U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subacute combined degeneration of spinal cord

MedGen UID:
113144
•Concept ID:
C0221065
•
Disease or Syndrome
Synonyms: Neuropathy, Subacute Combined Degeneration; Subacute Combined Degeneration; Subacute Combined Neuropathy Degeneration
SNOMED CT: Subacute combined degeneration of spinal cord (60576007); Posterolateral sclerosis (60576007); Vitamin B>12< deficiency disease of spinal cord (60576007); Putnam-Dana syndrome (60576007); Lichtheim's disease (60576007); Subacute combined degeneration (60576007); Neuromyelopathy due to vitamin B12 deficiency (60576007); SACD - Subacute combined degeneration (60576007); Vitamin B>12< deficiency neuropathy (60576007)

Definition

A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubacute combined degeneration of spinal cord

Professional guidelines

PubMed

Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment.
Paris A, Lake L, Joseph A, Workman A, Walton J, Hayton T, Evangelou N, Lilleker JB, Ayling RM, Nicholl D, Noyce AJ
Pract Neurol 2023 Jun;23(3):222-228. Epub 2023 Feb 22 doi: 10.1136/pn-2022-003631. PMID: 36813556Free PMC Article
Tumors masquerading as neurological diseases: A caution for clinicians in planning diagnosis and treatment.
Vidhya Annapoorni CS, Retnaswami CS, Mailankody P, Katragadda P, Pillai SK, Rangarajan A, Padmanabha H, Pendharkar H
Neurol India 2020 Mar-Apr;68(2):368-372. doi: 10.4103/0028-3886.280647. PMID: 32415012
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360

Recent clinical studies

Etiology

Subacute combined degeneration of the spinal cord concurrent with acute pulmonary embolism: a case report.
Pang X, Hao Y, Ma L, Zhuo L, Liu L, Feng J
J Int Med Res 2021 May;49(5):3000605211016815. doi: 10.1177/03000605211016815. PMID: 34057834Free PMC Article

Diagnosis

Autoimmune polyglandular syndrome type II presenting as subacute combined degeneration of spinal cord: a neuroendocrinology crossroad.
Bapat P, Kushwaha S, Gupta C, Kirangowda R, Seth V
Rom J Intern Med 2022 Jun 1;60(2):123-126. Epub 2022 Jun 14 doi: 10.2478/rjim-2021-0038. PMID: 34958534
Subacute combined degeneration of the spinal cord concurrent with acute pulmonary embolism: a case report.
Pang X, Hao Y, Ma L, Zhuo L, Liu L, Feng J
J Int Med Res 2021 May;49(5):3000605211016815. doi: 10.1177/03000605211016815. PMID: 34057834Free PMC Article
Skin pigmentation in a patient with vitamin B12 deficiency presented with subacute combined degeneration of spinal cord.
Sarwar AK, Zafar MU, Rehman Abid Butt MU
J Pak Med Assoc 2020 Jan;70(1):174-177. doi: 10.5455/JPMA.23581. PMID: 31954048
Rapid healing of a patient with dramatic subacute combined degeneration of spinal cord: a case report.
Roessler FC, Wolff S
BMC Res Notes 2017 Jan 3;10(1):18. doi: 10.1186/s13104-016-2344-4. PMID: 28057043Free PMC Article
MRI in subacute combined degeneration of spinal cord: a case report and review of literature.
Srikanth SG, Jayakumar PN, Vasudev MK, Taly AB, Chandrashekar HS
Neurol India 2002 Sep;50(3):310-2. PMID: 12391459

Therapy

Unusual case of subacute combined degeneration of spinal cord.
Riley CJ
Br Med J 1966 Sep 3;2(5513):566. doi: 10.1136/bmj.2.5513.566. PMID: 5917368Free PMC Article

Prognosis

Autoimmune polyglandular syndrome type II presenting as subacute combined degeneration of spinal cord: a neuroendocrinology crossroad.
Bapat P, Kushwaha S, Gupta C, Kirangowda R, Seth V
Rom J Intern Med 2022 Jun 1;60(2):123-126. Epub 2022 Jun 14 doi: 10.2478/rjim-2021-0038. PMID: 34958534

Clinical prediction guides

Myelopathy during treatment of autoimmune hemolytic anaemia.
Murthy GL, Srinivasan VR, Kaul S, Gayathri K
J Assoc Physicians India 2002 Aug;50:1075-6. PMID: 12421037

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...