U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Old-aged sensorineural hearing impairment

MedGen UID:
10911
•Concept ID:
C0033074
•
Pathologic Function
Synonyms: Age-related hearing impairment; Presbycusis
SNOMED CT: Age-related hearing loss (49526009); Presbycusis (49526009); Senile deafness (49526009); Presbyacusia (49526009)
 
HPO: HP:0040113
Monarch Initiative: MONDO:0043765

Definition

Bilateral hearing loss caused by progressive degeneration of cochlear structures and central auditory pathways, typically associated with the aging process. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOld-aged sensorineural hearing impairment

Conditions with this feature

Autosomal dominant nonsyndromic hearing loss 31
MedGen UID:
325209
•Concept ID:
C1837617
•
Disease or Syndrome
An autosomal dominant nonsyndromic deafness that has material basis in variation in the chromosome region 6p21.3.
See: Condition Record
Autosomal dominant nonsyndromic hearing loss 31

Professional guidelines

PubMed

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Presbycusis and its management.
Ko J
Br J Nurs 2010 Feb 11-24;19(3):160-5. doi: 10.12968/bjon.2010.19.3.46536. PMID: 20220659

Recent clinical studies

Etiology

The Effects of Age-Related Hearing Loss on the Brain and Cognitive Function.
Slade K, Plack CJ, Nuttall HE
Trends Neurosci 2020 Oct;43(10):810-821. Epub 2020 Aug 19 doi: 10.1016/j.tins.2020.07.005. PMID: 32826080
Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes.
Jafari Z, Kolb BE, Mohajerani MH
Ageing Res Rev 2019 Dec;56:100963. Epub 2019 Sep 23 doi: 10.1016/j.arr.2019.100963. PMID: 31557539
Age-related Hearing Loss and Dementia.
Chern A, Golub JS
Alzheimer Dis Assoc Disord 2019 Jul-Sep;33(3):285-290. doi: 10.1097/WAD.0000000000000325. PMID: 31335455Free PMC Article
Age-Related Hearing Loss.
Bowl MR, Dawson SJ
Cold Spring Harb Perspect Med 2019 Aug 1;9(8) doi: 10.1101/cshperspect.a033217. PMID: 30291149Free PMC Article
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article

Diagnosis

Age-Related Hearing Loss.
Lin FR
N Engl J Med 2024 Apr 25;390(16):1505-1512. doi: 10.1056/NEJMcp2306778. PMID: 38657246
Inner ear disorders.
Fík Z, Bouček J
Cas Lek Cesk 2019 Winter;158(6):216-220. PMID: 31931577
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline.
Rutherford BR, Brewster K, Golub JS, Kim AH, Roose SP
Am J Psychiatry 2018 Mar 1;175(3):215-224. Epub 2017 Dec 5 doi: 10.1176/appi.ajp.2017.17040423. PMID: 29202654Free PMC Article
Presbycusis.
Gates GA, Mills JH
Lancet 2005 Sep 24-30;366(9491):1111-20. doi: 10.1016/S0140-6736(05)67423-5. PMID: 16182900
Mitochondrial deafness.
Fischel-Ghodsian N
Ear Hear 2003 Aug;24(4):303-13. doi: 10.1097/01.AUD.0000079802.82344.B5. PMID: 12923421

Therapy

Geriatric sudden deafness.
Zhang BY, Young YH
Am J Otolaryngol 2021 Jul-Aug;42(4):102985. Epub 2021 Feb 16 doi: 10.1016/j.amjoto.2021.102985. PMID: 33610920
Age-related Hearing Loss and Dementia.
Chern A, Golub JS
Alzheimer Dis Assoc Disord 2019 Jul-Sep;33(3):285-290. doi: 10.1097/WAD.0000000000000325. PMID: 31335455Free PMC Article
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline.
Rutherford BR, Brewster K, Golub JS, Kim AH, Roose SP
Am J Psychiatry 2018 Mar 1;175(3):215-224. Epub 2017 Dec 5 doi: 10.1176/appi.ajp.2017.17040423. PMID: 29202654Free PMC Article
Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy.
Watson N, Ding B, Zhu X, Frisina RD
Ageing Res Rev 2017 Nov;40:142-148. Epub 2017 Oct 7 doi: 10.1016/j.arr.2017.10.002. PMID: 29017893Free PMC Article

