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Bone marrow edema

MedGen UID:
1054544
•Concept ID:
CN378269
•
Finding
HPO: HP:6000917

Definition

Accumulation of excess fluid in the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow edema

Professional guidelines

PubMed

MRI in axial spondyloarthritis: understanding an 'ASAS-positive MRI' and the ASAS classification criteria.
Diekhoff T, Lambert R, Hermann KG
Skeletal Radiol 2022 Sep;51(9):1721-1730. Epub 2022 Feb 23 doi: 10.1007/s00256-022-04018-4. PMID: 35199195Free PMC Article
Bone Marrow Edema: Overview of Etiology and Treatment Strategies.
Tarantino U, Greggi C, Cariati I, Caldora P, Capanna R, Capone A, Civinini R, Colagrande S, De Biase P, Falez F, Iolascon G, Maraghelli D, Masi L, Cerinic MM, Sessa G, Brandi ML
J Bone Joint Surg Am 2022 Jan 19;104(2):189-200. doi: 10.2106/JBJS.21.00300. PMID: 34780382
Bone Marrow Edema, Clinical Significance, and Treatment Options: A Review.
Akhavan S, Martinkovich SC, Kasik C, DeMeo PJ
J Am Acad Orthop Surg 2020 Oct 15;28(20):e888-e899. doi: 10.5435/JAAOS-D-20-00142. PMID: 32701688

Recent clinical studies

Etiology

Foot and Ankle Bone Marrow Edema Assessment in Long Distance Runners.
Hatch R, Devito P, Reams M, Pena F
Foot Ankle Int 2023 Dec;44(12):1231-1238. Epub 2023 Nov 23 doi: 10.1177/10711007231201332. PMID: 37994648
Subchondral insufficiency fracture of the knee: review of current concepts and radiological differential diagnoses.
Ochi J, Nozaki T, Nimura A, Yamaguchi T, Kitamura N
Jpn J Radiol 2022 May;40(5):443-457. Epub 2021 Nov 29 doi: 10.1007/s11604-021-01224-3. PMID: 34843043Free PMC Article
Recent Updates in Juvenile Spondyloarthritis.
Srinivasalu H, Sikora KA, Colbert RA
Rheum Dis Clin North Am 2021 Nov;47(4):565-583. Epub 2021 Aug 21 doi: 10.1016/j.rdc.2021.07.001. PMID: 34635292Free PMC Article
Multimodality imaging of subacromial impingement syndrome.
Pesquer L, Borghol S, Meyer P, Ropars M, Dallaudière B, Abadie P
Skeletal Radiol 2018 Jul;47(7):923-937. Epub 2018 Feb 14 doi: 10.1007/s00256-018-2875-y. PMID: 29445933
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes.
Li G, Yin J, Gao J, Cheng TS, Pavlos NJ, Zhang C, Zheng MH
Arthritis Res Ther 2013;15(6):223. doi: 10.1186/ar4405. PMID: 24321104Free PMC Article

Diagnosis

Bone Marrow Edema: pathogenetic features.
Molfetta L, Florian A, Saviola G, Frediani B
Clin Ter 2022 Sep-Oct;173(5):434-439. doi: 10.7417/CT.2022.2459. PMID: 36155729
MRI in axial spondyloarthritis: understanding an 'ASAS-positive MRI' and the ASAS classification criteria.
Diekhoff T, Lambert R, Hermann KG
Skeletal Radiol 2022 Sep;51(9):1721-1730. Epub 2022 Feb 23 doi: 10.1007/s00256-022-04018-4. PMID: 35199195Free PMC Article
Subchondral insufficiency fracture of the knee: review of current concepts and radiological differential diagnoses.
Ochi J, Nozaki T, Nimura A, Yamaguchi T, Kitamura N
Jpn J Radiol 2022 May;40(5):443-457. Epub 2021 Nov 29 doi: 10.1007/s11604-021-01224-3. PMID: 34843043Free PMC Article
Bone Marrow Edema: Overview of Etiology and Treatment Strategies.
Tarantino U, Greggi C, Cariati I, Caldora P, Capanna R, Capone A, Civinini R, Colagrande S, De Biase P, Falez F, Iolascon G, Maraghelli D, Masi L, Cerinic MM, Sessa G, Brandi ML
J Bone Joint Surg Am 2022 Jan 19;104(2):189-200. doi: 10.2106/JBJS.21.00300. PMID: 34780382
Bone Marrow Edema, Clinical Significance, and Treatment Options: A Review.
Akhavan S, Martinkovich SC, Kasik C, DeMeo PJ
J Am Acad Orthop Surg 2020 Oct 15;28(20):e888-e899. doi: 10.5435/JAAOS-D-20-00142. PMID: 32701688

Therapy

Diagnostic and therapeutic practices in adult chronic nonbacterial osteomyelitis (CNO).
Leerling AT, Clunie G, Koutrouba E, Dekkers OM, Appelman-Dijkstra NM, Winter EM
Orphanet J Rare Dis 2023 Jul 21;18(1):206. doi: 10.1186/s13023-023-02831-1. PMID: 37480122Free PMC Article
Vertebroplasty versus Active Control Intervention for Chronic Osteoporotic Vertebral Compression Fractures: The VERTOS V Randomized Controlled Trial.
Carli D, Venmans A, Lodder P, Donga E, van Oudheusden T, Boukrab I, Schoemaker K, Smeets A, Schonenberg C, Hirsch J, de Vries J, Lohle P
Radiology 2023 Jul;308(1):e222535. doi: 10.1148/radiol.222535. PMID: 37462495
Research Advances in the Treatment of Bone Marrow Edema Syndrome.
Li S, Yu H, Long S, Li J, He Y, Zheng X, Yang S, Tang Y, Xie Q, Zheng W
J Clin Densitom 2023 Apr-Jun;26(2):101367. Epub 2023 Mar 18 doi: 10.1016/j.jocd.2023.03.006. PMID: 37005106
Bone Marrow Edema, Clinical Significance, and Treatment Options: A Review.
Akhavan S, Martinkovich SC, Kasik C, DeMeo PJ
J Am Acad Orthop Surg 2020 Oct 15;28(20):e888-e899. doi: 10.5435/JAAOS-D-20-00142. PMID: 32701688
The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis.
Chang C, Greenspan A, Gershwin ME
J Autoimmun 2020 Jun;110:102460. Epub 2020 Apr 16 doi: 10.1016/j.jaut.2020.102460. PMID: 32307211

