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Esophageal fibrosis

MedGen UID:
1052649
•Concept ID:
CN376577
•
Finding
HPO: HP:6000065

Definition

Fibrosis located in the subepithelial portion of the esophagus. Fibrosisis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal fibrosis

Professional guidelines

PubMed

Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.
Goyal R, Kamboj AK, Snyder DL
Mayo Clin Proc 2024 Apr;99(4):640-648. doi: 10.1016/j.mayocp.2023.12.026. PMID: 38569813
Novel corticosteroid formulations in the treatment of eosinophilic esophagitis: what is the evidence?
Walgraeve S, Vanuytsel T
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):437-448. doi: 10.51821/86.3.11757. PMID: 37814560
Medical and nutrition management of eosinophilic esophagitis in children.
Feuling MB, Noel RJ
Nutr Clin Pract 2010 Apr;25(2):166-74. doi: 10.1177/0884533610361608. PMID: 20413697

Recent clinical studies

Etiology

Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.
Goyal R, Kamboj AK, Snyder DL
Mayo Clin Proc 2024 Apr;99(4):640-648. doi: 10.1016/j.mayocp.2023.12.026. PMID: 38569813
Protective effect of rosuvastatin against the formation of benign esophageal stricture.
Zhu B, Song B, Wang Y, Bao M, Cheng W, Zhang W, Liu M, Gong Y
Esophagus 2022 Apr;19(2):343-350. Epub 2021 Nov 20 doi: 10.1007/s10388-021-00895-1. PMID: 34800196
Proton pump inhibitor therapy reverses endoscopic features of fibrosis in eosinophilic esophagitis.
Navarro P, Laserna-Mendieta EJ, Guagnozzi D, Casabona S, Perelló A, Savarino E, de la Riva S, Olalla JM, Ghisa M, Serrano-Moya N, Alcolea-Valero C, Ortega-Rabbione G, Majano P, Santander C, Arias Á, Lucendo AJ; EUREOS EoE CONNECT research group
Dig Liver Dis 2021 Nov;53(11):1479-1485. Epub 2021 Jun 10 doi: 10.1016/j.dld.2021.05.025. PMID: 34120859
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures.
Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M
Arthritis Res Ther 2015 Jul 29;17:194. doi: 10.1186/s13075-015-0695-1. PMID: 26220546Free PMC Article
Dietary therapy can reverse esophageal subepithelial fibrosis in patients with eosinophilic esophagitis: a historical cohort.
Lieberman JA, Morotti RA, Konstantinou GN, Yershov O, Chehade M
Allergy 2012 Oct;67(10):1299-307. Epub 2012 Aug 23 doi: 10.1111/j.1398-9995.2012.02881.x. PMID: 22913672

Diagnosis

Esophageal remodeling in eosinophilic esophagitis.
Shaker A
Curr Opin Gastroenterol 2024 Jul 1;40(4):291-298. Epub 2024 Apr 12 doi: 10.1097/MOG.0000000000001031. PMID: 38661722Free PMC Article
Eosinophilic esophagitis an update in children.
Votto M, Naso M, Clemente AM, De Filippo M, Gargiulo G, Granone V, Siri G, Marseglia GL, Licari A
Acta Biomed 2022 Jun 6;93(S3):e2022034. doi: 10.23750/abm.v93iS3.13068. PMID: 35666120Free PMC Article
Esophageal Fibrosis in Eosinophilic Gastrointestinal Diseases.
Thaker AI, Melo DM, Samandi LZ, Huang R, Park JY, Cheng E
J Pediatr Gastroenterol Nutr 2021 Mar 1;72(3):392-397. doi: 10.1097/MPG.0000000000002997. PMID: 33230074
Eosinophilic Esophagitis.
Katzka DA
Ann Intern Med 2020 May 5;172(9):ITC65-ITC80. doi: 10.7326/AITC202005050. PMID: 32365374
Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis.
Muir AB, Wang JX, Nakagawa H
J Gastroenterol 2019 Jan;54(1):10-18. Epub 2018 Aug 12 doi: 10.1007/s00535-018-1498-3. PMID: 30101408Free PMC Article

