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Increased myocardial pyrophosphate uptake

MedGen UID:
1053579
•Concept ID:
CN376579
•
Finding
HPO: HP:6000067

Definition

Amount of pyrophosphate uptake by the myocardium as demonstrated by by technetium pyrophosphate (99mTc-PYP) scintigraphy above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased myocardial pyrophosphate uptake

Professional guidelines

PubMed

Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment.
Bell D, Jackson M, Nicoll JJ, Millar A, Dawes J, Muir AL
Br Heart J 1990 Feb;63(2):82-7. doi: 10.1136/hrt.63.2.82. PMID: 2317413Free PMC Article

Recent clinical studies

Etiology

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
Non-cardiac uptake of technetium-99m pyrophosphate in transthyretin cardiac amyloidosis.
Sperry BW, Gonzalez MH, Brunken R, Cerqueira MD, Hanna M, Jaber WA
J Nucl Cardiol 2019 Oct;26(5):1630-1637. Epub 2018 Jan 17 doi: 10.1007/s12350-017-1166-7. PMID: 29344917
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Diagnosis and prognosis of right ventricular infarction.
Rodrigues EA, Dewhurst NG, Smart LM, Hannan WJ, Muir AL
Br Heart J 1986 Jul;56(1):19-26. doi: 10.1136/hrt.56.1.19. PMID: 3015175Free PMC Article
Measurement of myocardial infarct size by technetium pyrophosphate single-photon tomography.
Corbett JR, Lewis SE, Wolfe CL, Jansen DE, Lewis M, Rellas JS, Parkey RW, Rude RE, Buja LM, Willerson JT
Am J Cardiol 1984 Dec 1;54(10):1231-6. doi: 10.1016/s0002-9149(84)80072-7. PMID: 6095634

Diagnosis

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
Non-cardiac uptake of technetium-99m pyrophosphate in transthyretin cardiac amyloidosis.
Sperry BW, Gonzalez MH, Brunken R, Cerqueira MD, Hanna M, Jaber WA
J Nucl Cardiol 2019 Oct;26(5):1630-1637. Epub 2018 Jan 17 doi: 10.1007/s12350-017-1166-7. PMID: 29344917
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Measurement of myocardial infarct size by technetium pyrophosphate single-photon tomography.
Corbett JR, Lewis SE, Wolfe CL, Jansen DE, Lewis M, Rellas JS, Parkey RW, Rude RE, Buja LM, Willerson JT
Am J Cardiol 1984 Dec 1;54(10):1231-6. doi: 10.1016/s0002-9149(84)80072-7. PMID: 6095634
Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis.
Wizenberg TA, Muz J, Sohn YH, Samlowski W, Weissler AM
Am Heart J 1982 Apr;103(4 Pt 1):468-73. doi: 10.1016/0002-8703(82)90331-3. PMID: 6278906

Therapy

Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Cold infarction areas of varying size in the presence of left ventricular dysfunction: the impact on left ventricular ejection fraction determination by gated SPECT compared to radionuclide ventriculography.
Canbaz F, Basoglu T, Semirgin SU, Yapici O, Yazici M
Hell J Nucl Med 2005 Sep-Dec;8(3):149-53. PMID: 16390019
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis.
Ganné F, Vasse M, Beaudeux JL, Peynet J, François A, Mishal Z, Chartier A, Tobelem G, Vannier JP, Soria J, Soria C
Thromb Haemost 2000 Oct;84(4):680-8. PMID: 11057870
Implications of delayed image on simultaneous thallium-201/technetium-99m pyrophosphate dual emission computed tomography early after acute myocardial infarction.
Sakata K, Yoshida H, Ono N, Ohtani S, Mori N, Yokoyama S, Hoshino T, Kaburagi T, Kurata C
Jpn Circ J 1993 Jan;57(1):27-36. doi: 10.1253/jcj.57.27. PMID: 8437339

Prognosis

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
A challenging road to diagnosing transthyretin cardiac amyloidosis and using technetium-99m pyrophosphate bone scintigraphy in nuclear cardiology - A case report.
Kavita A, Abdul Onny MA, Suppiah S, Abdul Aziz AF, Hashim H, Raja Shariff RE, Ng CS
Med J Malaysia 2021 Sep;76(5):762-767. PMID: 34508392
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Clinical significance of early myocardial 99mTc-pyrophosphate uptake in patients with acute myocardial infarction.
Kondo M, Takahashi M, Matsuda T, Kume N, Yuzuki Y, Shimono Y, Fujiwara H
Am Heart J 1987 Feb;113(2 Pt 1):250-6. doi: 10.1016/0002-8703(87)90261-4. PMID: 3028113

Clinical prediction guides

Deep Learning-Enabled Quantification of (99m)Tc-Pyrophosphate SPECT/CT for Cardiac Amyloidosis.
Miller RJH, Shanbhag A, Michalowska AM, Kavanagh P, Liang JX, Builoff V, Fine NM, Dey D, Berman DS, Slomka PJ
J Nucl Med 2024 Jul 1;65(7):1144-1150. doi: 10.2967/jnumed.124.267542. PMID: 38724278Free PMC Article
Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.
Sperry BW, Vranian MN, Tower-Rader A, Hachamovitch R, Hanna M, Brunken R, Phelan D, Cerqueira MD, Jaber WA
JACC Cardiovasc Imaging 2018 Feb;11(2 Pt 1):234-242. Epub 2017 Oct 5 doi: 10.1016/j.jcmg.2017.06.020. PMID: 28917675
Relevance of 99mTc-MIBI rest uptake, ejection fraction and location of contractile abnormality in predicting myocardial recovery after revascularization.
González JM, Castell-Conesa J, Candell-Riera J, Rosselló-Urgell J; Spanish Working Group of Nuclear Cardiology
Nucl Med Commun 2001 Jul;22(7):795-805. doi: 10.1097/00006231-200107000-00011. PMID: 11453053
Clinical significance of early myocardial 99mTc-pyrophosphate uptake in patients with acute myocardial infarction.
Kondo M, Takahashi M, Matsuda T, Kume N, Yuzuki Y, Shimono Y, Fujiwara H
Am Heart J 1987 Feb;113(2 Pt 1):250-6. doi: 10.1016/0002-8703(87)90261-4. PMID: 3028113
Accuracy of localization of acute myocardial infarction by 12 lead electrocardiography.
Yasuda T, Ribeiro LG, Holman BL, Alpert JS, Maroko PR
J Electrocardiol 1982 Apr;15(2):181-8. doi: 10.1016/s0022-0736(82)80014-9. PMID: 6279750

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