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Paradoxical embolism

MedGen UID:
116043
Concept ID:
C0238096
Disease or Syndrome
Synonyms: Crossed Embolism; Crossed Embolisms; Embolism, Crossed; Embolism, Paradoxical; Embolisms, Crossed; Embolisms, Paradoxical; Paradoxical Embolism; Paradoxical Embolisms
SNOMED CT: Paradoxical embolism (134296002); Paradoxical embolus (134296002)
 
HPO: HP:0033520

Definition

Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParadoxical embolism

Professional guidelines

PubMed

Kent DM, Saver JL, Kasner SE, Nelson J, Carroll JD, Chatellier G, Derumeaux G, Furlan AJ, Herrmann HC, Jüni P, Kim JS, Koethe B, Lee PH, Lefebvre B, Mattle HP, Meier B, Reisman M, Smalling RW, Soendergaard L, Song JK, Mas JL, Thaler DE
JAMA 2021 Dec 14;326(22):2277-2286. doi: 10.1001/jama.2021.20956. PMID: 34905030Free PMC Article
Saremi F, Emmanuel N, Wu PF, Ihde L, Shavelle D, Go JL, Sánchez-Quintana D
Radiographics 2014 Oct;34(6):1571-92. doi: 10.1148/rg.346135008. PMID: 25310418
Myers PO, Bounameaux H, Panos A, Lerch R, Kalangos A
Chest 2010 Jan;137(1):164-70. Epub 2009 Jul 10 doi: 10.1378/chest.09-0961. PMID: 19592472

Recent clinical studies

Etiology

Marcucci M, Chan MTV, Smith EE, Absalom AR, Devereaux PJ
Lancet Neurol 2023 Oct;22(10):946-958. doi: 10.1016/S1474-4422(23)00209-0. PMID: 37739575
Miranda B, Fonseca AC, Ferro JM
J Neurol 2018 Aug;265(8):1943-1949. Epub 2018 Apr 21 doi: 10.1007/s00415-018-8865-0. PMID: 29680895
Mojadidi MK, Zaman MO, Elgendy IY, Mahmoud AN, Patel NK, Agarwal N, Tobis JM, Meier B
J Am Coll Cardiol 2018 Mar 6;71(9):1035-1043. doi: 10.1016/j.jacc.2017.12.059. PMID: 29495983
Fonseca AC, Ferro JM
Eur J Neurol 2015 Apr;22(4):618-23. Epub 2015 Jan 18 doi: 10.1111/ene.12673. PMID: 25597418
Windecker S, Stortecky S, Meier B
J Am Coll Cardiol 2014 Jul 29;64(4):403-15. doi: 10.1016/j.jacc.2014.04.063. PMID: 25060377

Diagnosis

Gonnah AR, Bharadwaj MS, Nassar H, Abdelaziz HK, Roberts DH
Clin Med (Lond) 2022 Sep;22(5):441-448. doi: 10.7861/clinmed.2022-0040. PMID: 36507808Free PMC Article
Ma X, Song L, Yang H, Xia J, Wu C, He Y
Ann Thorac Surg 2019 Aug;108(2):e73-e75. Epub 2019 Feb 11 doi: 10.1016/j.athoracsur.2019.01.011. PMID: 30763556
Homma S, Messé SR, Rundek T, Sun YP, Franke J, Davidson K, Sievert H, Sacco RL, Di Tullio MR
Nat Rev Dis Primers 2016 Jan 21;2:15086. doi: 10.1038/nrdp.2015.86. PMID: 27188965
Fonseca AC, Ferro JM
Eur J Neurol 2015 Apr;22(4):618-23. Epub 2015 Jan 18 doi: 10.1111/ene.12673. PMID: 25597418
Windecker S, Stortecky S, Meier B
J Am Coll Cardiol 2014 Jul 29;64(4):403-15. doi: 10.1016/j.jacc.2014.04.063. PMID: 25060377

Therapy

Kent DM, Saver JL, Kasner SE, Nelson J, Carroll JD, Chatellier G, Derumeaux G, Furlan AJ, Herrmann HC, Jüni P, Kim JS, Koethe B, Lee PH, Lefebvre B, Mattle HP, Meier B, Reisman M, Smalling RW, Soendergaard L, Song JK, Mas JL, Thaler DE
JAMA 2021 Dec 14;326(22):2277-2286. doi: 10.1001/jama.2021.20956. PMID: 34905030Free PMC Article
Spence JD
Stroke Vasc Neurol 2018 Jun;3(2):76-83. Epub 2018 Mar 9 doi: 10.1136/svn-2018-000143. PMID: 30022801Free PMC Article
Mojadidi MK, Zaman MO, Elgendy IY, Mahmoud AN, Patel NK, Agarwal N, Tobis JM, Meier B
J Am Coll Cardiol 2018 Mar 6;71(9):1035-1043. doi: 10.1016/j.jacc.2017.12.059. PMID: 29495983
Fonseca AC, Ferro JM
Eur J Neurol 2015 Apr;22(4):618-23. Epub 2015 Jan 18 doi: 10.1111/ene.12673. PMID: 25597418
Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ; Cryptogenic Stroke/ESUS International Working Group
Lancet Neurol 2014 Apr;13(4):429-38. doi: 10.1016/S1474-4422(13)70310-7. PMID: 24646875