Therapy

Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.
Goyal R, Kamboj AK, Snyder DL
Mayo Clin Proc 2024 Apr;99(4):640-648. doi: 10.1016/j.mayocp.2023.12.026. PMID: 38569813
Eosinophilic esophagitis an update in children.
Votto M, Naso M, Clemente AM, De Filippo M, Gargiulo G, Granone V, Siri G, Marseglia GL, Licari A
Acta Biomed 2022 Jun 6;93(S3):e2022034. doi: 10.23750/abm.v93iS3.13068. PMID: 35666120Free PMC Article
Eosinophilic Esophagitis.
Katzka DA
Ann Intern Med 2020 May 5;172(9):ITC65-ITC80. doi: 10.7326/AITC202005050. PMID: 32365374
Dietary therapy can reverse esophageal subepithelial fibrosis in patients with eosinophilic esophagitis: a historical cohort.
Lieberman JA, Morotti RA, Konstantinou GN, Yershov O, Chehade M
Allergy 2012 Oct;67(10):1299-307. Epub 2012 Aug 23 doi: 10.1111/j.1398-9995.2012.02881.x. PMID: 22913672
Medical and nutrition management of eosinophilic esophagitis in children.
Feuling MB, Noel RJ
Nutr Clin Pract 2010 Apr;25(2):166-74. doi: 10.1177/0884533610361608. PMID: 20413697

Prognosis

Esophageal remodeling in eosinophilic esophagitis.
Shaker A
Curr Opin Gastroenterol 2024 Jul 1;40(4):291-298. Epub 2024 Apr 12 doi: 10.1097/MOG.0000000000001031. PMID: 38661722Free PMC Article
Monitoring and modulating the trajectory of eosinophilic esophagitis.
Pomenti SF, Bailey DD, Katzka DA
J Allergy Clin Immunol 2024 Jun;153(6):1465-1471. Epub 2024 Apr 2 doi: 10.1016/j.jaci.2024.03.012. PMID: 38570041
Proton pump inhibitor therapy reverses endoscopic features of fibrosis in eosinophilic esophagitis.
Navarro P, Laserna-Mendieta EJ, Guagnozzi D, Casabona S, Perelló A, Savarino E, de la Riva S, Olalla JM, Ghisa M, Serrano-Moya N, Alcolea-Valero C, Ortega-Rabbione G, Majano P, Santander C, Arias Á, Lucendo AJ; EUREOS EoE CONNECT research group
Dig Liver Dis 2021 Nov;53(11):1479-1485. Epub 2021 Jun 10 doi: 10.1016/j.dld.2021.05.025. PMID: 34120859
Dietary therapy can reverse esophageal subepithelial fibrosis in patients with eosinophilic esophagitis: a historical cohort.
Lieberman JA, Morotti RA, Konstantinou GN, Yershov O, Chehade M
Allergy 2012 Oct;67(10):1299-307. Epub 2012 Aug 23 doi: 10.1111/j.1398-9995.2012.02881.x. PMID: 22913672
Utility of bronchoalveolar lavage in evaluation of patients with connective tissue diseases.
Kowal-Bielecka O, Kowal K, Chyczewska E
Clin Chest Med 2010 Sep;31(3):423-31. doi: 10.1016/j.ccm.2010.04.002. PMID: 20692537

Clinical prediction guides

Esophageal remodeling in eosinophilic esophagitis.
Shaker A
Curr Opin Gastroenterol 2024 Jul 1;40(4):291-298. Epub 2024 Apr 12 doi: 10.1097/MOG.0000000000001031. PMID: 38661722Free PMC Article
Extracellular matrix remodeling proteins as biomarkers for clinical assessment and treatment outcomes in eosinophilic esophagitis.
Pehrsson M, de Rooij WE, Bay-Jensen AC, Karsdal MA, Mortensen JH, Bredenoord AJ
BMC Gastroenterol 2023 Oct 16;23(1):357. doi: 10.1186/s12876-023-02977-z. PMID: 37845632Free PMC Article
Esophageal Fibrosis in Eosinophilic Gastrointestinal Diseases.
Thaker AI, Melo DM, Samandi LZ, Huang R, Park JY, Cheng E
J Pediatr Gastroenterol Nutr 2021 Mar 1;72(3):392-397. doi: 10.1097/MPG.0000000000002997. PMID: 33230074
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures.
Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M
Arthritis Res Ther 2015 Jul 29;17:194. doi: 10.1186/s13075-015-0695-1. PMID: 26220546Free PMC Article
Utility of bronchoalveolar lavage in evaluation of patients with connective tissue diseases.
Kowal-Bielecka O, Kowal K, Chyczewska E
Clin Chest Med 2010 Sep;31(3):423-31. doi: 10.1016/j.ccm.2010.04.002. PMID: 20692537

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