U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CSF oligoclonal immunoglobulin G bands

MedGen UID:
1052965
Concept ID:
CN376993
Finding
HPO: HP:6000397

Definition

Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent a hallmark of multiple sclerosis (MS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCSF oligoclonal immunoglobulin G bands

Professional guidelines

PubMed

Taşkıran E, Terzi M, Helvacı EM, Eser MZ, Avcı B, Ömer Faruk T, Yetkin MF, Çilingir V, Bir LS, Kabay SC, Bilge N, Poyraz T, Demir CF, Dündar DK, Ocak Ö, Çam M, Mavioğlu H, Altun Y, Karaibrahimoğlu A
Mult Scler Relat Disord 2024 Mar;83:105391. Epub 2024 Jan 27 doi: 10.1016/j.msard.2023.105391. PMID: 38335838
Hegen H, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):182-195. Epub 2022 Dec 17 doi: 10.1177/13524585221134217. PMID: 36527368Free PMC Article
Carta S, Ferraro D, Ferrari S, Briani C, Mariotto S
Crit Rev Clin Lab Sci 2022 Sep;59(6):391-404. Epub 2022 Mar 11 doi: 10.1080/10408363.2022.2039591. PMID: 35277112

Recent clinical studies

Etiology

Dekeyser C, Hautekeete M, Cambron M, Van Pesch V, Patti F, Kuhle J, Khoury S, Lechner Scott J, Gerlach O, Lugaresi A, Maimone D, Surcinelli A, Grammond P, Kalincik T, Habek M, Willekens B, Macdonell R, Lalive P, Csepany T, Butzkueven H, Boz C, Tomassini V, Foschi M, Sánchez-Menoyo JL, Altintas A, Mrabet S, Iuliano G, Sa MJ, Alroughani R, Karabudak R, Aguera-Morales E, Gray O, de Gans K, van der Walt A, McCombe PA, Deri N, Garber J, Al-Asmi A, Skibina O, Duquette P, Cartechini E, Spitaleri D, Gouider R, Soysal A, Van Hijfte L, Slee M, Amato MP, Buzzard K, Laureys G
J Neurol Neurosurg Psychiatry 2024 Oct 16;95(11):1021-1031. doi: 10.1136/jnnp-2023-333307. PMID: 38569872
Olivé-Cirera G, Bruijstens AL, Fonseca EG, Chen LW, Caballero E, Martinez-Hernandez E, Guasp M, Sepúlveda M, Naranjo L, Ruiz-García R, Blanco Y, Saiz A, Dalmau JO, Armangue T; Spanish Pediatric MOGAD Study Group
Neurology 2024 Apr 9;102(7):e209199. Epub 2024 Mar 6 doi: 10.1212/WNL.0000000000209199. PMID: 38447115
Quack L, Glatter S, Wegener-Panzer A, Cleaveland R, Bertolini A, Endmayr V, Seidl R, Breu M, Wendel E, Schimmel M, Baumann M, Rauchenzauner M, Pritsch M, Boy N, Muralter T, Kluger G, Makoswski C, Kraus V, Leiz S, Loehr-Nilles C, Kreth JH, Braig S, Schilling S, Kern J, Blank C, Tro Baumann B, Vieth S, Wallot M, Reindl M, Ringl H, Wandinger KP, Leypoldt F, Höftberger R, Rostásy K
Eur J Paediatr Neurol 2023 Nov;47:118-130. Epub 2023 Oct 20 doi: 10.1016/j.ejpn.2023.10.005. PMID: 38284996
Ayroza Galvão Ribeiro Gomes AB, Kulsvehagen L, Lipps P, Cagol A, Cerdá-Fuertes N, Neziraj T, Flammer J, Lerner J, Lecourt AC, de Oliveira S Siebenborn N, Cortese R, Schaedelin S, Andreoli Schoeps V, de Moura Brasil Matos A, Trombini Mendes N, Dos Reis Pereira C, Ribeiro Monteiro ML, Dos Apóstolos-Pereira SL, Schindler P, Chien C, Schwake C, Schneider R, Pakeerathan T, Aktas O, Fischer U, Mehling M, Derfuss T, Kappos L, Ayzenberg I, Ringelstein M, Paul F, Callegaro D, Kuhle J, Papadopoulou A, Granziera C, Pröbstel AK
JAMA Neurol 2023 Sep 1;80(9):989-995. doi: 10.1001/jamaneurol.2023.2523. PMID: 37548987Free PMC Article
Cacciaguerra L, Morris P, Tobin WO, Chen JJ, Banks SA, Elsbernd P, Redenbaugh V, Tillema JM, Montini F, Sechi E, Lopez-Chiriboga AS, Zalewski N, Guo Y, Rocca MA, Filippi M, Pittock SJ, Lucchinetti CF, Flanagan EP
Neurology 2023 Mar 28;100(13):e1418-e1432. Epub 2023 Jan 23 doi: 10.1212/WNL.0000000000206820. PMID: 36690455Free PMC Article

