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Splenic lipid-laden macrophage infiltration

MedGen UID:
1053390
•Concept ID:
CN376673
•
Finding
Synonyms: Spleen biopsy: lipid-laden macrophages; Splenic foamy cells
 
HPO: HP:6000160

Definition

Accumulation of foamy cells (lipid-laden macrophages) in the parenchyma of the spleen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic lipid-laden macrophage infiltration

Recent clinical studies

Etiology

Gaucheromas: When macrophages promote tumor formation and dissemination.
Ivanova M, Limgala RP, Changsila E, Kamath R, Ioanou C, Goker-Alpan O
Blood Cells Mol Dis 2018 Feb;68:100-105. Epub 2016 Oct 27 doi: 10.1016/j.bcmd.2016.10.018. PMID: 27839983

Therapy

Gaucheromas: When macrophages promote tumor formation and dissemination.
Ivanova M, Limgala RP, Changsila E, Kamath R, Ioanou C, Goker-Alpan O
Blood Cells Mol Dis 2018 Feb;68:100-105. Epub 2016 Oct 27 doi: 10.1016/j.bcmd.2016.10.018. PMID: 27839983
Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease.
Hollak CE, Evers L, Aerts JM, van Oers MH
Blood Cells Mol Dis 1997 Aug;23(2):201-12. doi: 10.1006/bcmd.1997.0137. PMID: 9236158
Massive omental reticuloendothelial cell lipid uptake in Tangier disease after splenectomy.
Schaefer EJ, Triche TJ, Zech LA, Stein LA, Kemeny MM, Brennan MF, Brewer HB Jr
Am J Med 1983 Sep;75(3):521-6. doi: 10.1016/0002-9343(83)90359-5. PMID: 6614036

Clinical prediction guides

Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease.
Hollak CE, Evers L, Aerts JM, van Oers MH
Blood Cells Mol Dis 1997 Aug;23(2):201-12. doi: 10.1006/bcmd.1997.0137. PMID: 9236158
Massive omental reticuloendothelial cell lipid uptake in Tangier disease after splenectomy.
Schaefer EJ, Triche TJ, Zech LA, Stein LA, Kemeny MM, Brennan MF, Brewer HB Jr
Am J Med 1983 Sep;75(3):521-6. doi: 10.1016/0002-9343(83)90359-5. PMID: 6614036

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