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Radiation enteritis of intestine

MedGen UID:
120446
•Concept ID:
C0259795
•
Disease or Syndrome
Synonyms: Enteritis caused by radiation; Enteritis due to radiation; Inflammation of intestine caused by radiation; Radiation enteritis; Radiation Enteritis; Radiation induced enteritis
SNOMED CT: Enteritis due to radiation (73817000); Radiation enteritis (73817000); Radiation induced enteritis (73817000); Enteritis caused by radiation (73817000); Inflammation of intestine caused by radiation (73817000); Radiation enteritis of intestine (73817000)

Definition

Inflammation of the small intestine caused by radiation exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation enteritis of intestine

Professional guidelines

PubMed

Update on the management of intestinal failure.
Bharadwaj S, Tandon P, Rivas JM, Furman A, Moccia L, Ratliff A, Shatnawei A, Steiger E, Kirby DF
Cleve Clin J Med 2016 Nov;83(11):841-848. doi: 10.3949/ccjm.83a.15045. PMID: 27824535
ACR Appropriateness Criteria® Right Lower Quadrant Pain--Suspected Appendicitis.
Smith MP, Katz DS, Lalani T, Carucci LR, Cash BD, Kim DH, Piorkowski RJ, Small WC, Spottswood SE, Tulchinsky M, Yaghmai V, Yee J, Rosen MP
Ultrasound Q 2015 Jun;31(2):85-91. doi: 10.1097/RUQ.0000000000000118. PMID: 25364964
Gastrointestinal radiation injury: prevention and treatment.
Shadad AK, Sullivan FJ, Martin JD, Egan LJ
World J Gastroenterol 2013 Jan 14;19(2):199-208. doi: 10.3748/wjg.v19.i2.199. PMID: 23345942Free PMC Article

Recent clinical studies

Etiology

Radiation enteritis: Diagnostic and therapeutic issues.
Loge L, Florescu C, Alves A, Menahem B
J Visc Surg 2020 Dec;157(6):475-485. Epub 2020 Sep 1 doi: 10.1016/j.jviscsurg.2020.08.012. PMID: 32883650
ESPEN guidelines on chronic intestinal failure in adults.
Pironi L, Arends J, Bozzetti F, Cuerda C, Gillanders L, Jeppesen PB, Joly F, Kelly D, Lal S, Staun M, Szczepanek K, Van Gossum A, Wanten G, Schneider SM; Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of ESPEN
Clin Nutr 2016 Apr;35(2):247-307. Epub 2016 Feb 8 doi: 10.1016/j.clnu.2016.01.020. PMID: 26944585
Severe acute diarrhea.
Gore JI, Surawicz C
Gastroenterol Clin North Am 2003 Dec;32(4):1249-67. doi: 10.1016/s0889-8553(03)00100-6. PMID: 14696306Free PMC Article
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037
Radiation-induced intestinal injury.
Nussbaum ML, Campana TJ, Weese JL
Clin Plast Surg 1993 Jul;20(3):573-80. PMID: 8324995

Diagnosis

Unrecognized digestive toxicities of radiation therapy.
Camprodon G, Huguet F
Cancer Radiother 2021 Oct;25(6-7):723-728. Epub 2021 Aug 11 doi: 10.1016/j.canrad.2021.07.007. PMID: 34391649
Radiation enteritis: Diagnostic and therapeutic issues.
Loge L, Florescu C, Alves A, Menahem B
J Visc Surg 2020 Dec;157(6):475-485. Epub 2020 Sep 1 doi: 10.1016/j.jviscsurg.2020.08.012. PMID: 32883650
Intestinal fibrosis.
Lenti MV, Di Sabatino A
Mol Aspects Med 2019 Feb;65:100-109. Epub 2018 Nov 2 doi: 10.1016/j.mam.2018.10.003. PMID: 30385174
Chronic radiation enteritis.
Chater C, Saudemont A, Zerbib P
J Visc Surg 2019 Apr;156(2):175-176. Epub 2018 Sep 22 doi: 10.1016/j.jviscsurg.2018.09.002. PMID: 30249429
Radiation enteritis.
Yeoh EK, Horowitz M
Surg Gynecol Obstet 1987 Oct;165(4):373-9. PMID: 3310287

