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Synesthesia(SYNSTH)

MedGen UID:
115936
Concept ID:
C0233778
Mental or Behavioral Dysfunction
Synonym: SYNSTH
SNOMED CT: Synesthesia (8488006)
 
HPO: HP:6000024
OMIM®: 612759

Definition

Synesthesia is broadly defined as the experience of involuntary sensory crossactivation in which the presentation of a particular stimulus elicits a secondary sensory-perceptual experience (Barnett et al., 2008). Although this phenomenon can be acquired or transient due to trauma or drugs, there is a congenital or developmental form that shows familial patterns. Synesthesia can occur between any 2 sensory modalities, but the most common and best-studied forms of synesthesia involve the association of color with linguistic stimuli such as letters, numbers, or words, or with music ('colored hearing,' 'colored music'; Baron-Cohen et al., 1996). Other less common forms include the induction of tastes by words, the induction of touch by vision, the induction of shapes by tastes, and the personification of numbers (Barnett et al., 2008). [from OMIM]

Recent clinical studies

Etiology

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Arend I, Yuen K, Ashkenazi S, Henik A
Neuropsychologia 2022 Feb 10;166:108155. Epub 2022 Jan 10 doi: 10.1016/j.neuropsychologia.2022.108155. PMID: 35016889
Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF
Proc Natl Acad Sci U S A 2020 May 5;117(18):10089-10096. Epub 2020 Apr 22 doi: 10.1073/pnas.1914668117. PMID: 32321833Free PMC Article
Rinaldi LJ, Smees R, Carmichael DA, Simner J
Cortex 2020 May;126:141-152. Epub 2020 Jan 28 doi: 10.1016/j.cortex.2020.01.007. PMID: 32078819
Berman B, Serper M
J Nerv Ment Dis 2016 Aug;204(8):614-9. doi: 10.1097/NMD.0000000000000532. PMID: 27218222

Diagnosis

van Leeuwen TM, Wilsson L, Norrman HN, Dingemanse M, Bölte S, Neufeld J
Cortex 2021 Dec;145:236-249. Epub 2021 Oct 15 doi: 10.1016/j.cortex.2021.09.016. PMID: 34763130
Rinaldi LJ, Smees R, Carmichael DA, Simner J
Front Biosci (Elite Ed) 2020 Mar 1;12(1):162-182. doi: 10.2741/E865. PMID: 32114456
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Stone J, Vermeulen M
Handb Clin Neurol 2016;139:271-281. doi: 10.1016/B978-0-12-801772-2.00024-2. PMID: 27719847
Lacey S, Martinez M, McCormick K, Sathian K
Eur J Neurosci 2016 Nov;44(9):2716-2721. Epub 2016 Sep 15 doi: 10.1111/ejn.13381. PMID: 27564319Free PMC Article

Therapy

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Spence C
Cogn Res Princ Implic 2020 Oct 28;5(1):52. doi: 10.1186/s41235-020-00246-1. PMID: 33113051Free PMC Article
Rinaldi LJ, Smees R, Carmichael DA, Simner J
Front Biosci (Elite Ed) 2020 Mar 1;12(1):162-182. doi: 10.2741/E865. PMID: 32114456
Schwartzman DJ, Bor D, Rothen N, Seth AK
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190030. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0030. PMID: 31630656Free PMC Article
Liechti ME
Neuropsychopharmacology 2017 Oct;42(11):2114-2127. Epub 2017 Apr 27 doi: 10.1038/npp.2017.86. PMID: 28447622Free PMC Article

Prognosis

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Stone J, Vermeulen M
Handb Clin Neurol 2016;139:271-281. doi: 10.1016/B978-0-12-801772-2.00024-2. PMID: 27719847
Ward J
Cogn Neurosci 2015;6(2-3):45-7. doi: 10.1080/17588928.2015.1055238. PMID: 26274902
Safran AB, Sanda N
Curr Opin Neurol 2015 Feb;28(1):36-44. doi: 10.1097/WCO.0000000000000169. PMID: 25545055Free PMC Article

Clinical prediction guides

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Liechti ME
Neuropsychopharmacology 2017 Oct;42(11):2114-2127. Epub 2017 Apr 27 doi: 10.1038/npp.2017.86. PMID: 28447622Free PMC Article
Ward J
Cogn Neurosci 2015;6(2-3):45-7. doi: 10.1080/17588928.2015.1055238. PMID: 26274902
Ward J, Banissy MJ
Cogn Neurosci 2015;6(2-3):118-33. Epub 2015 May 13 doi: 10.1080/17588928.2015.1042444. PMID: 25893437

Recent systematic reviews

Di Stefano N, Spence C
Cognition 2024 Aug;249:105805. Epub 2024 May 17 doi: 10.1016/j.cognition.2024.105805. PMID: 38761646

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