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Hemophilic arthropathy

MedGen UID:: 120487
•Concept ID:: C0263725
•: Disease or Syndrome

Synonyms:	arthropathy in haemophilia; Arthropathy in hemophilia; arthropathy in hemophilia; Hemophilic arthritis; Hemophilic Arthritis; hemophilic arthritis; hemophilic arthropathy
SNOMED CT:	Arthropathy in hemophilia (80813006); Hemophilic arthritis (80813006); Hemophilic arthropathy (80813006)

Monarch Initiative:	MONDO:0043240

Definition

A form of arthritis that affects hemophiliacs, which is characterized by bleeding into the joint space. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHemophilic arthropathy

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Abnormal joint morphology
        Arthritis
        Hemophilic arthropathy

Professional guidelines

PubMed

Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis.

Norooznezhad F, Rodriguez-Merchan EC, Asadi S, Norooznezhad AH
Expert Rev Hematol 2020 Jan;13(1):5-11. Epub 2019 Oct 30 doi: 10.1080/17474086.2020.1685867. PMID: 31657968

Management of Hemophilic Arthropathy of the Ankle.

Rodriguez-Merchan EC
Cardiovasc Hematol Disord Drug Targets 2017;17(2):111-118. doi: 10.2174/1871529X17666170908110758. PMID: 28891453

Hemophilic arthropathy of the elbow: prophylaxis, imaging, and the role of invasive management.

Dale TM, Saucedo JM, Rodríguez-Merchán EC
J Shoulder Elbow Surg 2015 Oct;24(10):1669-78. doi: 10.1016/j.jse.2015.06.018. PMID: 26385390

See all (38)

Recent clinical studies

Etiology

Hemophilic arthropathy: Current knowledge and future perspectives.

Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690 Free PMC Article

Risks and patient outcomes of surgical intervention for hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2019 May;12(5):325-333. Epub 2019 Apr 14 doi: 10.1080/17474086.2019.1602035. PMID: 30929534

A history of prophylaxis in haemophilia.

Moreno MM, Cuesta-Barriuso R
Blood Coagul Fibrinolysis 2019 Mar;30(2):55-57. doi: 10.1097/MBC.0000000000000783. PMID: 30507712

Current role for radioisotope synovectomy.

André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100

Bacterial arthritis.

Ho G Jr
Curr Opin Rheumatol 1992 Aug;4(4):509-15. PMID: 1503874

See all (158)

Diagnosis

Soft Tissue Pathology.

Shane AM, Reeves CL, Nguyen GB, Ferrise TD, Calaj PM
Clin Podiatr Med Surg 2023 Jul;40(3):381-395. Epub 2023 Apr 28 doi: 10.1016/j.cpm.2023.02.003. PMID: 37236677

Hemophilic arthropathy: Current knowledge and future perspectives.

Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690 Free PMC Article

Hemophilic Arthropathy.

Nacca CR, Harris AP, Tuttle JR
Orthopedics 2017 Nov 1;40(6):e940-e946. Epub 2017 Jun 30 doi: 10.3928/01477447-20170619-05. PMID: 28662249

Advances and challenges in hemophilic arthropathy.

Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902 Free PMC Article

Synovium and cartilage biomarkers in hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

See all (110)

Therapy

Chronic pain in patients with hemophilia: is it preventable?

Visweshwar N, Zhang Y, Joseph H, Jaglal M, Ayala I
Blood Coagul Fibrinolysis 2020 Sep;31(6):346-352. doi: 10.1097/MBC.0000000000000939. PMID: 32815911

Risks and patient outcomes of surgical intervention for hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2019 May;12(5):325-333. Epub 2019 Apr 14 doi: 10.1080/17474086.2019.1602035. PMID: 30929534

A history of prophylaxis in haemophilia.

