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Elevated circulating chitotriosidase activity

MedGen UID:
1052961
•Concept ID:
CN377443
•
Finding
HPO: HP:6000611

Definition

Increased activity or concentration of the enzyme chitotriosidase. Serum chitotriosidase is a biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating chitotriosidase activity

Professional guidelines

PubMed

Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors.
Pedersen SJ, Hetland ML, Sørensen IJ, Ostergaard M, Nielsen HJ, Johansen JS
Clin Rheumatol 2010 Nov;29(11):1301-9. Epub 2010 Jul 18 doi: 10.1007/s10067-010-1528-x. PMID: 20640910

Recent clinical studies

Etiology

Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X
Redox Biol 2022 Dec;58:102538. Epub 2022 Nov 12 doi: 10.1016/j.redox.2022.102538. PMID: 36417796Free PMC Article
Evaluation of Chitotriosidase as a Marker of Inflammatory Status in Critical Limb Ischemia.
Ciocan RA, Drugan C, Gherman CD, Cătană CS, Ciocan A, Drugan TC, Bolboacă SD
Ann Clin Lab Sci 2017 Nov;47(6):713-719. PMID: 29263045
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium
Am J Respir Crit Care Med 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC. PMID: 26372680
Plasma YKL-40 during pregnancy and gestational diabetes mellitus.
Rinnov AR, Rathcke CN, Bonde L, Vilsbøll T, Knop FK
J Reprod Immunol 2015 Nov;112:68-72. Epub 2015 Jul 14 doi: 10.1016/j.jri.2015.06.092. PMID: 26301577
Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children.
Kyrgios I, Galli-Tsinopoulou A, Stylianou C, Papakonstantinou E, Arvanitidou M, Haidich AB
Metabolism 2012 Apr;61(4):562-8. Epub 2011 Oct 27 doi: 10.1016/j.metabol.2011.09.004. PMID: 22036069

Diagnosis

Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis.
Esen I, Jiemy WF, van Sleen Y, Bijzet J, de Jong DM, Nienhuis PH, Slart RHJA, Heeringa P, Boots AMH, Brouwer E
Rheumatology (Oxford) 2022 Jul 6;61(7):3060-3070. doi: 10.1093/rheumatology/keab814. PMID: 34730794Free PMC Article
Relationships between increased circulating YKL-40, IL-6 and TNF-α levels and phenotypes and disease activity of primary Sjögren's syndrome.
Chen C, Liang Y, Zhang Z, Zhang Z, Yang Z
Int Immunopharmacol 2020 Nov;88:106878. Epub 2020 Aug 10 doi: 10.1016/j.intimp.2020.106878. PMID: 32791244
Evaluation of Chitotriosidase as a Marker of Inflammatory Status in Critical Limb Ischemia.
Ciocan RA, Drugan C, Gherman CD, Cătană CS, Ciocan A, Drugan TC, Bolboacă SD
Ann Clin Lab Sci 2017 Nov;47(6):713-719. PMID: 29263045
Characterisation of asthma subgroups associated with circulating YKL-40 levels.
Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL; SARP Investigators
Eur Respir J 2017 Oct;50(4) Epub 2017 Oct 12 doi: 10.1183/13993003.00800-2017. PMID: 29025889Free PMC Article
Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children.
Kyrgios I, Galli-Tsinopoulou A, Stylianou C, Papakonstantinou E, Arvanitidou M, Haidich AB
Metabolism 2012 Apr;61(4):562-8. Epub 2011 Oct 27 doi: 10.1016/j.metabol.2011.09.004. PMID: 22036069

Therapy

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium
Am J Respir Crit Care Med 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC. PMID: 26372680
Plasma YKL-40 during pregnancy and gestational diabetes mellitus.
Rinnov AR, Rathcke CN, Bonde L, Vilsbøll T, Knop FK
J Reprod Immunol 2015 Nov;112:68-72. Epub 2015 Jul 14 doi: 10.1016/j.jri.2015.06.092. PMID: 26301577
Adverse local tissue reaction (ALTR) associated with corrosion products in metal-on-metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma-mediated chemokine signaling.
Kolatat K, Perino G, Wilner G, Kaplowitz E, Ricciardi BF, Boettner F, Westrich GH, Jerabek SA, Goldring SR, Purdue PE
J Orthop Res 2015 Oct;33(10):1487-97. Epub 2015 May 18 doi: 10.1002/jor.22916. PMID: 25940887

Prognosis

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium
Am J Respir Crit Care Med 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC. PMID: 26372680
Plasma YKL-40 during pregnancy and gestational diabetes mellitus.
Rinnov AR, Rathcke CN, Bonde L, Vilsbøll T, Knop FK
J Reprod Immunol 2015 Nov;112:68-72. Epub 2015 Jul 14 doi: 10.1016/j.jri.2015.06.092. PMID: 26301577
Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias.
Korthagen NM, van Moorsel CH, Zanen P, Ruven HJ, Grutters JC
Lung 2014 Dec;192(6):975-80. Epub 2014 Oct 2 doi: 10.1007/s00408-014-9647-9. PMID: 25274153

Clinical prediction guides

Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis.
Esen I, Jiemy WF, van Sleen Y, Bijzet J, de Jong DM, Nienhuis PH, Slart RHJA, Heeringa P, Boots AMH, Brouwer E
Rheumatology (Oxford) 2022 Jul 6;61(7):3060-3070. doi: 10.1093/rheumatology/keab814. PMID: 34730794Free PMC Article
Peripheral blood mononuclear cell response to YKL-40 and Galectin-3 in cystic fibrosis.
Bouvet GF, Bulka O, Coriati A, Sognigbé L, St-Pierre G, Massé C, Sato S, Berthiaume Y
Cytokine 2021 Oct;146:155635. Epub 2021 Jul 15 doi: 10.1016/j.cyto.2021.155635. PMID: 34274729
Relationships between increased circulating YKL-40, IL-6 and TNF-α levels and phenotypes and disease activity of primary Sjögren's syndrome.
Chen C, Liang Y, Zhang Z, Zhang Z, Yang Z
Int Immunopharmacol 2020 Nov;88:106878. Epub 2020 Aug 10 doi: 10.1016/j.intimp.2020.106878. PMID: 32791244
Evaluation of Chitotriosidase as a Marker of Inflammatory Status in Critical Limb Ischemia.
Ciocan RA, Drugan C, Gherman CD, Cătană CS, Ciocan A, Drugan TC, Bolboacă SD
Ann Clin Lab Sci 2017 Nov;47(6):713-719. PMID: 29263045
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium
Am J Respir Crit Care Med 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC. PMID: 26372680

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