome
Synonym: Granuloma, Giant Cell Reparative
SNOMED CT: Central giant cell granuloma (15350006); CGCG - Central giant cell granuloma (15350006); Central giant cell reparative granuloma of jaw (15350006)
 
Monarch Initiative: MONDO:0006770

Definition

A localized, benign but sometimes aggressive osteolytic lesion of the jaws characterized by osteoclast-type giant cells in a vascular stroma. It more frequently affects the anterior jaws, in particular the mandible. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell reparative granuloma

Professional guidelines

PubMed

Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management.
Koraitim M, Medra AM, Salloum AM, Shehata EA
J Craniofac Surg 2022 May 1;33(3):e265-e267. Epub 2021 Aug 13 doi: 10.1097/SCS.0000000000008085. PMID: 34387270
Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray.
Allon DM, Anavi Y, Calderon S
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Jun;107(6):811-8. doi: 10.1016/j.tripleo.2009.02.013. PMID: 19464656
Giant cell myocarditis: diagnosis and treatment.
Cooper LT Jr
Herz 2000 May;25(3):291-8. doi: 10.1007/s000590050023. PMID: 10904855

Recent clinical studies

Etiology

Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the Head: CT and MR Imaging Findings.
Li SL, Kong YG, Zou Y, Yu X, Ouyang HQ, Chen SM, Deng YQ
Comb Chem High Throughput Screen 2023;26(6):1180-1185. doi: 10.2174/1386207325666220818124912. PMID: 35984022
Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.
Kadlub N, Sessiecq Q, Dainese L, Joly A, Lehalle D, Marlin S, Badoual C, Galmiche L, Majoufre-Lefebvre C, Berdal A, Deckert M, Vazquez MP, Descroix V, Coudert AE, Picard A
Hum Pathol 2016 Dec;58:62-71. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.019. PMID: 27498064
Orbital manifestations of Noonan syndrome.
Randolph JC, Sokol JA, Lee HB, Nunery WR
Ophthalmic Plast Reconstr Surg 2011 Nov-Dec;27(6):e160-3. doi: 10.1097/IOP.0b013e318209976c. PMID: 21464791
Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma.
Ilaslan H, Sundaram M, Unni KK
AJR Am J Roentgenol 2003 Jun;180(6):1681-7. doi: 10.2214/ajr.180.6.1801681. PMID: 12760943
Cherubism: clinicopathologic features.
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884

Diagnosis

Giant cell reparative granuloma of the phalanx in a violinist.
Ventura-Parellada C, Martínez-Ruiz A, Subirà-I-Álvarez T
Occup Med (Lond) 2021 Aug 20;71(4-5):231-233. doi: 10.1093/occmed/kqab069. PMID: 34105725
Cervical-Thoracic Epidural Giant Cell Reparative Granuloma: Case Report and Review of the Literature.
Hu X, Yuan T, Lou L, Wang Y, Liu Y, Quan G
World Neurosurg 2020 Apr;136:66-69. Epub 2020 Jan 10 doi: 10.1016/j.wneu.2020.01.015. PMID: 31931251
Selected Giant Cell Rich Lesions of the Temporal Bone.
Martinez AP, Torres-Mora J
Head Neck Pathol 2018 Sep;12(3):367-377. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0906-6. PMID: 30069841Free PMC Article
Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.
Kadlub N, Sessiecq Q, Dainese L, Joly A, Lehalle D, Marlin S, Badoual C, Galmiche L, Majoufre-Lefebvre C, Berdal A, Deckert M, Vazquez MP, Descroix V, Coudert AE, Picard A
Hum Pathol 2016 Dec;58:62-71. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.019. PMID: 27498064
Giant-cell reparative granuloma.
Palacios E, Valvassori G
Ear Nose Throat J 2000 Sep;79(9):688. PMID: 11011486

