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Cerebral lymphoma

MedGen UID:
116109
•Concept ID:
C0240803
•
Neoplastic Process
Synonyms: brain primary lymphoma; Cerebral Lymphoma; cerebral lymphoma; Primary Cerebral Lymphoma; Primary cerebral lymphoma; primary cerebral lymphoma; Primary Lymphoma of Cerebrum; primary lymphoma of cerebrum; Primary Lymphoma of the Cerebrum; primary lymphoma of the cerebrum; Primary Lymphoma, Brain; primary lymphoma, brain
SNOMED CT: Primary cerebral lymphoma (276836002)
 
Monarch Initiative: MONDO:0003655

Definition

A non-Hodgkin or Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion. [from NCI]

Professional guidelines

PubMed

Management and outcome of primary CNS lymphoma in the modern era: An LOC network study.
Houillier C, Soussain C, Ghesquières H, Soubeyran P, Chinot O, Taillandier L, Lamy T, Choquet S, Ahle G, Damaj G, Agapé P, Moluçon-Chabrot C, Amiel A, Delwail V, Fabbro M, Jardin F, Chauchet A, Moles-Moreau MP, Morschhauser F, Casasnovas O, Gressin R, Fornecker LM, Abraham J, Marolleau JP, Tempescul A, Campello C, Colin P, Tamburini J, Laribi K, Serrier C, Haioun C, Chebrek S, Schmitt A, Blonski M, Houot R, Boyle E, Bay JO, Oberic L, Tabouret E, Waultier A, Martin-Duverneuil N, Touitou V, Cassoux N, Kas A, Mokhtari K, Charlotte F, Alentorn A, Feuvret L, Le Garff-Tavernier M, Costopoulos M, Mathon B, Peyre M, Delgadillo D, Douzane H, Genet D, Aidaoui B, Hoang-Xuan K, Gyan E
Neurology 2020 Mar 10;94(10):e1027-e1039. Epub 2020 Jan 6 doi: 10.1212/WNL.0000000000008900. PMID: 31907289Free PMC Article
Treatment options for Primary CNS Lymphoma.
Laghari AA, Ahmed SI, Jabbar A, Shamim MS
J Pak Med Assoc 2018 Mar;68(3):499-500. PMID: 29540898
Safety and efficacy of primary central nervous system lymphoma treatment in elderly population.
Gaviani P, Simonetti G, Innocenti A, Lamperti E, Botturi A, Silvani A
Neurol Sci 2016 Jan;37(1):131-133. Epub 2015 Aug 21 doi: 10.1007/s10072-015-2371-2. PMID: 26292791

Recent clinical studies

Etiology

Primary cerebral lymphoma' characteristics, incidence, survival, and causes of death in the United States.
Ghozy S, Dibas M, Afifi AM, Hashim MA, Abbas AS, Abdel-Daim MM, Phan K
J Neurol Sci 2020 Aug 15;415:116890. Epub 2020 May 7 doi: 10.1016/j.jns.2020.116890. PMID: 32428760
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Toxoplasmosis versus lymphoma: Cerebral lesion characterization using DSC-MRI revisited.
Dibble EH, Boxerman JL, Baird GL, Donahue JE, Rogg JM
Clin Neurol Neurosurg 2017 Jan;152:84-89. Epub 2016 Dec 2 doi: 10.1016/j.clineuro.2016.11.023. PMID: 27940418
Evolving epidemiology of malignancies in HIV.
Bonnet F, Chêne G
Curr Opin Oncol 2008 Sep;20(5):534-40. doi: 10.1097/CCO.0b013e32830a5080. PMID: 19106656