Diagnosis

Willis MD, Kreft KL, Dancey B
Pract Neurol 2024 Sep 13;24(5):400-406. doi: 10.1136/pn-2023-003814. PMID: 38937092
Hegen H, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):182-195. Epub 2022 Dec 17 doi: 10.1177/13524585221134217. PMID: 36527368Free PMC Article
Hegen H, Walde J, Berek K, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):169-181. Epub 2022 Dec 1 doi: 10.1177/13524585221134213. PMID: 36453167Free PMC Article
Cabrera CM
Adv Clin Chem 2022;109:129-163. Epub 2022 Apr 22 doi: 10.1016/bs.acc.2022.03.004. PMID: 35953125
Carta S, Ferraro D, Ferrari S, Briani C, Mariotto S
Crit Rev Clin Lab Sci 2022 Sep;59(6):391-404. Epub 2022 Mar 11 doi: 10.1080/10408363.2022.2039591. PMID: 35277112

Therapy

Taşkıran E, Terzi M, Helvacı EM, Eser MZ, Avcı B, Ömer Faruk T, Yetkin MF, Çilingir V, Bir LS, Kabay SC, Bilge N, Poyraz T, Demir CF, Dündar DK, Ocak Ö, Çam M, Mavioğlu H, Altun Y, Karaibrahimoğlu A
Mult Scler Relat Disord 2024 Mar;83:105391. Epub 2024 Jan 27 doi: 10.1016/j.msard.2023.105391. PMID: 38335838
Bellucci M, Castellano C, Marinelli L, Garbarino L, Gastaldi M, Franciotta D, Benedetti L
Neurology 2024 Feb 13;102(3):e208110. Epub 2024 Jan 11 doi: 10.1212/WNL.0000000000208110. PMID: 38207275
Yoo JE, Shin HJ, Kang HC, Lee JS, Kim HD, Lee HN
Yonsei Med J 2023 Nov;64(11):692-695. doi: 10.3349/ymj.2023.0202. PMID: 37880851Free PMC Article
Schlüter M, Oswald E, Winklmeier S, Meinl I, Havla J, Eichhorn P, Meinl E, Kümpfel T
Neurol Neuroimmunol Neuroinflamm 2021 Jul;8(5) Epub 2021 Jul 1 doi: 10.1212/NXI.0000000000001030. PMID: 34210800Free PMC Article
Zhu F, Shan W, Lv R, Li Z, Wang Q
Acta Neurol Scand 2020 Sep;142(3):281-293. Epub 2020 Jun 15 doi: 10.1111/ane.13281. PMID: 32416610