Therapy

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review.
Weng JC, Li D, Wang L, Wu Z, Wang JM, Li GL, Jia W, Zhang LW, Zhang JT
J Neurosurg 2018 Oct 12;131(3):695-705. doi: 10.3171/2018.4.JNS1849. PMID: 30497189
Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine.
Akeda K, Kasai Y, Sakakibara T, Matsumine A, Takegami N, Yamada J, Sudo A
Spine (Phila Pa 1976) 2015 May 15;40(10):E601-8. doi: 10.1097/BRS.0000000000000862. PMID: 25955096
Prosthodontic treatment and medical considerations for a patient with Turner syndrome: a clinical report.
Nguyen CT, Hofstede TM
J Prosthodont 2012 Oct;21(7):552-5. Epub 2012 Jun 1 doi: 10.1111/j.1532-849X.2012.00868.x. PMID: 22672559
Giant cell reparative granuloma of the cranial vault-case report and review of literature.
Mukerji N, Willmott H, Joy A, Sutter R, Wadley J
Surg Neurol 2009 Apr;71(4):493-5. Epub 2008 Mar 4 doi: 10.1016/j.surneu.2007.09.042. PMID: 18291468
Giant cell reparative granuloma of the temporal bone treated with calcitonin.
Souter MA, Bird PA, Worthington JP
Otol Neurotol 2006 Oct;27(7):999-1002. doi: 10.1097/01.mao.0000224076.54978.f0. PMID: 16788413

Prognosis

Maxillary Giant Cell Granuloma: A Long-Term Follow-Up.
Arthur Md DM, Palacios E, Nguyen J
Ear Nose Throat J 2020 Jan;99(1):39-41. Epub 2019 Apr 23 doi: 10.1177/0145561319840867. PMID: 31012347
Maxillary Giant Cell Granuloma: A Long-Term Follow-Up.
McArthur D, Palacios E, Nguyen J
Ear Nose Throat J 2019 Jul;98(6):E70-E72. Epub 2019 May 7 doi: 10.1177/0145561319841238. PMID: 31064243
Giant cell reparative granuloma of the temporal bone: neuroradiological and immunohistochemical findings.
Yoshimura J, Onda K, Tanaka R, Takahashi H
Neurol Med Chir (Tokyo) 2002 Nov;42(11):510-5. doi: 10.2176/nmc.42.510. PMID: 12472217
Giant cell reparative granuloma of the small bones of the hands and feet: a report of three cases.
Forouhar FA, Phelan NP, Benton DC
Ann Clin Lab Sci 2000 Jul;30(3):272-7. PMID: 10945567
Cherubism: clinicopathologic features.
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884

Clinical prediction guides

Orbital Giant Cell Reparative Granuloma: A Case Report.
Wang N, Li J, Ma J
Ophthalmic Plast Reconstr Surg 2024 May-Jun 01;40(3):e97-e102. Epub 2024 May 10 doi: 10.1097/IOP.0000000000002622. PMID: 38738724Free PMC Article
Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the Head: CT and MR Imaging Findings.
Li SL, Kong YG, Zou Y, Yu X, Ouyang HQ, Chen SM, Deng YQ
Comb Chem High Throughput Screen 2023;26(6):1180-1185. doi: 10.2174/1386207325666220818124912. PMID: 35984022
Diffuse Tenosynovial Giant Cell Tumor Around the Temporomandibular Joint: An Entity With Special Radiologic and Pathologic Features.
Wang JG, Liu J, He B, Gao L, Zhang L, Liu J
J Oral Maxillofac Surg 2019 May;77(5):1022.e1-1022.e39. Epub 2019 Jan 29 doi: 10.1016/j.joms.2019.01.025. PMID: 30796908
Giant cell reparative granuloma of the scapula: report of a case and literature review.
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.
Kadlub N, Sessiecq Q, Dainese L, Joly A, Lehalle D, Marlin S, Badoual C, Galmiche L, Majoufre-Lefebvre C, Berdal A, Deckert M, Vazquez MP, Descroix V, Coudert AE, Picard A
Hum Pathol 2016 Dec;58:62-71. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.019. PMID: 27498064

Recent systematic reviews

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review.
Weng JC, Li D, Wang L, Wu Z, Wang JM, Li GL, Jia W, Zhang LW, Zhang JT
J Neurosurg 2018 Oct 12;131(3):695-705. doi: 10.3171/2018.4.JNS1849. PMID: 30497189

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