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Macropsia

MedGen UID:
115934
•Concept ID:
C0233771
•
Finding
Synonym: Macropsias
SNOMED CT: Macropsia (422120000)

Definition

An alteration in visual perception that causes objects to appear larger than their actual size. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacropsia

Professional guidelines

PubMed

The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy.
Bartalena L, Kahaly GJ, Baldeschi L, Dayan CM, Eckstein A, Marcocci C, Marinò M, Vaidya B, Wiersinga WM; EUGOGO †
Eur J Endocrinol 2021 Aug 27;185(4):G43-G67. doi: 10.1530/EJE-21-0479. PMID: 34297684
Diagnosis and treatment of idiopathic intracranial hypertension.
Raoof N, Hoffmann J
Cephalalgia 2021 Apr;41(4):472-478. Epub 2021 Feb 25 doi: 10.1177/0333102421997093. PMID: 33631966Free PMC Article
Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580

Recent clinical studies

Etiology

Spectral-Domain Optical Coherence Tomography Findings in Patients With Macropsia.
Jeon S, Jung B, Lee WK
Ophthalmic Surg Lasers Imaging Retina 2018 Sep 1;49(9):656-663. doi: 10.3928/23258160-20180831-02. PMID: 30222799
Aniseikonia in various retinal disorders.
Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
Graefes Arch Clin Exp Ophthalmol 2017 Jun;255(6):1063-1071. Epub 2017 Jan 25 doi: 10.1007/s00417-017-3597-x. PMID: 28124146
Relationship Between Vertical and Horizontal Aniseikonia Scores and Vertical and Horizontal OCT Images in Idiopathic Epiretinal Membrane.
Chung H, Son G, Hwang DJ, Lee K, Park Y, Sohn J
Invest Ophthalmol Vis Sci 2015 Oct;56(11):6542-8. doi: 10.1167/iovs.15-16874. PMID: 26451682
"Alice in wonderland" syndrome: presenting and follow-up characteristics.
Liu AM, Liu JG, Liu GW, Liu GT
Pediatr Neurol 2014 Sep;51(3):317-20. Epub 2014 Apr 12 doi: 10.1016/j.pediatrneurol.2014.04.007. PMID: 25160537
Retinally induced aniseikonia: a case series.
Rutstein RP
Optom Vis Sci 2012 Nov;89(11):e50-5. doi: 10.1097/OPX.0b013e31826c5e06. PMID: 23069723

Diagnosis

Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion.
Morikawa S, Okamoto F, Murakami T, Sugiura Y, Hiraoka T, Oshika T
Jpn J Ophthalmol 2021 Sep;65(5):672-679. Epub 2021 Jul 12 doi: 10.1007/s10384-021-00852-6. PMID: 34250549
Spectral-Domain Optical Coherence Tomography Findings in Patients With Macropsia.
Jeon S, Jung B, Lee WK
Ophthalmic Surg Lasers Imaging Retina 2018 Sep 1;49(9):656-663. doi: 10.3928/23258160-20180831-02. PMID: 30222799
The Alice-in-Wonderland Syndrome.
Lanska DJ, Lanska JR
Front Neurol Neurosci 2018;42:142-150. Epub 2017 Nov 17 doi: 10.1159/000475722. PMID: 29151098
Aniseikonia in various retinal disorders.
Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
Graefes Arch Clin Exp Ophthalmol 2017 Jun;255(6):1063-1071. Epub 2017 Jan 25 doi: 10.1007/s00417-017-3597-x. PMID: 28124146
Metamorphopsia: An Overlooked Visual Symptom.
Midena E, Vujosevic S
Ophthalmic Res 2015;55(1):26-36. Epub 2015 Nov 11 doi: 10.1159/000441033. PMID: 26554918