Prognosis

Maroto-García J, Martínez-Escribano A, Delgado-Gil V, Mañez M, Mugueta C, Varo N, García de la Torre Á, Ruiz-Galdón M
Clin Chim Acta 2023 Aug 1;548:117471. Epub 2023 Jul 5 doi: 10.1016/j.cca.2023.117471. PMID: 37419300
Cacciaguerra L, Morris P, Tobin WO, Chen JJ, Banks SA, Elsbernd P, Redenbaugh V, Tillema JM, Montini F, Sechi E, Lopez-Chiriboga AS, Zalewski N, Guo Y, Rocca MA, Filippi M, Pittock SJ, Lucchinetti CF, Flanagan EP
Neurology 2023 Mar 28;100(13):e1418-e1432. Epub 2023 Jan 23 doi: 10.1212/WNL.0000000000206820. PMID: 36690455Free PMC Article
Hegen H, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):182-195. Epub 2022 Dec 17 doi: 10.1177/13524585221134217. PMID: 36527368Free PMC Article
Carta S, Ferraro D, Ferrari S, Briani C, Mariotto S
Crit Rev Clin Lab Sci 2022 Sep;59(6):391-404. Epub 2022 Mar 11 doi: 10.1080/10408363.2022.2039591. PMID: 35277112
Giovannoni G
Handb Clin Neurol 2014;122:681-702. doi: 10.1016/B978-0-444-52001-2.00029-7. PMID: 24507540

Clinical prediction guides

Zeng R, He L, Kuang Z, Jian Y, Qiu M, Liu Y, Hu M, Ye Y, Wu L
J Neuroimmunol 2024 Aug 15;393:578398. Epub 2024 Jun 20 doi: 10.1016/j.jneuroim.2024.578398. PMID: 39002186
Dekeyser C, Hautekeete M, Cambron M, Van Pesch V, Patti F, Kuhle J, Khoury S, Lechner Scott J, Gerlach O, Lugaresi A, Maimone D, Surcinelli A, Grammond P, Kalincik T, Habek M, Willekens B, Macdonell R, Lalive P, Csepany T, Butzkueven H, Boz C, Tomassini V, Foschi M, Sánchez-Menoyo JL, Altintas A, Mrabet S, Iuliano G, Sa MJ, Alroughani R, Karabudak R, Aguera-Morales E, Gray O, de Gans K, van der Walt A, McCombe PA, Deri N, Garber J, Al-Asmi A, Skibina O, Duquette P, Cartechini E, Spitaleri D, Gouider R, Soysal A, Van Hijfte L, Slee M, Amato MP, Buzzard K, Laureys G
J Neurol Neurosurg Psychiatry 2024 Oct 16;95(11):1021-1031. doi: 10.1136/jnnp-2023-333307. PMID: 38569872
Cacciaguerra L, Morris P, Tobin WO, Chen JJ, Banks SA, Elsbernd P, Redenbaugh V, Tillema JM, Montini F, Sechi E, Lopez-Chiriboga AS, Zalewski N, Guo Y, Rocca MA, Filippi M, Pittock SJ, Lucchinetti CF, Flanagan EP
Neurology 2023 Mar 28;100(13):e1418-e1432. Epub 2023 Jan 23 doi: 10.1212/WNL.0000000000206820. PMID: 36690455Free PMC Article
Hegen H, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):182-195. Epub 2022 Dec 17 doi: 10.1177/13524585221134217. PMID: 36527368Free PMC Article
Giovannoni G
Handb Clin Neurol 2014;122:681-702. doi: 10.1016/B978-0-444-52001-2.00029-7. PMID: 24507540

Recent systematic reviews

Hegen H, Walde J, Berek K, Arrambide G, Gnanapavan S, Kaplan B, Khalil M, Saadeh R, Teunissen C, Tumani H, Villar LM, Willrich MAV, Zetterberg H, Deisenhammer F
Mult Scler 2023 Feb;29(2):169-181. Epub 2022 Dec 1 doi: 10.1177/13524585221134213. PMID: 36453167Free PMC Article
Giannoccaro MP, Matteo E, Bartiromo F, Tonon C, Santorelli FM, Liguori R, Rizzo G
Neurol Sci 2022 Sep;43(9):5501-5511. Epub 2022 May 21 doi: 10.1007/s10072-022-06145-1. PMID: 35595875
Hegen H, Zinganell A, Auer M, Deisenhammer F
PLoS One 2019;14(4):e0215410. Epub 2019 Apr 15 doi: 10.1371/journal.pone.0215410. PMID: 30986255Free PMC Article
Jarius S, Haas J, Paul F, Wildemann B
J Neuroinflammation 2019 Feb 28;16(1):51. doi: 10.1186/s12974-019-1425-4. PMID: 30819213Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...