Prognosis

Wrist Injuries in Climbers.
Schöffl V, von Schroeder H, Lisse J, El-Sheikh Y, Küpper T, Klinder A, Lutter C
Am J Sports Med 2023 Nov;51(13):3416-3425. Epub 2023 Oct 6 doi: 10.1177/03635465231199671. PMID: 37800447
The role of imaging in osteoarthritis.
Park EH, Fritz J
Best Pract Res Clin Rheumatol 2023 Jun;37(2):101866. Epub 2023 Aug 31 doi: 10.1016/j.berh.2023.101866. PMID: 37659890
Emerging Quantitative Imaging Techniques in Sports Medicine.
Hayashi D, Roemer FW, Tol JL, Heiss R, Crema MD, Jarraya M, Rossi I, Luna A, Guermazi A
Radiology 2023 Aug;308(2):e221531. doi: 10.1148/radiol.221531. PMID: 37552087
Bone Marrow Edema, Clinical Significance, and Treatment Options: A Review.
Akhavan S, Martinkovich SC, Kasik C, DeMeo PJ
J Am Acad Orthop Surg 2020 Oct 15;28(20):e888-e899. doi: 10.5435/JAAOS-D-20-00142. PMID: 32701688
Stress fractures in athletes.
Fredericson M, Jennings F, Beaulieu C, Matheson GO
Top Magn Reson Imaging 2006 Oct;17(5):309-25. doi: 10.1097/RMR.0b013e3180421c8c. PMID: 17414993

Clinical prediction guides

Foot and Ankle Bone Marrow Edema Assessment in Long Distance Runners.
Hatch R, Devito P, Reams M, Pena F
Foot Ankle Int 2023 Dec;44(12):1231-1238. Epub 2023 Nov 23 doi: 10.1177/10711007231201332. PMID: 37994648
Two-year imaging outcomes from a phase 3 randomized trial of secukinumab in patients with non-radiographic axial spondyloarthritis.
Braun J, Blanco R, Marzo-Ortega H, Gensler LS, Van den Bosch F, Hall S, Kameda H, Poddubnyy D, van de Sande M, van der Heijde D, Zhuang T, Stefanska A, Readie A, Richards HB, Deodhar A
Arthritis Res Ther 2023 May 16;25(1):80. doi: 10.1186/s13075-023-03051-5. PMID: 37194094Free PMC Article
Subchondroplasty for Osteonecrosis of the Knee.
Fitzpatrick BR, Hasanspahic B, Kuechle JB
Orthopedics 2023 Sep-Oct;46(5):e287-e290. Epub 2023 Mar 15 doi: 10.3928/01477447-20230310-03. PMID: 36921231
Osteonecrosis of the Knee: Not all Bone Edema is the Same.
Pearl MC, Mont MA, Scuderi GR
Orthop Clin North Am 2022 Oct;53(4):377-392. Epub 2022 Sep 14 doi: 10.1016/j.ocl.2022.06.002. PMID: 36208881
A clinical overview of bone marrow edema.
Manara M, Varenna M
Reumatismo 2014 Jul 28;66(2):184-96. doi: 10.4081/reumatismo.2014.790. PMID: 25069499

Recent systematic reviews

Diagnostic accuracy of dual-energy CT for bone marrow edema in patients with acute knee injury: a systematic review and meta-analysis.
Li Z, Chen X, Fang H, Li C, Shi L, Fan X, Xu X, Gao F, Sun W, Qing J
J Orthop Surg Res 2023 Nov 2;18(1):826. doi: 10.1186/s13018-023-04151-3. PMID: 37919746Free PMC Article
Asymptomatic Bone Marrow Edema in Weight-bearing Bones in Athletes and Military Trainees: A Systematic Literature Review.
Karimi A, El-Abtah M, Sinkler M, Faraji N, Voos J, Harlow E, Miskovsky S
Int J Sports Med 2023 Sep;44(10):683-691. Epub 2023 Jun 1 doi: 10.1055/a-2013-2226. PMID: 37263276
Comparison of various treatment modalities for the management of bone marrow edema syndrome/transient osteoporosis in men and non-pregnant women: a systematic review.
Paraskevopoulos K, Keskinis A, Vasios IS, Makiev KG, Tilkeridis K, Drosos GI, Ververidis AN
Osteoporos Int 2023 Feb;34(2):269-290. Epub 2022 Nov 12 doi: 10.1007/s00198-022-06584-8. PMID: 36370218
Bone Marrow Edema: pathogenetic features.
Molfetta L, Florian A, Saviola G, Frediani B
Clin Ter 2022 Sep-Oct;173(5):434-439. doi: 10.7417/CT.2022.2459. PMID: 36155729
Chondrosarcomas of the hands and feet: A case series and systematic review of the literature.
Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572

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