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Abnormal circulating interleukin 6 concentration

MedGen UID:
1052623
•Concept ID:
CN377043
•
Finding
HPO: HP:6000441

Definition

Any deviation from the normal range of the concentration of interleukin 6 (IL-6) in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy.
He J, Liu B, Du X, Wei Y, Kong D, Feng B, Guo R, Asiamah EA, Griffin MD, Hynes SO, Shen S, Liu Y, Cui H, Ma J, O'Brien T
Stem Cell Res Ther 2024 Mar 5;15(1):66. doi: 10.1186/s13287-024-03647-x. PMID: 38443965Free PMC Article
Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Rethinking Immunity and Cognition in Clinical High Risk for Psychosis.
Griffiths SL, Upthegrove R, Corsi-Zuelli F, Deakin B
Curr Top Behav Neurosci 2023;63:475-497. doi: 10.1007/7854_2022_399. PMID: 36409457
Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.
Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19.
Grondman I, de Nooijer AH, Antonakos N, Janssen NAF, Mouktaroudi M, Leventogiannis K, Medici M, Smit JWA, van Herwaarden AE, Joosten LAB, van de Veerdonk FL, Pickkers P, Kox M, Jaeger M, Netea MG, Giamarellos-Bourboulis EJ, Netea-Maier RT
J Clin Endocrinol Metab 2021 Jun 16;106(7):1994-2009. doi: 10.1210/clinem/dgab148. PMID: 33713408Free PMC Article
Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.
Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111
Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation.
Miyaoka K, Iwase M, Suzuki R, Kondo G, Watanabe H, Ito D, Nagumo M
J Surg Res 2005 May 15;125(2):144-50. doi: 10.1016/j.jss.2004.12.001. PMID: 15854666
Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients.
Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI
Hepatology 1991 Feb;13(2):267-76. PMID: 1995437

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.
Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111
Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression.
Fitzgerald P, O'Brien SM, Scully P, Rijkers K, Scott LV, Dinan TG
Psychol Med 2006 Jan;36(1):37-43. Epub 2005 Oct 28 doi: 10.1017/S003329170500632X. PMID: 16255837
Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation.
Miyaoka K, Iwase M, Suzuki R, Kondo G, Watanabe H, Ito D, Nagumo M
J Surg Res 2005 May 15;125(2):144-50. doi: 10.1016/j.jss.2004.12.001. PMID: 15854666
Serum interleukin-6 in amiodarone-induced thyrotoxicosis.
Bartalena L, Grasso L, Brogioni S, Aghini-Lombardi F, Braverman LE, Martino E
J Clin Endocrinol Metab 1994 Feb;78(2):423-7. doi: 10.1210/jcem.78.2.8106631. PMID: 8106631

Prognosis

Relationship of fibroblast growth factor 21 levels with inflammation, lipoproteins and non-alcoholic fatty liver disease.
Tucker B, McClelland RL, Allison MA, Budoff MJ, Wu BJ, Barter PJ, Rye KA, Ong KL
Atherosclerosis 2020 Apr;299:38-44. Epub 2020 Mar 16 doi: 10.1016/j.atherosclerosis.2020.03.009. PMID: 32220662
Local inflammation occurs before systemic inflammation in patients with COPD.
He Z, Chen Y, Chen P, Wu G, Cai S
Respirology 2010 Apr;15(3):478-84. Epub 2010 Feb 24 doi: 10.1111/j.1440-1843.2010.01709.x. PMID: 20210891
Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation.
Miyaoka K, Iwase M, Suzuki R, Kondo G, Watanabe H, Ito D, Nagumo M
J Surg Res 2005 May 15;125(2):144-50. doi: 10.1016/j.jss.2004.12.001. PMID: 15854666
Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock.
Hoen S, Asehnoune K, Brailly-Tabard S, Mazoit JX, Benhamou D, Moine P, Edouard AR
Anesthesiology 2002 Oct;97(4):807-13. doi: 10.1097/00000542-200210000-00010. PMID: 12357144
Levels of circulating antiinflammatory cytokine interleukin-1 receptor antagonist and proinflammatory cytokines at different stages of biliary atresia.
Kobayashi H, Yamataka A, Lane GJ, Miyano T
J Pediatr Surg 2002 Jul;37(7):1038-41. doi: 10.1053/jpsu.2002.33840. PMID: 12077767

Clinical prediction guides

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1β, IL-6 and IL-8.
Bester J, Matshailwe C, Pretorius E
Cytokine 2018 Oct;110:237-242. Epub 2018 Feb 1 doi: 10.1016/j.cyto.2018.01.007. PMID: 29396046
Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.
Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111
Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation.
Miyaoka K, Iwase M, Suzuki R, Kondo G, Watanabe H, Ito D, Nagumo M
J Surg Res 2005 May 15;125(2):144-50. doi: 10.1016/j.jss.2004.12.001. PMID: 15854666
Elevated pyrogenic cytokines in heatstroke.
Bouchama A, al-Sedairy S, Siddiqui S, Shail E, Rezeig M
Chest 1993 Nov;104(5):1498-502. doi: 10.1378/chest.104.5.1498. PMID: 8222814

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118

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