Diagnosis

Acute Disseminated Encephalomyelitis in FET PET/MR.
Lohaus N, Mader C, Jelcic I, Reimann R, Huellner MW
Clin Nucl Med 2022 Feb 1;47(2):e137-e139. doi: 10.1097/RLU.0000000000003879. PMID: 34507326
Primary cerebral lymphoma' characteristics, incidence, survival, and causes of death in the United States.
Ghozy S, Dibas M, Afifi AM, Hashim MA, Abbas AS, Abdel-Daim MM, Phan K
J Neurol Sci 2020 Aug 15;415:116890. Epub 2020 May 7 doi: 10.1016/j.jns.2020.116890. PMID: 32428760
(13)N-NH(3) PET/CT in oncological disease.
Albano D, Giubbini R, Bertagna F
Jpn J Radiol 2019 Dec;37(12):799-807. Epub 2019 Oct 10 doi: 10.1007/s11604-019-00883-7. PMID: 31599383
Brain tumors.
Herholz K, Langen KJ, Schiepers C, Mountz JM
Semin Nucl Med 2012 Nov;42(6):356-70. doi: 10.1053/j.semnuclmed.2012.06.001. PMID: 23026359Free PMC Article
Primary cerebral lymphoma.
Brown JH, Stallmeyer MJ, Lustrin ES, Chew FS
AJR Am J Roentgenol 1995 Sep;165(3):626. doi: 10.2214/ajr.165.3.7645482. PMID: 7645482

Therapy

Investigating centrifugal filtration of serum-based FTIR spectroscopy for the stratification of brain tumours.
Theakstone AG, Brennan PM, Jenkinson MD, Goodacre R, Baker MJ
PLoS One 2023;18(2):e0279669. Epub 2023 Feb 17 doi: 10.1371/journal.pone.0279669. PMID: 36800340Free PMC Article
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Optimizing therapy of seizures in patients with renal or hepatic dysfunction.
Lacerda G, Krummel T, Sabourdy C, Ryvlin P, Hirsch E
Neurology 2006 Dec 26;67(12 Suppl 4):S28-33. doi: 10.1212/wnl.67.12_suppl_4.s28. PMID: 17190918
Neurocysticercosis and acquired cerebral toxoplasmosis in children.
Mitchell WG
Semin Pediatr Neurol 1999 Dec;6(4):267-77. doi: 10.1016/s1071-9091(99)80025-4. PMID: 10649835

Prognosis

Primary cerebral lymphoma' characteristics, incidence, survival, and causes of death in the United States.
Ghozy S, Dibas M, Afifi AM, Hashim MA, Abbas AS, Abdel-Daim MM, Phan K
J Neurol Sci 2020 Aug 15;415:116890. Epub 2020 May 7 doi: 10.1016/j.jns.2020.116890. PMID: 32428760
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Brain tumors.
Herholz K, Langen KJ, Schiepers C, Mountz JM
Semin Nucl Med 2012 Nov;42(6):356-70. doi: 10.1053/j.semnuclmed.2012.06.001. PMID: 23026359Free PMC Article
Evolving epidemiology of malignancies in HIV.
Bonnet F, Chêne G
Curr Opin Oncol 2008 Sep;20(5):534-40. doi: 10.1097/CCO.0b013e32830a5080. PMID: 19106656

Clinical prediction guides

Primary cerebral lymphoma' characteristics, incidence, survival, and causes of death in the United States.
Ghozy S, Dibas M, Afifi AM, Hashim MA, Abbas AS, Abdel-Daim MM, Phan K
J Neurol Sci 2020 Aug 15;415:116890. Epub 2020 May 7 doi: 10.1016/j.jns.2020.116890. PMID: 32428760
Analysis of soluble interleukin-2 receptor as CSF biomarker for neurosarcoidosis.
Otto C, Wengert O, Unterwalder N, Meisel C, Ruprecht K
Neurol Neuroimmunol Neuroinflamm 2020 Jul;7(4) Epub 2020 May 11 doi: 10.1212/NXI.0000000000000725. PMID: 32393650Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Fluorescein sodium-guided surgery in cerebral lymphoma.
Schebesch KM, Hoehne J, Hohenberger C, Acerbi F, Broggi M, Proescholdt M, Wendl C, Riemenschneider MJ, Brawanski A
Clin Neurol Neurosurg 2015 Dec;139:125-8. Epub 2015 Sep 26 doi: 10.1016/j.clineuro.2015.09.015. PMID: 26432995
Brain tumors.
Herholz K, Langen KJ, Schiepers C, Mountz JM
Semin Nucl Med 2012 Nov;42(6):356-70. doi: 10.1053/j.semnuclmed.2012.06.001. PMID: 23026359Free PMC Article

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