Prognosis

Cochlear metabolomics, highlighting novel insights of purine metabolic alterations in age-related hearing loss.
Wan H, Wang W, Liu J, Zhang Y, Yang B, Hua R, Chen H, Chen S, Hua Q
Hear Res 2023 Dec;440:108913. Epub 2023 Nov 4 doi: 10.1016/j.heares.2023.108913. PMID: 37939412
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Boucher S, Tai FWJ, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C
Proc Natl Acad Sci U S A 2020 Dec 8;117(49):31278-31289. Epub 2020 Nov 23 doi: 10.1073/pnas.2010782117. PMID: 33229591Free PMC Article
Cross-modal plasticity in developmental and age-related hearing loss: Clinical implications.
Glick H, Sharma A
Hear Res 2017 Jan;343:191-201. Epub 2016 Sep 6 doi: 10.1016/j.heares.2016.08.012. PMID: 27613397Free PMC Article
Challenges and opportunities in presbycusis.
Parham K, McKinnon BJ, Eibling D, Gates GA
Otolaryngol Head Neck Surg 2011 Apr;144(4):491-5. Epub 2011 Feb 10 doi: 10.1177/0194599810395079. PMID: 21493222
Immune-mediated inner ear disease.
Bovo R, Aimoni C, Martini A
Acta Otolaryngol 2006 Oct;126(10):1012-21. doi: 10.1080/00016480600606723. PMID: 16923703

Clinical prediction guides

Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Boucher S, Tai FWJ, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C
Proc Natl Acad Sci U S A 2020 Dec 8;117(49):31278-31289. Epub 2020 Nov 23 doi: 10.1073/pnas.2010782117. PMID: 33229591Free PMC Article
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Non-implantable Artificial Hearing Technology.
Lu L, Zhang X, Gao X
Adv Exp Med Biol 2019;1130:145-163. doi: 10.1007/978-981-13-6123-4_9. PMID: 30915706
Hearing impairment and retirement.
Fischer ME, Cruickshanks KJ, Pinto A, Klein BE, Klein R, Dalton DS
J Am Acad Audiol 2014 Feb;25(2):164-70. doi: 10.3766/jaaa.25.2.5. PMID: 24828217Free PMC Article
Challenges and opportunities in presbycusis.
Parham K, McKinnon BJ, Eibling D, Gates GA
Otolaryngol Head Neck Surg 2011 Apr;144(4):491-5. Epub 2011 Feb 10 doi: 10.1177/0194599810395079. PMID: 21493222

Recent systematic reviews

Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta-Analysis.
Shih MC, Gordis TM, Lambert PR, Nguyen SA, Meyer TA
Laryngoscope 2023 May;133(5):1025-1035. Epub 2022 Sep 10 doi: 10.1002/lary.30384. PMID: 36087028
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article
Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults.
Schilder AG, Chong LY, Ftouh S, Burton MJ
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD012665. doi: 10.1002/14651858.CD012665.pub2. PMID: 29256573Free PMC Article
Auditory deprivation and health in the elderly.
Cherko M, Hickson L, Bhutta M
Maturitas 2016 Jun;88:52-7. Epub 2016 Mar 14 doi: 10.1016/j.maturitas.2016.03.008. PMID: 27105698
Determinants of hearing-aid adoption and use among the elderly: a systematic review.
Ng JH, Loke AY
Int J Audiol 2015 May;54(5):291-300. Epub 2015 Feb 2 doi: 10.3109/14992027.2014.966922. PMID: 25640403

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...