Therapy

Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion.
Morikawa S, Okamoto F, Murakami T, Sugiura Y, Hiraoka T, Oshika T
Jpn J Ophthalmol 2021 Sep;65(5):672-679. Epub 2021 Jul 12 doi: 10.1007/s10384-021-00852-6. PMID: 34250549
Comparative analysis of metamorphopsia and aniseikonia after vitrectomy for epiretinal membrane, macular hole, or rhegmatogenous retinal detachment.
Fukuyama H, Ishikawa H, Komuku Y, Araki T, Kimura N, Gomi F
PLoS One 2020;15(5):e0232758. Epub 2020 May 8 doi: 10.1371/journal.pone.0232758. PMID: 32384099Free PMC Article
Alice in Wonderland syndrome as aura of migraine.
Ilik F, Ilik K
Neurocase 2014 Aug;20(4):474-5. Epub 2013 Aug 19 doi: 10.1080/13554794.2013.826676. PMID: 23957288
POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection.
Engelsen BA, Tzoulis C, Karlsen B, Lillebø A, Laegreid LM, Aasly J, Zeviani M, Bindoff LA
Brain 2008 Mar;131(Pt 3):818-28. Epub 2008 Jan 30 doi: 10.1093/brain/awn007. PMID: 18238797
Horizontal and vertical micropsia following macula-off rhegmatogenous retinal-detachment surgical repair.
Ugarte M, Williamson TH
Graefes Arch Clin Exp Ophthalmol 2006 Nov;244(11):1545-8. Epub 2006 Mar 17 doi: 10.1007/s00417-006-0290-x. PMID: 16544113

Prognosis

Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion.
Morikawa S, Okamoto F, Murakami T, Sugiura Y, Hiraoka T, Oshika T
Jpn J Ophthalmol 2021 Sep;65(5):672-679. Epub 2021 Jul 12 doi: 10.1007/s10384-021-00852-6. PMID: 34250549
Aniseikonia in various retinal disorders.
Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
Graefes Arch Clin Exp Ophthalmol 2017 Jun;255(6):1063-1071. Epub 2017 Jan 25 doi: 10.1007/s00417-017-3597-x. PMID: 28124146
"Alice in wonderland" syndrome: presenting and follow-up characteristics.
Liu AM, Liu JG, Liu GW, Liu GT
Pediatr Neurol 2014 Sep;51(3):317-20. Epub 2014 Apr 12 doi: 10.1016/j.pediatrneurol.2014.04.007. PMID: 25160537
Retinally induced aniseikonia: a case series.
Rutstein RP
Optom Vis Sci 2012 Nov;89(11):e50-5. doi: 10.1097/OPX.0b013e31826c5e06. PMID: 23069723
POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection.
Engelsen BA, Tzoulis C, Karlsen B, Lillebø A, Laegreid LM, Aasly J, Zeviani M, Bindoff LA
Brain 2008 Mar;131(Pt 3):818-28. Epub 2008 Jan 30 doi: 10.1093/brain/awn007. PMID: 18238797

Clinical prediction guides

Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion.
Morikawa S, Okamoto F, Murakami T, Sugiura Y, Hiraoka T, Oshika T
Jpn J Ophthalmol 2021 Sep;65(5):672-679. Epub 2021 Jul 12 doi: 10.1007/s10384-021-00852-6. PMID: 34250549
Comparative analysis of metamorphopsia and aniseikonia after vitrectomy for epiretinal membrane, macular hole, or rhegmatogenous retinal detachment.
Fukuyama H, Ishikawa H, Komuku Y, Araki T, Kimura N, Gomi F
PLoS One 2020;15(5):e0232758. Epub 2020 May 8 doi: 10.1371/journal.pone.0232758. PMID: 32384099Free PMC Article
Changes in aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
Murakami T, Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
Sci Rep 2019 Aug 12;9(1):11588. doi: 10.1038/s41598-019-48112-5. PMID: 31406166Free PMC Article
Aniseikonia in various retinal disorders.
Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
Graefes Arch Clin Exp Ophthalmol 2017 Jun;255(6):1063-1071. Epub 2017 Jan 25 doi: 10.1007/s00417-017-3597-x. PMID: 28124146
Relationship Between Vertical and Horizontal Aniseikonia Scores and Vertical and Horizontal OCT Images in Idiopathic Epiretinal Membrane.
Chung H, Son G, Hwang DJ, Lee K, Park Y, Sohn J
Invest Ophthalmol Vis Sci 2015 Oct;56(11):6542-8. doi: 10.1167/iovs.15-16874. PMID: 26451682

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