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Necrolytic migratory erythema

MedGen UID:
113156
•Concept ID:
C0221243
•
Disease or Syndrome
Synonyms: Erythema, Necrolytic Migratory; Erythemas, Necrolytic Migratory; Migratory Erythema, Necrolytic; Migratory Erythemas, Necrolytic; Necrolytic Migratory Erythema; Necrolytic Migratory Erythemas
SNOMED CT: Necrolytic migratory erythema (15576007)
 
HPO: HP:0031181

Definition

Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrolytic migratory erythema

Professional guidelines

PubMed

Characteristics and treatment options of glucagonomas: a national study from the French Group of Endocrine Tumors and ENDOCAN-RENATEN network.
Perrier M, Brugel M, Gérard L, Goichot B, Lièvre A, Lepage C, Hautefeuille V, Do Cao C, Smith D, Thuillier P, Cros J, Cadiot G, Walter T, de Mestier L
Eur J Endocrinol 2023 Dec 6;189(6):575-583. doi: 10.1093/ejendo/lvad157. PMID: 38039101
Glucagonoma syndrome: a review and update on treatment.
John AM, Schwartz RA
J Eur Acad Dermatol Venereol 2016 Dec;30(12):2016-2022. Epub 2016 Jul 16 doi: 10.1111/jdv.13752. PMID: 27422767
Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology, and treatment.
Hendricks WM
Semin Dermatol 1991 Dec;10(4):282-92. PMID: 1764355

Recent clinical studies

Etiology

Third reported case of rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-En-Y gastric bypass: case report and literature review.
Salaheldin Y, El Ansari W, Aljaloudi E, Elhag W
Eat Weight Disord 2022 Apr;27(3):1235-1241. Epub 2021 Jun 1 doi: 10.1007/s40519-021-01154-z. PMID: 34061321Free PMC Article
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Cutaneous manifestations of gastrointestinal disease: part I.
Shah KR, Boland CR, Patel M, Thrash B, Menter A
J Am Acad Dermatol 2013 Feb;68(2):189.e1-21; quiz 210. doi: 10.1016/j.jaad.2012.10.037. PMID: 23317980
Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity?
Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M
Int J Dermatol 2005 Nov;44(11):916-21. doi: 10.1111/j.1365-4632.2004.02232.x. PMID: 16336523

Diagnosis

Skin manifestations of pancreatic diseases.
Kunovsky L, Dite P, Brezinova E, Sedlakova L, Trna J, Jabandziev P
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2022 Dec;166(4):353-358. Epub 2022 Jul 22 doi: 10.5507/bp.2022.035. PMID: 35938387
VISUAL VIGNETTE.
Maurelli M, Gisondi P, Girolomoni G
Endocr Pract 2020 Feb;26(2):253. Epub 2019 Jun 6 doi: 10.4158/EP-2019-0158. PMID: 31170359
Visual Vignette.
Sathyakumar S, Cherian KE, Jebasingh F, Hepzhibah J, Kapoor N, Paul TV
Endocr Pract 2017 Jan;23(1):116. Epub 2016 Sep 15 doi: 10.4158/EP161307.VV. PMID: 27631840
Intertriginous eruption.
Wolf R, Oumeish OY, Parish LC
Clin Dermatol 2011 Mar-Apr;29(2):173-9. doi: 10.1016/j.clindermatol.2010.09.009. PMID: 21396557
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412

Therapy

A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Nutrition and bullous skin diseases.
Fedeles F, Murphy M, Rothe MJ, Grant-Kels JM
Clin Dermatol 2010 Nov-Dec;28(6):627-43. doi: 10.1016/j.clindermatol.2010.03.036. PMID: 21034987
Necrolytic acral erythema: a review of the literature.
Geria AN, Holcomb KZ, Scheinfeld NS
Cutis 2009 Jun;83(6):309-14. PMID: 19681342
Necrolytic acral erythema: response to combination therapy with interferon and ribavirin.
Hivnor CM, Yan AC, Junkins-Hopkins JM, Honig PJ
J Am Acad Dermatol 2004 May;50(5 Suppl):S121-4. doi: 10.1016/j.jaad.2003.09.017. PMID: 15097946
Iatrogenic necrolytic migratory erythema: a case report and review of nonglucagonoma-associated necrolytic migratory erythema.
Mullans EA, Cohen PR
J Am Acad Dermatol 1998 May;38(5 Pt 2):866-73. doi: 10.1016/s0190-9622(98)70478-5. PMID: 9591806

Prognosis

A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Current knowledge in inflammatory dermatopathology.
Fung MA, Barr KL
Dermatol Clin 2012 Oct;30(4):667-84, vii. Epub 2012 Jul 28 doi: 10.1016/j.det.2012.06.004. PMID: 23021053
Is necrolytic migratory erythema due to glucagonoma a misnomer? A more apt name might be mucosal and intertriginous erosive dermatitis.
Grewal P, Salopek TG
J Cutan Med Surg 2012 Mar-Apr;16(2):76-82. doi: 10.2310/7750.2011.10134. PMID: 22513058
Nutrition and bullous skin diseases.
Fedeles F, Murphy M, Rothe MJ, Grant-Kels JM
Clin Dermatol 2010 Nov-Dec;28(6):627-43. doi: 10.1016/j.clindermatol.2010.03.036. PMID: 21034987
Necrolytic migratory erythema: case report and clinical review.
Adam DN, Cohen PD, Ghazarian D
J Cutan Med Surg 2003 Jul-Aug;7(4):333-8. doi: 10.1007/s10227-002-0127-0. PMID: 14738101

Clinical prediction guides

Autophagy in malnutrition-associated dermatoses.
Hirai Y, Miyake T, Hamada T, Yamasaki O, Morizane S, Mori T, Iwatsuki K
J Dermatol 2019 Jan;46(1):43-47. Epub 2018 Oct 31 doi: 10.1111/1346-8138.14694. PMID: 30379352
Intertriginous eruption.
Wolf R, Oumeish OY, Parish LC
Clin Dermatol 2011 Mar-Apr;29(2):173-9. doi: 10.1016/j.clindermatol.2010.09.009. PMID: 21396557
Necrolytic migratory erythema.
Kovács RK, Korom I, Dobozy A, Farkas G, Ormos J, Kemény L
J Cutan Pathol 2006 Mar;33(3):242-5. doi: 10.1111/j.0303-6987.2006.00408.x. PMID: 16466513
Etiology and pathogenesis of necrolytic migratory erythema: review of the literature.
Tierney EP, Badger J
MedGenMed 2004 Sep 10;6(3):4. PMID: 15520626Free PMC Article
Iatrogenic necrolytic migratory erythema: a case report and review of nonglucagonoma-associated necrolytic migratory erythema.
Mullans EA, Cohen PR
J Am Acad Dermatol 1998 May;38(5 Pt 2):866-73. doi: 10.1016/s0190-9622(98)70478-5. PMID: 9591806

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