Prognosis

Sacco S, Harriott AM, Ayata C, Ornello R, Bagur R, Jimenez-Ruiz A, Sposato LA
Neurology 2023 Apr 11;100(15):716-726. Epub 2022 Dec 15 doi: 10.1212/WNL.0000000000201699. PMID: 36522158Free PMC Article
Cai Q, Ahmad M
Echocardiography 2020 Jun;37(6):939-944. Epub 2020 May 19 doi: 10.1111/echo.14682. PMID: 32426851
Kent DM, Ruthazer R, Weimar C, Mas JL, Serena J, Homma S, Di Angelantonio E, Di Tullio MR, Lutz JS, Elkind MS, Griffith J, Jaigobin C, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papetti F, Thaler DE
Neurology 2013 Aug 13;81(7):619-25. Epub 2013 Jul 17 doi: 10.1212/WNL.0b013e3182a08d59. PMID: 23864310Free PMC Article
Furlan AJ; CLOSURE I Investigators
Stroke 2013 Jun;44(6 Suppl 1):S45-7. doi: 10.1161/STROKEAHA.113.000975. PMID: 23709727
Caplan LR
Neurology 1993 Jul;43(7):1281-7. doi: 10.1212/wnl.43.7.1281. PMID: 8327124

Clinical prediction guides

Kent DM, Saver JL, Kasner SE, Nelson J, Carroll JD, Chatellier G, Derumeaux G, Furlan AJ, Herrmann HC, Jüni P, Kim JS, Koethe B, Lee PH, Lefebvre B, Mattle HP, Meier B, Reisman M, Smalling RW, Soendergaard L, Song JK, Mas JL, Thaler DE
JAMA 2021 Dec 14;326(22):2277-2286. doi: 10.1001/jama.2021.20956. PMID: 34905030Free PMC Article
Cai Q, Ahmad M
Echocardiography 2020 Jun;37(6):939-944. Epub 2020 May 19 doi: 10.1111/echo.14682. PMID: 32426851
Miranda B, Fonseca AC, Ferro JM
J Neurol 2018 Aug;265(8):1943-1949. Epub 2018 Apr 21 doi: 10.1007/s00415-018-8865-0. PMID: 29680895
Humaidan H, Yassi N, Weir L, Davis SM, Meretoja A
J Clin Neurosci 2016 Jul;29:77-80. Epub 2016 Feb 18 doi: 10.1016/j.jocn.2015.12.015. PMID: 26898578
Kent DM, Ruthazer R, Weimar C, Mas JL, Serena J, Homma S, Di Angelantonio E, Di Tullio MR, Lutz JS, Elkind MS, Griffith J, Jaigobin C, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papetti F, Thaler DE
Neurology 2013 Aug 13;81(7):619-25. Epub 2013 Jul 17 doi: 10.1212/WNL.0b013e3182a08d59. PMID: 23864310Free PMC Article

Recent systematic reviews

Rais G, Vassallo P, Schorer R, Bollen Pinto B, Putzu A
Br J Anaesth 2022 Dec;129(6):898-908. Epub 2022 Aug 18 doi: 10.1016/j.bja.2022.06.036. PMID: 35987705
Klein J, Juratli TA, Weise M, Schackert G
World Neurosurg 2018 Jul;115:196-200. Epub 2018 Apr 26 doi: 10.1016/j.wneu.2018.04.114. PMID: 29704690
Ntaios G, Papavasileiou V, Sagris D, Makaritsis K, Vemmos K, Steiner T, Michel P
Stroke 2018 Feb;49(2):412-418. Epub 2018 Jan 15 doi: 10.1161/STROKEAHA.117.020030. PMID: 29335335
Khan R, Chan AK, Mondal TK, Paes BA; Thrombosis and Hemostasis in Newborns (THIN) Group
Eur J Paediatr Neurol 2016 Jul;20(4):500-11. Epub 2016 Apr 28 doi: 10.1016/j.ejpn.2016.04.012. PMID: 27169856
Myers PO, Bounameaux H, Panos A, Lerch R, Kalangos A
Chest 2010 Jan;137(1):164-70. Epub 2009 Jul 10 doi: 10.1378/chest.09-0961. PMID: 19592472

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