Therapy

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy.
Zhang D, Zhong D, Ouyang J, He J, Qi Y, Chen W, Zhang X, Tao W, Zhou M
Nat Commun 2022 Mar 17;13(1):1413. doi: 10.1038/s41467-022-28744-4. PMID: 35301299Free PMC Article
Radiation enteritis: Diagnostic and therapeutic issues.
Loge L, Florescu C, Alves A, Menahem B
J Visc Surg 2020 Dec;157(6):475-485. Epub 2020 Sep 1 doi: 10.1016/j.jviscsurg.2020.08.012. PMID: 32883650
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy.
Anderson PM, Lalla RV
Nutrients 2020 Jun 4;12(6) doi: 10.3390/nu12061675. PMID: 32512833Free PMC Article
ESPEN guidelines on chronic intestinal failure in adults.
Pironi L, Arends J, Bozzetti F, Cuerda C, Gillanders L, Jeppesen PB, Joly F, Kelly D, Lal S, Staun M, Szczepanek K, Van Gossum A, Wanten G, Schneider SM; Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of ESPEN
Clin Nutr 2016 Apr;35(2):247-307. Epub 2016 Feb 8 doi: 10.1016/j.clnu.2016.01.020. PMID: 26944585
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037

Prognosis

Microbiome and Abdominopelvic Radiotherapy Related Chronic Enteritis: A Microbiome-based Mechanistic Role of Probiotics and Antibiotics.
Giridhar P, Pradhan S, Dokania S, Venkatesulu B, Sarode R, Welsh JS
Am J Clin Oncol 2024 May 1;47(5):246-252. Epub 2024 Jan 9 doi: 10.1097/COC.0000000000001082. PMID: 38193365
Unrecognized digestive toxicities of radiation therapy.
Camprodon G, Huguet F
Cancer Radiother 2021 Oct;25(6-7):723-728. Epub 2021 Aug 11 doi: 10.1016/j.canrad.2021.07.007. PMID: 34391649
The Potential Effects of Radiation on the Gut-Brain Axis.
Jones CB, Davis CM, Sfanos KS
Radiat Res 2020 Mar;193(3):209-222. Epub 2020 Jan 3 doi: 10.1667/RR15493.1. PMID: 31898468
Radiation-induced intestinal damage: latest molecular and clinical developments.
Lu L, Li W, Chen L, Su Q, Wang Y, Guo Z, Lu Y, Liu B, Qin S
Future Oncol 2019 Dec;15(35):4105-4118. Epub 2019 Nov 20 doi: 10.2217/fon-2019-0416. PMID: 31746639
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037

Clinical prediction guides

REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Zhu X, Li Y, Tian X, Jing Y, Wang Z, Yue L, Li J, Wu L, Zhou X, Yu Z, Zhang Y, Guan F, Yang M, Zhang B
Am J Pathol 2024 Jun;194(6):975-988. Epub 2024 Feb 27 doi: 10.1016/j.ajpath.2024.02.008. PMID: 38423356
Establishment of a prediction model for severe acute radiation enteritis associated with cervical cancer radiotherapy.
Ma CY, Zhao J, Gan GH, He XL, Xu XT, Qin SB, Wang LL, Li L, Zhou JY
World J Gastroenterol 2023 Feb 28;29(8):1344-1358. doi: 10.3748/wjg.v29.i8.1344. PMID: 36925455Free PMC Article
Endoscopic findings of radiation ileitis.
Hokama A
Rev Esp Enferm Dig 2023 Mar;115(3):144. doi: 10.17235/reed.2022.9036/2022. PMID: 35791788
Paediatric magnetic resonance enterography in inflammatory bowel disease.
Greer MC
Eur J Radiol 2018 May;102:129-137. Epub 2018 Mar 7 doi: 10.1016/j.ejrad.2018.02.029. PMID: 29685526
Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.
Shea-Donohue T, Sun R, Bohl JA, McLean LP, Zhao A
Cytokine 2015 Sep;75(1):62-7. Epub 2015 Jul 15 doi: 10.1016/j.cyto.2015.06.007. PMID: 26188364

Recent systematic reviews

The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review.
Wang L, Wang X, Zhang G, Ma Y, Zhang Q, Li Z, Ran J, Hou X, Geng Y, Yang Z, Feng S, Li C, Zhao X
Radiat Oncol 2021 Sep 25;16(1):187. doi: 10.1186/s13014-021-01899-y. PMID: 34563216Free PMC Article
Magnetic resonance imaging in pediatric appendicitis: a systematic review.
Moore MM, Kulaylat AN, Hollenbeak CS, Engbrecht BW, Dillman JR, Methratta ST
Pediatr Radiol 2016 May;46(6):928-39. Epub 2016 May 26 doi: 10.1007/s00247-016-3557-3. PMID: 27229509
Systematic review: MRI enterography for assessment of small bowel involvement in paediatric Crohn's disease.
Giles E, Barclay AR, Chippington S, Wilson DC
Aliment Pharmacol Ther 2013 Jun;37(12):1121-31. Epub 2013 May 3 doi: 10.1111/apt.12323. PMID: 23638954

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