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Anti-lamin A antibody positivity

MedGen UID:: 1052533
•Concept ID:: CN377475
•: Finding

Synonyms:	ki-67 antibody positivity; LMNA antibody positivity; PCNA antibody positivity; Prelamin A antibody positivity

HPO:	HP:6000643

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against lamin A. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAnti-lamin A antibody positivity

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormality of immune system physiology
    - Autoimmunity
      - Autoimmune antibody positivity
        Anti-lamin A antibody positivity

Recent clinical studies

Therapy

Acute hepatitis caused by alverine associated with anti-lamin A and C autoantibodies.

Malka D, Pham BN, Courvalin JC, Corbic M, Pessayre D, Erlinger S
J Hepatol 1997 Aug;27(2):399-403. doi: 10.1016/s0168-8278(97)80187-0. PMID: 9288616

Prognosis

Acute hepatitis caused by alverine associated with anti-lamin A and C autoantibodies.

Malka D, Pham BN, Courvalin JC, Corbic M, Pessayre D, Erlinger S
J Hepatol 1997 Aug;27(2):399-403. doi: 10.1016/s0168-8278(97)80187-0. PMID: 9288616

Clinical prediction guides

Vitiligo autoantigen VIT75 is identified as lamin A in vitiligo by serological proteome analysis based on mass spectrometry.

Li Q, Lv Y, Li C, Yi X, Long HA, Qiao H, Lu T, Luan Q, Li K, Wang X, Wang G, Gao T
J Invest Dermatol 2011 Mar;131(3):727-34. Epub 2010 Nov 18 doi: 10.1038/jid.2010.341. PMID: 21085190

Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis.

Muratori P, Muratori L, Ferrari R, Cassani F, Bianchi G, Lenzi M, Rodrigo L, Linares A, Fuentes D, Bianchi FB
Am J Gastroenterol 2003 Feb;98(2):431-7. doi: 10.1111/j.1572-0241.2003.07257.x. PMID: 12591064

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