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Third cranial nerve thickening

MedGen UID:
1052658
•Concept ID:
CN377102
•
Finding
Synonym: Oculomotor nerve thickening
 
HPO: HP:6000291

Definition

Increase in diameter of the third cranial nerve (oculomotor nerve). This feature can be observed by magnetic resonance imaging and may be accompanied by contrast enhancement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThird cranial nerve thickening

Professional guidelines

PubMed

Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia.
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798

Recent clinical studies

Etiology

Cavernous Sinus MRI Findings in Inflammatory and Ischemic Oculomotor Cranial Nerve Palsies.
Yunqing W, Shilei C, Yong L, Qing L, Xiaohong S, Jiawei W
J Neuroophthalmol 2024 Jun 1;44(2):236-241. Epub 2023 Sep 25 doi: 10.1097/WNO.0000000000001958. PMID: 37751328Free PMC Article
Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure.
Furtado LMF, da Costa Val Filho JA, Holliday JB, da Silva Costa J, de Matos MA, Nascimento VAM, Ramos Cavalcanti T
Childs Nerv Syst 2020 Dec;36(12):3047-3052. Epub 2020 Apr 4 doi: 10.1007/s00381-020-04596-5. PMID: 32248278
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Idiopathic hypertrophic cranial pachymeningitis.
Rojana-udomsart A, Pulkes T, Viranuwatti K, Laothamatas J, Phudhichareonrat S, Witoonpanich R
J Clin Neurosci 2008 Apr;15(4):465-9. Epub 2008 Jan 30 doi: 10.1016/j.jocn.2006.11.020. PMID: 18249120

Diagnosis

Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia.
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270

Therapy

An 11-month-old boy with tuberculous meningitis presenting as progressive limb weakness, fever, developmental retardation, and loss of consciousness: a case report.
Sharifi G, Ansari M, Chalmiani EM, Javandoust Gharehbagh F, Darazam IA
J Med Case Rep 2024 Apr 27;18(1):210. doi: 10.1186/s13256-024-04523-1. PMID: 38671477Free PMC Article
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Microsurgical findings of Tolosa-Hunt syndrome.
Kodera T, Takeuchi H, Arishima H, Tsunetoshi K, Kitai R, Arai Y, Kikuta K, Hamano T, Kuronuma Y
World Neurosurg 2013 Mar-Apr;79(3-4):594.e1-4. Epub 2012 Apr 3 doi: 10.1016/j.wneu.2012.03.025. PMID: 22484067
Granulomatous meningitis.
Loy ST, Tan CW
Singapore Med J 2009 Nov;50(11):e371-3. PMID: 19960146
Transient oculomotor nerve synkinesis in non-Hodgkin's lymphoma.
Lee SH, Yeow YK, Tan CB, Tjia H
J Clin Neuroophthalmol 1992 Sep;12(3):203-6. PMID: 1401168

Prognosis

A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure.
Furtado LMF, da Costa Val Filho JA, Holliday JB, da Silva Costa J, de Matos MA, Nascimento VAM, Ramos Cavalcanti T
Childs Nerv Syst 2020 Dec;36(12):3047-3052. Epub 2020 Apr 4 doi: 10.1007/s00381-020-04596-5. PMID: 32248278
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Microsurgical findings of Tolosa-Hunt syndrome.
Kodera T, Takeuchi H, Arishima H, Tsunetoshi K, Kitai R, Arai Y, Kikuta K, Hamano T, Kuronuma Y
World Neurosurg 2013 Mar-Apr;79(3-4):594.e1-4. Epub 2012 Apr 3 doi: 10.1016/j.wneu.2012.03.025. PMID: 22484067
Ophthalmoplegic migraine: a recurrent demyelinating neuropathy?
Lance JW, Zagami AS
Cephalalgia 2001 Mar;21(2):84-9. doi: 10.1046/j.1468-2982.2001.00160.x. PMID: 11422088

Clinical prediction guides

Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure.
Furtado LMF, da Costa Val Filho JA, Holliday JB, da Silva Costa J, de Matos MA, Nascimento VAM, Ramos Cavalcanti T
Childs Nerv Syst 2020 Dec;36(12):3047-3052. Epub 2020 Apr 4 doi: 10.1007/s00381-020-04596-5. PMID: 32248278
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270
Magnetic resonance imaging of the functional anatomy of the inferior oblique muscle in superior oblique palsy.
Kono R, Demer JL
Ophthalmology 2003 Jun;110(6):1219-29. doi: 10.1016/S0161-6420(03)00331-2. PMID: 12799250

Recent systematic reviews

Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article
Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ
J Child Neurol 2012 Jun;27(6):759-66. Epub 2012 Jan 12 doi: 10.1177/0883073811426502. PMID: 22241707Free PMC Article

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