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Breast tumor luminal A or B

MedGen UID:
1052975
•Concept ID:
CN377721
•
Disease or Syndrome
Synonyms: breast tumor luminal; breast tumor luminal A or B; breast tumour luminal; luminal breast cancer; luminal breast carcinoma
 
Monarch Initiative: MONDO:0004990

Definition

Subsets of breast carcinoma defined by expression of genes characteristic of luminal epithelial cells. [from MONDO]

Professional guidelines

PubMed

Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
Hepatology 2023 Dec 1;78(6):1966-1986. Epub 2023 Jun 24 doi: 10.1097/HEP.0000000000000520. PMID: 37363821Free PMC Article
Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview.
Oliveira CB, Maher CG, Pinto RZ, Traeger AC, Lin CC, Chenot JF, van Tulder M, Koes BW
Eur Spine J 2018 Nov;27(11):2791-2803. Epub 2018 Jul 3 doi: 10.1007/s00586-018-5673-2. PMID: 29971708

Recent clinical studies

Etiology

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Established breast cancer risk factors and risk of intrinsic tumor subtypes.
Barnard ME, Boeke CE, Tamimi RM
Biochim Biophys Acta 2015 Aug;1856(1):73-85. Epub 2015 Jun 10 doi: 10.1016/j.bbcan.2015.06.002. PMID: 26071880
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS
J Clin Oncol 2009 Mar 10;27(8):1160-7. Epub 2009 Feb 9 doi: 10.1200/JCO.2008.18.1370. PMID: 19204204Free PMC Article
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lønning PE, Brown PO, Børresen-Dale AL, Botstein D
Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8418-23. Epub 2003 Jun 26 doi: 10.1073/pnas.0932692100. PMID: 12829800Free PMC Article

Diagnosis

Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR
Breast Cancer Res 2021 Jan 7;23(1):6. doi: 10.1186/s13058-020-01384-6. PMID: 33413533Free PMC Article
Molecular classification of breast cancer: what the pathologist needs to know.
Rakha EA, Green AR
Pathology 2017 Feb;49(2):111-119. Epub 2016 Dec 28 doi: 10.1016/j.pathol.2016.10.012. PMID: 28040199
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
Eroles P, Bosch A, Pérez-Fidalgo JA, Lluch A
Cancer Treat Rev 2012 Oct;38(6):698-707. Epub 2011 Dec 16 doi: 10.1016/j.ctrv.2011.11.005. PMID: 22178455
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS
J Clin Oncol 2009 Mar 10;27(8):1160-7. Epub 2009 Feb 9 doi: 10.1200/JCO.2008.18.1370. PMID: 19204204Free PMC Article

Therapy

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.
Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J; I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ
Cancer Cell 2022 Jun 13;40(6):609-623.e6. Epub 2022 May 26 doi: 10.1016/j.ccell.2022.05.005. PMID: 35623341Free PMC Article
Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.
Denkert C, von Minckwitz G, Darb-Esfahani S, Lederer B, Heppner BI, Weber KE, Budczies J, Huober J, Klauschen F, Furlanetto J, Schmitt WD, Blohmer JU, Karn T, Pfitzner BM, Kümmel S, Engels K, Schneeweiss A, Hartmann A, Noske A, Fasching PA, Jackisch C, van Mackelenbergh M, Sinn P, Schem C, Hanusch C, Untch M, Loibl S
Lancet Oncol 2018 Jan;19(1):40-50. Epub 2017 Dec 7 doi: 10.1016/S1470-2045(17)30904-X. PMID: 29233559
Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.
von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, Gerber B, Eiermann W, Hilfrich J, Huober J, Jackisch C, Kaufmann M, Konecny GE, Denkert C, Nekljudova V, Mehta K, Loibl S
J Clin Oncol 2012 May 20;30(15):1796-804. Epub 2012 Apr 16 doi: 10.1200/JCO.2011.38.8595. PMID: 22508812
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
Eroles P, Bosch A, Pérez-Fidalgo JA, Lluch A
Cancer Treat Rev 2012 Oct;38(6):698-707. Epub 2011 Dec 16 doi: 10.1016/j.ctrv.2011.11.005. PMID: 22178455
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA
J Clin Invest 2011 Jul;121(7):2750-67. doi: 10.1172/JCI45014. PMID: 21633166Free PMC Article

Prognosis

Prognosis of Tumor Microenvironment in Luminal B-Type Breast Cancer.
Lv J, Ren J, Zheng J, Zhang F, Han M
Dis Markers 2022;2022:5621441. Epub 2022 Feb 10 doi: 10.1155/2022/5621441. PMID: 35242245Free PMC Article
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
Breast cancer in men: a serie of 45 cases and literature review.
Methamem M, Ghadhab I, Hidar S, Briki R
Pan Afr Med J 2020;36:183. Epub 2020 Jul 14 doi: 10.11604/pamj.2020.36.183.22574. PMID: 32952827Free PMC Article
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Luminal A Breast Cancer and Molecular Assays: A Review.
Gao JJ, Swain SM
Oncologist 2018 May;23(5):556-565. Epub 2018 Feb 22 doi: 10.1634/theoncologist.2017-0535. PMID: 29472313Free PMC Article
Tumoral heterogeneity of breast cancer.
Roulot A, Héquet D, Guinebretière JM, Vincent-Salomon A, Lerebours F, Dubot C, Rouzier R
Ann Biol Clin (Paris) 2016 Dec 1;74(6):653-660. doi: 10.1684/abc.2016.1192. PMID: 27848916
Clinicopathological classification and traditional prognostic indicators of breast cancer.
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article

Recent systematic reviews

Intermittent Fasting in Breast Cancer: A Systematic Review and Critical Update of Available Studies.
Anemoulis M, Vlastos A, Kachtsidis V, Karras SN
Nutrients 2023 Jan 19;15(3) doi: 10.3390/nu15030532. PMID: 36771239Free PMC Article
Vitamin Supplementation and Dementia: A Systematic Review.
Gil Martínez V, Avedillo Salas A, Santander Ballestín S
Nutrients 2022 Feb 28;14(5) doi: 10.3390/nu14051033. PMID: 35268010Free PMC Article
Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JM
Nutrients 2021 Mar 12;13(3) doi: 10.3390/nu13030923. PMID: 33809274Free PMC Article
Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, Gronseth GS, Marson D, Pringsheim T, Day GS, Sager M, Stevens J, Rae-Grant A
Neurology 2018 Jan 16;90(3):126-135. Epub 2017 Dec 27 doi: 10.1212/WNL.0000000000004826. PMID: 29282327Free PMC Article
Acne and Nutrition: A Systematic Review.
Fiedler F, Stangl GI, Fiedler E, Taube KM
Acta Derm Venereol 2017 Jan 4;97(1):7-9. doi: 10.2340/00015555-2450. PMID: 27136757

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