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Anti-recoverin antibody positivity

MedGen UID:
1054876
•Concept ID:
CN378028
•
Finding
Synonym: Anti-retinal CAR antigen antibody
 
HPO: HP:6000882

Definition

The presence of autoantibodies in the serum that react against recoverin. Recoverins are calcium-binding proteins primarily expressed in retinal rod photoreceptors and primarily involved in phototransduction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-recoverin antibody positivity

Recent clinical studies

Therapy

Anti-recoverin antibody positive Heidenhain variant CJD: a case report.
Chung CT, Jao T, Su JJ
Prion 2023 Dec;17(1):133-137. doi: 10.1080/19336896.2023.2223527. PMID: 37337645Free PMC Article
Autoimmune retinopathy with positive anti-recoverin antibodies not associated with neoplasms: Case report.
Oporto Caroca JI, Oporto Caroca J
Arch Soc Esp Oftalmol (Engl Ed) 2019 Nov;94(11):540-544. Epub 2019 Aug 27 doi: 10.1016/j.oftal.2019.07.015. PMID: 31470998

Prognosis

Anti-recoverin antibody positive Heidenhain variant CJD: a case report.
Chung CT, Jao T, Su JJ
Prion 2023 Dec;17(1):133-137. doi: 10.1080/19336896.2023.2223527. PMID: 37337645Free PMC Article
Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy.
Kobayashi M, Ikezoe T, Uemura Y, Takeuchi T, Ueno H, Ohtsuki Y, Taguchi H
Lung Cancer 2007 Jun;56(3):319-26. Epub 2007 Mar 19 doi: 10.1016/j.lungcan.2007.01.030. PMID: 17374419
Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramer.
Rong S, Ikeda H, Sato Y, Hirohashi Y, Takamura Y, Sahara H, Sato T, Maeda A, Ohguro H, Sato N
Cancer Immunol Immunother 2002 Jul;51(5):282-90. Epub 2002 Apr 24 doi: 10.1007/s00262-002-0282-6. PMID: 12070715Free PMC Article

Clinical prediction guides

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus.
Li M, Cheng G, Wang Z, Liu W, Jin Y, Huang B, Wang Y, Qu J, Shi G, Su Y, He J, Li Z
Lupus 2020 Oct;29(11):1346-1352. Epub 2020 Jul 23 doi: 10.1177/0961203320940780. PMID: 32703115
Autoimmune retinopathy with positive anti-recoverin antibodies not associated with neoplasms: Case report.
Oporto Caroca JI, Oporto Caroca J
Arch Soc Esp Oftalmol (Engl Ed) 2019 Nov;94(11):540-544. Epub 2019 Aug 27 doi: 10.1016/j.oftal.2019.07.015. PMID: 31470998
Antigen-specificity of antiretinal antibodies in patients with noninfectious uveitis.
Gibbs E, Matsubara J, Cao S, Cui J, Forooghian F
Can J Ophthalmol 2017 Oct;52(5):463-467. Epub 2017 May 10 doi: 10.1016/j.jcjo.2017.03.010. PMID: 28985805
Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramer.
Rong S, Ikeda H, Sato Y, Hirohashi Y, Takamura Y, Sahara H, Sato T, Maeda A, Ohguro H, Sato N
Cancer Immunol Immunother 2002 Jul;51(5):282-90. Epub 2002 Apr 24 doi: 10.1007/s00262-002-0282-6. PMID: 12070715Free PMC Article
Recoverin immunoreactivity in mammalian cone bipolar cells.
Milam AH, Dacey DM, Dizhoor AM
Vis Neurosci 1993 Jan-Feb;10(1):1-12. doi: 10.1017/s0952523800003175. PMID: 8424920

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