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Medullomyoblastoma with myogenic differentiation

MedGen UID:
104731
•Concept ID:
C0205833
•
Neoplastic Process
Synonyms: Medullomyoblastoma; Medullomyoblastomas
SNOMED CT: Medullomyoblastoma (24604009)
 
Monarch Initiative: MONDO:0006300

Definition

A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized by the morphologic features of a medulloblastoma and the presence of a striated muscle component. Its clinical behavior is similar to medulloblastoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedullomyoblastoma with myogenic differentiation

Professional guidelines

PubMed

EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Indian Society of Neuro-Oncology consensus guidelines for the contemporary management of medulloblastoma.
Gupta T, Sarkar C, Rajshekhar V, Chatterjee S, Shirsat N, Muzumdar D, Pungavkar S, Chinnaswamy G, Jalali R
Neurol India 2017 Mar-Apr;65(2):315-332. doi: 10.4103/0028-3886.201841. PMID: 28290395

Recent clinical studies

Etiology

Recent Advances in Pediatric Medulloblastoma.
Jackson K, Packer RJ
Curr Neurol Neurosci Rep 2023 Dec;23(12):841-848. Epub 2023 Nov 9 doi: 10.1007/s11910-023-01316-9. PMID: 37943476Free PMC Article
Pathology, diagnostics, and classification of medulloblastoma.
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska WA, Perek-Polnik M, Vasiljevic A, Faure-Conter C, Jouvet A, Giannini C, Nageswara Rao AA, Li KKW, Ng HK, Eberhart CG, Pollack IF, Hamilton RL, Gillespie GY, Olson JM, Leary S, Weiss WA, Lach B, Chambless LB, Thompson RC, Cooper MK, Vibhakar R, Hauser P, van Veelen MC, Kros JM, French PJ, Ra YS, Kumabe T, López-Aguilar E, Zitterbart K, Sterba J, Finocchiaro G, Massimino M, Van Meir EG, Osuka S, Shofuda T, Klekner A, Zollo M, Leonard JR, Rubin JB, Jabado N, Albrecht S, Mora J, Van Meter TE, Jung S, Moore AS, Hallahan AR, Chan JA, Tirapelli DPC, Carlotti CG, Fouladi M, Pimentel J, Faria CC, Saad AG, Massimi L, Liau LM, Wheeler H, Nakamura H, Elbabaa SK, Perezpeña-Diazconti M, Chico Ponce de León F, Robinson S, Zapotocky M, Lassaletta A, Huang A, Hawkins CE, Tabori U, Bouffet E, Bartels U, Dirks PB, Rutka JT, Bader GD, Reimand J, Goldenberg A, Ramaswamy V, Taylor MD
Cancer Cell 2017 Jun 12;31(6):737-754.e6. doi: 10.1016/j.ccell.2017.05.005. PMID: 28609654Free PMC Article
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article

Diagnosis

Medulloblastoma: WHO 2021 and Beyond.
Cotter JA, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):23-33. doi: 10.1177/10935266211018931. PMID: 35168417
Pathology, diagnostics, and classification of medulloblastoma.
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article

Therapy

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.
Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK
Cancer Cell 2022 Dec 12;40(12):1488-1502.e7. Epub 2022 Nov 10 doi: 10.1016/j.ccell.2022.10.009. PMID: 36368321
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Medulloblastoma stem cells.
Fan X, Eberhart CG
J Clin Oncol 2008 Jun 10;26(17):2821-7. doi: 10.1200/JCO.2007.15.2264. PMID: 18539960Free PMC Article

Prognosis

Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article

Clinical prediction guides

MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang M, Wong SW, Wright JN, Wagner MW, Toescu S, Han M, Tam LT, Zhou Q, Ahmadian SS, Shpanskaya K, Lummus S, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S 2nd, Malinzak M, Laughlin S, Perreault S, Braun KRM, Lober RM, Cho YJ, Ertl-Wagner B, Ho CY, Mankad K, Vogel H, Cheshier SH, Jacques TS, Aquilina K, Fisher PG, Taylor M, Poussaint T, Vitanza NA, Grant GA, Pfister S, Thompson E, Jaju A, Ramaswamy V, Yeom KW
Radiology 2022 Aug;304(2):406-416. Epub 2022 Apr 19 doi: 10.1148/radiol.212137. PMID: 35438562Free PMC Article
Children's Oncology Group Phase III Trial of Reduced-Dose and Reduced-Volume Radiotherapy With Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma.
Michalski JM, Janss AJ, Vezina LG, Smith KS, Billups CA, Burger PC, Embry LM, Cullen PL, Hardy KK, Pomeroy SL, Bass JK, Perkins SM, Merchant TE, Colte PD, Fitzgerald TJ, Booth TN, Cherlow JM, Muraszko KM, Hadley J, Kumar R, Han Y, Tarbell NJ, Fouladi M, Pollack IF, Packer RJ, Li Y, Gajjar A, Northcott PA
J Clin Oncol 2021 Aug 20;39(24):2685-2697. Epub 2021 Jun 10 doi: 10.1200/JCO.20.02730. PMID: 34110925Free PMC Article
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
Gajjar A, Robinson GW, Smith KS, Lin T, Merchant TE, Chintagumpala M, Mahajan A, Su J, Bouffet E, Bartels U, Schechter T, Hassall T, Robertson T, Nicholls W, Gururangan S, Schroeder K, Sullivan M, Wheeler G, Hansford JR, Kellie SJ, McCowage G, Cohn R, Fisher MJ, Krasin MJ, Stewart CF, Broniscer A, Buchhalter I, Tatevossian RG, Orr BA, Neale G, Klimo P Jr, Boop F, Srinivasan A, Pfister SM, Gilbertson RJ, Onar-Thomas A, Ellison DW, Northcott PA
J Clin Oncol 2021 Mar 1;39(7):822-835. Epub 2021 Jan 6 doi: 10.1200/JCO.20.01372. PMID: 33405951Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Quality of life in survivors of pediatric medulloblastoma: a systematic review and meta-analysis.
Baqai MWS, Tariq R, Shah Z, Bajwa MH, Shamim MS
Childs Nerv Syst 2023 May;39(5):1159-1171. Epub 2023 Feb 24 doi: 10.1007/s00381-023-05886-4. PMID: 36826523
Functional tracts of the cerebellum-essentials for the neurosurgeon.
Beez T, Munoz-Bendix C, Steiger HJ, Hänggi D
Neurosurg Rev 2021 Feb;44(1):273-278. Epub 2020 Feb 13 doi: 10.1007/s10143-020-01242-1. PMID: 32056026Free PMC Article
Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
Bautista F, Fioravantti V, de Rojas T, Carceller F, Madero L, Lassaletta A, Moreno L
Cancer Med 2017 Nov;6(11):2606-2624. Epub 2017 Oct 4 doi: 10.1002/cam4.1171. PMID: 28980418Free PMC Article
Re-irradiation for Recurrent Primary Brain Tumors.
Nieder C, Andratschke NH, Grosu AL
Anticancer Res 2016 Oct;36(10):4985-4995. doi: 10.21873/anticanres.11067. PMID: 27798857
Chemotherapy for children with medulloblastoma.
Michiels EM, Schouten-Van Meeteren AY, Doz F, Janssens GO, van Dalen EC
Cochrane Database Syst Rev 2015 Jan 1;1(1):CD006678. doi: 10.1002/14651858.CD006678.pub2. PMID: 25879092Free PMC Article

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