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Cerebral neuroblastoma

MedGen UID:
107851
•Concept ID:
C0559458
•
Neoplastic Process
Synonyms: Central Nervous System Neuroblastoma; central nervous system neuroblastoma; Cerebral Hemispheric Neuroblastoma; cerebral hemispheric neuroblastoma; Cerebral Neuroblastoma; cerebral neuroblastoma; Cerebral Neuroblastoma, PNET; cerebral neuroblastoma, PNET; Neuroblastoma of brain; neuroblastoma of brain; Neuroblastoma of Cerebral Hemispheres; neuroblastoma of cerebral hemispheres; Neuroblastoma of Cerebrum; neuroblastoma of cerebrum; neuroblastoma of telencephalon; neuroblastoma of the cerebral hemisphere; Neuroblastoma of the Cerebral Hemispheres; neuroblastoma of the cerebral hemispheres; Neuroblastoma of the Cerebrum; neuroblastoma of the cerebrum; telencephalon neuroblastoma
SNOMED CT: Neuroblastoma of brain (281560004)
 
Monarch Initiative: MONDO:0002900

Definition

A neuroblastoma arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral neuroblastoma

Professional guidelines

PubMed

Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
Kovnar EH, Kellie SJ, Horowitz ME, Sanford RA, Langston JW, Mulhern RK, Jenkins JJ, Douglass EC, Etcubanas EE, Fairclough DL
J Clin Oncol 1990 Feb;8(2):330-6. doi: 10.1200/JCO.1990.8.2.330. PMID: 2153766
Primary cerebral neuroblastoma. Long-term follow-up review and therapeutic guidelines.
Berger MS, Edwards MS, Wara WM, Levin VA, Wilson CB
J Neurosurg 1983 Sep;59(3):418-23. doi: 10.3171/jns.1983.59.3.0418. PMID: 6886755

Recent clinical studies

Etiology

High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system.
Gill P, Litzow M, Buckner J, Arndt C, Moynihan T, Christianson T, Ansell S, Galanis E
Cancer 2008 Apr 15;112(8):1805-11. doi: 10.1002/cncr.23362. PMID: 18300237
Primary cerebral neuroblastoma: a case treated with adjuvant chemotherapy and radiotherapy.
Yariş N, Yavuz MN, Reis A, Yavuz AA, Okten A
Turk J Pediatr 2004 Apr-Jun;46(2):182-5. PMID: 15214753
Effective chemotherapy for advanced CNS embryonal tumors in adults.
Galanis E, Buckner JC, Schomberg PJ, Hammack JE, Raffel C, Scheithauer BW
J Clin Oncol 1997 Aug;15(8):2939-44. doi: 10.1200/JCO.1997.15.8.2939. PMID: 9256138
Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
Kovnar EH, Kellie SJ, Horowitz ME, Sanford RA, Langston JW, Mulhern RK, Jenkins JJ, Douglass EC, Etcubanas EE, Fairclough DL
J Clin Oncol 1990 Feb;8(2):330-6. doi: 10.1200/JCO.1990.8.2.330. PMID: 2153766
Primary cerebral neuroblastoma. Long-term follow-up review and therapeutic guidelines.
Berger MS, Edwards MS, Wara WM, Levin VA, Wilson CB
J Neurosurg 1983 Sep;59(3):418-23. doi: 10.3171/jns.1983.59.3.0418. PMID: 6886755

Diagnosis

Primitive neuroectodermal tumors, embryonal tumors, and other small cell and poorly differentiated malignant neoplasms of the central and peripheral nervous systems.
Vogel H, Fuller GN
Ann Diagn Pathol 2003 Dec;7(6):387-98. doi: 10.1016/j.anndiagpath.2003.09.007. PMID: 15018124
Glioneuronal tumors of the central nervous system.
McLendon RE, Provenzale J
Brain Tumor Pathol 2002;19(2):51-8. doi: 10.1007/BF02478927. PMID: 12622133
Malignant supratentorial glial-neuronal neoplasms: report of two cases and review of the literature.
McLendon RE, Bentley RC, Parisi JE, Tien RD, Harrison JC, Tarbell NJ, Billitt AL, Gualtieri RJ, Friedman HS
Arch Pathol Lab Med 1997 May;121(5):485-92. PMID: 9167602
Ultrastructural characterization of oligodendroglial-like cells in central nervous system tumors.
Cenacchi G, Giangaspero F, Cerasoli S, Manetto V, Martinelli GN
Ultrastruct Pathol 1996 Nov-Dec;20(6):537-47. doi: 10.3109/01913129609016358. PMID: 8940761
Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
Kovnar EH, Kellie SJ, Horowitz ME, Sanford RA, Langston JW, Mulhern RK, Jenkins JJ, Douglass EC, Etcubanas EE, Fairclough DL
J Clin Oncol 1990 Feb;8(2):330-6. doi: 10.1200/JCO.1990.8.2.330. PMID: 2153766

