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Elevated circulating Angiotensin-converting enzyme concentration

MedGen UID:
1053639
•Concept ID:
CN376726
•
Finding
Synonym: Angiotensin-converting enzyme (ACE) high in blood
 
HPO: HP:6000213

Definition

Concentration of angiotensin-converting enzyme (ACE) in the blood circulation above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating Angiotensin-converting enzyme concentration

Professional guidelines

PubMed

Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction.
Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B
J Renin Angiotensin Aldosterone Syst 2015 Jun;16(2):422-7. Epub 2014 Aug 25 doi: 10.1177/1470320314539181. PMID: 25155623
Influence of angiotensin converting enzyme (ACE) genotype on interpretation of diagnostic tests for serum ACE activity.
Stokes GS, Monaghan JC, Schrader AP, Glenn CL, Ryan M, Morris BJ
Aust N Z J Med 1999 Jun;29(3):315-8. doi: 10.1111/j.1445-5994.1999.tb00713.x. PMID: 10868493
The circulating renin-angiotensin system during treatment with metoprolol or captopril in patients with heart failure due to non-ischaemic dilated cardiomyopathy.
Jansson K, Dahlström U, Karlberg BE, Karlsson E, Nylander E, Nyquist O, Karlberg KE
J Intern Med 1999 May;245(5):435-43. doi: 10.1046/j.1365-2796.1999.00458.x. PMID: 10363743

Recent clinical studies

Therapy

Circulating Plasma Concentrations of ACE2 in Primary Aldosteronism and Cardiovascular Outcomes.
Wu VC, Peng KY, Hu YH, Chang CC, Chan CK, Lai TS, Lin YH, Wang SM, Lu CC, Liu YC, Tsai YC, Chueh JS
J Clin Endocrinol Metab 2022 Nov 25;107(12):3242-3251. doi: 10.1210/clinem/dgac539. PMID: 36125178Free PMC Article
Elevated Angiotensin 1-7/Angiotensin II Ratio Predicts Favorable Outcomes in Patients With Heart Failure.
Wang K, Basu R, Poglitsch M, Bakal JA, Oudit GY
Circ Heart Fail 2020 Jul;13(7):e006939. Epub 2020 Jun 25 doi: 10.1161/CIRCHEARTFAILURE.120.006939. PMID: 32580658
Adrenomedullin and heart failure.
Rademaker MT, Cameron VA, Charles CJ, Lainchbury JG, Nicholls MG, Richards AM
Regul Pept 2003 Apr 15;112(1-3):51-60. doi: 10.1016/s0167-0115(03)00022-3. PMID: 12667625
Recruitable ACE and tissue repair in the infarcted heart.
Weber KT, Sun Y
J Renin Angiotensin Aldosterone Syst 2000 Dec;1(4):295-303. doi: 10.3317/jraas.2000.058. PMID: 11967815
The role of the renin-angiotensin and natriuretic peptide systems in the pulmonary vasculature.
Cargill RI, Lipworth BJ
Br J Clin Pharmacol 1995 Jul;40(1):11-8. doi: 10.1111/j.1365-2125.1995.tb04528.x. PMID: 8527262Free PMC Article

Prognosis

Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19.
Benedetti S, Sisti D, Vandini D, Barocci S, Sudano M, Carlotti E, Teng JLL, Zamai L
Adv Biol Regul 2023 Aug;89:100973. Epub 2023 May 23 doi: 10.1016/j.jbior.2023.100973. PMID: 37257289Free PMC Article
Elevated Angiotensin 1-7/Angiotensin II Ratio Predicts Favorable Outcomes in Patients With Heart Failure.
Wang K, Basu R, Poglitsch M, Bakal JA, Oudit GY
Circ Heart Fail 2020 Jul;13(7):e006939. Epub 2020 Jun 25 doi: 10.1161/CIRCHEARTFAILURE.120.006939. PMID: 32580658
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors.
Sama IE, Ravera A, Santema BT, van Goor H, Ter Maaten JM, Cleland JGF, Rienstra M, Friedrich AW, Samani NJ, Ng LL, Dickstein K, Lang CC, Filippatos G, Anker SD, Ponikowski P, Metra M, van Veldhuisen DJ, Voors AA
Eur Heart J 2020 May 14;41(19):1810-1817. doi: 10.1093/eurheartj/ehaa373. PMID: 32388565Free PMC Article
Adrenomedullin and heart failure.
Rademaker MT, Cameron VA, Charles CJ, Lainchbury JG, Nicholls MG, Richards AM
Regul Pept 2003 Apr 15;112(1-3):51-60. doi: 10.1016/s0167-0115(03)00022-3. PMID: 12667625
Hyperfiltration and diabetic nephropathy: is it the beginning? Or is it the end?
Castellino P, Shohat J, DeFronzo RA
Semin Nephrol 1990 May;10(3):228-41. PMID: 2190280

Clinical prediction guides

Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19.
Benedetti S, Sisti D, Vandini D, Barocci S, Sudano M, Carlotti E, Teng JLL, Zamai L
Adv Biol Regul 2023 Aug;89:100973. Epub 2023 May 23 doi: 10.1016/j.jbior.2023.100973. PMID: 37257289Free PMC Article
An ACE2-Based Decoy Inhibitor Effectively Neutralizes SARS-CoV-2 Omicron BA.5 Variant.
Zhang H, Hu B, Lv P, Liu Y, Guo M, Wu Z, Zhou K, Dai M, Yu X, Liu Z, Yu B, Xu L, Guo M, Cai K, Li Y
Viruses 2022 Oct 28;14(11) doi: 10.3390/v14112387. PMID: 36366484Free PMC Article
Circulating Plasma Concentrations of ACE2 in Primary Aldosteronism and Cardiovascular Outcomes.
Wu VC, Peng KY, Hu YH, Chang CC, Chan CK, Lai TS, Lin YH, Wang SM, Lu CC, Liu YC, Tsai YC, Chueh JS
J Clin Endocrinol Metab 2022 Nov 25;107(12):3242-3251. doi: 10.1210/clinem/dgac539. PMID: 36125178Free PMC Article
Elevated Angiotensin 1-7/Angiotensin II Ratio Predicts Favorable Outcomes in Patients With Heart Failure.
Wang K, Basu R, Poglitsch M, Bakal JA, Oudit GY
Circ Heart Fail 2020 Jul;13(7):e006939. Epub 2020 Jun 25 doi: 10.1161/CIRCHEARTFAILURE.120.006939. PMID: 32580658
Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction.
Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B
J Renin Angiotensin Aldosterone Syst 2015 Jun;16(2):422-7. Epub 2014 Aug 25 doi: 10.1177/1470320314539181. PMID: 25155623

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