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Composite lymphoma

MedGen UID:
107468
Concept ID:
C0545080
Neoplastic Process
Synonyms: Composite Lymphoma; Composite Lymphomas; Lymphoma, Composite; Lymphomas, Composite
SNOMED CT: Composite Hodgkin and non-Hodgkin lymphoma (128798004); Composite Hodgkin and non-Hodgkin lymphoma (1156403002); Composite lymphoma (1156403002)
 
Monarch Initiative: MONDO:0005710
Orphanet: ORPHA168966

Definition

A rare lymphoma with concurrent occurrence of two or more histologic types of lymphoma involving the same anatomic site. Composite lymphomas can be combinations of two non-Hodgkin lymphomas or of a non-Hodgkin and a Hodgkin lymphoma. In many cases, the neoplasms are clonally related. Clinical presentation and treatment are determined by the more aggressive component. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComposite lymphoma

Professional guidelines

PubMed

Campanelli M, Cabry F, Marasca R, Gelmini R
Minerva Chir 2019 Jun;74(3):218-223. Epub 2018 Oct 9 doi: 10.23736/S0026-4733.18.07752-0. PMID: 30306770
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047

Recent clinical studies

Etiology

Vasudevan JA, Nair RA, Sukumaran R, Nair SG
Indian J Cancer 2017 Jan-Mar;54(1):358-361. doi: 10.4103/ijc.IJC_89_17. PMID: 29199722
Suefuji N, Niino D, Arakawa F, Karube K, Kimura Y, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Ichikawa A, Sugita Y, Ohshima K
Pathol Int 2012 Oct;62(10):690-8. doi: 10.1111/j.1440-1827.2012.02858.x. PMID: 23005596
Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G
Histopathology 2001 Apr;38(4):285-306. doi: 10.1046/j.1365-2559.2001.01120.x. PMID: 11318894
Tezcan H, Vose JM, Bast M, Bierman PJ, Kessinger A, Armitage JO
Leuk Lymphoma 1999 Jul;34(3-4):273-85. doi: 10.3109/10428199909050952. PMID: 10439364
Jaffe ES, Zarate-Osorno A, Kingma DW, Raffeld M, Medeiros LJ
Ann Oncol 1994;5 Suppl 1:7-11. doi: 10.1093/annonc/5.suppl_1.s7. PMID: 8172822

Diagnosis

Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047
Papathomas TG, Venizelos I, Dunphy CH, Said JW, Wang ML, Campo E, Swerdlow SH, Chan JC, Bueso-Ramos CE, Weisenburger DD, Medeiros LJ, Young KH
Hum Pathol 2012 Apr;43(4):467-80. Epub 2012 Jan 4 doi: 10.1016/j.humpath.2011.08.024. PMID: 22221705
Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G
Histopathology 2001 Apr;38(4):285-306. doi: 10.1046/j.1365-2559.2001.01120.x. PMID: 11318894
Kim H, Hendrickson R, Dorfman RF
Cancer 1977 Sep;40(3):959-76. doi: 10.1002/1097-0142(197709)40:3<959::aid-cncr2820400302>3.0.co;2-3. PMID: 332325

Therapy

Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Hwang YY, Loong F, Chung LP, Chim CS
Diagn Pathol 2011 Jul 8;6:63. doi: 10.1186/1746-1596-6-63. PMID: 21736761Free PMC Article
Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L
Diagn Pathol 2011 Jul 6;6:60. doi: 10.1186/1746-1596-6-60. PMID: 21733146Free PMC Article
Tezcan H, Vose JM, Bast M, Bierman PJ, Kessinger A, Armitage JO
Leuk Lymphoma 1999 Jul;34(3-4):273-85. doi: 10.3109/10428199909050952. PMID: 10439364
Toner GC, Sinclair RA, Sutherland RC, Schwarz MA
Am J Clin Pathol 1986 Sep;86(3):375-8. doi: 10.1093/ajcp/86.3.375. PMID: 3755861

Prognosis

Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047
Wang HW, Yang W, Wang L, Lu YL, Lu JY
World J Gastroenterol 2013 Oct 7;19(37):6304-9. doi: 10.3748/wjg.v19.i37.6304. PMID: 24115832Free PMC Article
Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G
Histopathology 2001 Apr;38(4):285-306. doi: 10.1046/j.1365-2559.2001.01120.x. PMID: 11318894
Kim H, Hendrickson R, Dorfman RF
Cancer 1977 Sep;40(3):959-76. doi: 10.1002/1097-0142(197709)40:3<959::aid-cncr2820400302>3.0.co;2-3. PMID: 332325

Clinical prediction guides

Tao Y, Chen H, Liu D, Dai X
Leuk Res 2021 Dec;111:106669. Epub 2021 Jul 16 doi: 10.1016/j.leukres.2021.106669. PMID: 34333276
Goyal G, Nguyen AH, Kendric K, Caponetti GC
Pathol Res Pract 2016 Dec;212(12):1179-1190. Epub 2016 Nov 5 doi: 10.1016/j.prp.2016.11.002. PMID: 27887763
Eberle FC, Salaverria I, Steidl C, Summers TA Jr, Pittaluga S, Neriah SB, Rodriguez-Canales J, Xi L, Ylaya K, Liewehr D, Dunleavy K, Wilson WH, Hewitt SM, Raffeld M, Gascoyne RD, Siebert R, Jaffe ES
Mod Pathol 2011 Dec;24(12):1586-97. Epub 2011 Aug 5 doi: 10.1038/modpathol.2011.116. PMID: 21822207Free PMC Article
Zettl A, Rüdiger T, Marx A, Müller-Hermelink HK, Ott G
Histopathology 2005 Feb;46(2):217-28. doi: 10.1111/j.1365-2559.2005.02046.x. PMID: 15693895
Jaffe ES, Zarate-Osorno A, Kingma DW, Raffeld M, Medeiros LJ
Ann Oncol 1994;5 Suppl 1:7-11. doi: 10.1093/annonc/5.suppl_1.s7. PMID: 8172822

Recent systematic reviews

Ahmed A, Aragao AP, Mudaliar K, Wilcox R, Vardiman J, Anastasi J, Mirza K
Am J Dermatopathol 2019 Oct;41(10):757-766. doi: 10.1097/DAD.0000000000001424. PMID: 30973519

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