Therapy

Concurrent Chemoradiotherapy as an Adjuvant Treatment of Primary Central Nervous System Neuroblastoma.
Amor RB, Bohli M, Naimi Z, Yahyaoui J, Kochbati L
Perm J 2022 Jun 29;26(2):166-171. Epub 2022 Jun 17 doi: 10.7812/TPP/21.147. PMID: 35933664Free PMC Article
High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system.
Gill P, Litzow M, Buckner J, Arndt C, Moynihan T, Christianson T, Ansell S, Galanis E
Cancer 2008 Apr 15;112(8):1805-11. doi: 10.1002/cncr.23362. PMID: 18300237
Effective chemotherapy for advanced CNS embryonal tumors in adults.
Galanis E, Buckner JC, Schomberg PJ, Hammack JE, Raffel C, Scheithauer BW
J Clin Oncol 1997 Aug;15(8):2939-44. doi: 10.1200/JCO.1997.15.8.2939. PMID: 9256138
Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
Kovnar EH, Kellie SJ, Horowitz ME, Sanford RA, Langston JW, Mulhern RK, Jenkins JJ, Douglass EC, Etcubanas EE, Fairclough DL
J Clin Oncol 1990 Feb;8(2):330-6. doi: 10.1200/JCO.1990.8.2.330. PMID: 2153766

Prognosis

Primary cerebral neuroblastoma: a case treated with adjuvant chemotherapy and radiotherapy.
Yariş N, Yavuz MN, Reis A, Yavuz AA, Okten A
Turk J Pediatr 2004 Apr-Jun;46(2):182-5. PMID: 15214753
Histopathological variants of central neurocytoma: Report of 10 cases.
Favereaux A, Vital A, Loiseau H, Dousset V, Caille J, Petry K
Ann Pathol 2000 Dec;20(6):558-63. PMID: 11148351
Effective chemotherapy for advanced CNS embryonal tumors in adults.
Galanis E, Buckner JC, Schomberg PJ, Hammack JE, Raffel C, Scheithauer BW
J Clin Oncol 1997 Aug;15(8):2939-44. doi: 10.1200/JCO.1997.15.8.2939. PMID: 9256138
Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
Kovnar EH, Kellie SJ, Horowitz ME, Sanford RA, Langston JW, Mulhern RK, Jenkins JJ, Douglass EC, Etcubanas EE, Fairclough DL
J Clin Oncol 1990 Feb;8(2):330-6. doi: 10.1200/JCO.1990.8.2.330. PMID: 2153766
Primary cerebral neuroblastoma. Long-term follow-up review and therapeutic guidelines.
Berger MS, Edwards MS, Wara WM, Levin VA, Wilson CB
J Neurosurg 1983 Sep;59(3):418-23. doi: 10.3171/jns.1983.59.3.0418. PMID: 6886755

Clinical prediction guides

Comparative immunohistochemical study of insulin-like growth factor II and insulin-like growth factor receptor type 1 in pediatric brain tumors.
Ogino S, Kubo S, Abdul-Karim FW, Cohen ML
Pediatr Dev Pathol 2001 Jan-Feb;4(1):23-31. doi: 10.1007/s100240010112. PMID: 11200487
Effective chemotherapy for advanced CNS embryonal tumors in adults.
Galanis E, Buckner JC, Schomberg PJ, Hammack JE, Raffel C, Scheithauer BW
J Clin Oncol 1997 Aug;15(8):2939-44. doi: 10.1200/JCO.1997.15.8.2939. PMID: 9256138
Ultrastructural characterization of oligodendroglial-like cells in central nervous system tumors.
Cenacchi G, Giangaspero F, Cerasoli S, Manetto V, Martinelli GN
Ultrastruct Pathol 1996 Nov-Dec;20(6):537-47. doi: 10.3109/01913129609016358. PMID: 8940761
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102
Primary cerebral neuroblastoma. A clinicopathological study of 35 cases.
Horten BC, Rubinstein LJ
Brain 1976 Dec;99(4):735-56. doi: 10.1093/brain/99.4.735. PMID: 1030655

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