Moreno MM, Cuesta-Barriuso R
Blood Coagul Fibrinolysis 2019 Mar;30(2):55-57. doi: 10.1097/MBC.0000000000000783. PMID: 30507712

Pathophysiology of the disturbed angiogenesis in hemophilia.

Rodriguez-Merchan EC
Expert Rev Hematol 2016 Oct;9(10):933-8. Epub 2016 Sep 22 doi: 10.1080/17474086.2016.1234933. PMID: 27624637

Hemophilic arthropathy.

Luck JV Jr, Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS
J Am Acad Orthop Surg 2004 Jul-Aug;12(4):234-45. doi: 10.5435/00124635-200407000-00004. PMID: 15473675

See all (109)

Prognosis

Cytokines in the pathogenesis of hemophilic arthropathy.

Wojdasiewicz P, Poniatowski ŁA, Nauman P, Mandat T, Paradowska-Gorycka A, Romanowska-Próchnicka K, Szukiewicz D, Kotela A, Kubaszewski Ł, Kotela I, Kurkowska-Jastrzębska I, Gasik R
Cytokine Growth Factor Rev 2018 Feb;39:71-91. Epub 2017 Nov 13 doi: 10.1016/j.cytogfr.2017.11.003. PMID: 29153709

Current role for radioisotope synovectomy.

André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100

Pathophysiology of hemophilic arthropathy and potential targets for therapy.

Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816

Advances and challenges in hemophilic arthropathy.

Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902 Free PMC Article

Synovium and cartilage biomarkers in hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

See all (78)

Clinical prediction guides

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T(2) Mapping.

Majeed H, Ahmed H, Sussman MS, Macgowan C, Rayner T, Weiss R, Feldman BM, Doria AS
J Magn Reson Imaging 2021 Mar;53(3):827-837. Epub 2020 Nov 2 doi: 10.1002/jmri.27406. PMID: 33135834

Pathophysiology of hemophilic arthropathy and potential targets for therapy.

Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816

Advances and challenges in hemophilic arthropathy.

Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902 Free PMC Article

Synovium and cartilage biomarkers in hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

Hemophilic arthropathy: a review of imaging and staging.

Cross S, Vaidya S, Fotiadis N
Semin Ultrasound CT MR 2013 Dec;34(6):516-24. doi: 10.1053/j.sult.2013.05.007. PMID: 24332203

See all (128)

Recent systematic reviews

Efficacy of rehabilitation interventions on functioning in patients with hemophilic arthropathy: A systematic review with meta-analysis.

Lippi L, de Sire A, Turco A, Santi RM, Polverelli M, Ammendolia A, Follenzi A, Invernizzi M
J Back Musculoskelet Rehabil 2024;37(4):853-870. doi: 10.3233/BMR-230320. PMID: 38578880

The Efficacy of Physical Therapy Modalities in Patients With Hemophilia: A Systematic Review of Randomized Controlled Trials With Meta-analysis.

Elshennawy S, Zahreldin AA, Mortada H, Hozien M, Youssef ASA, Galal A, Shahien M, Elfeky A, Elaraby A, Hamed M
Arch Phys Med Rehabil 2023 Mar;104(3):475-489. Epub 2022 Jul 19 doi: 10.1016/j.apmr.2022.05.023. PMID: 35868453

Total Knee Arthroplasty in Hemophilia: Survivorship and Outcomes-A Systematic Review and Meta-Analysis.

Fenelon C, Murphy EP, Fahey EJ, Murphy RP, O'Connell NM, Queally JM
J Arthroplasty 2022 Mar;37(3):581-592.e1. Epub 2021 Oct 28 doi: 10.1016/j.arth.2021.10.015. PMID: 34756977

Biochemical marker research in hemophilic arthropathy: A systematic review.

van Bergen EDP, van Vulpen LFD, Schutgens REG, Mastbergen SC, Lafeber FPJG
Blood Rev 2021 May;47:100781. Epub 2020 Nov 22 doi: 10.1016/j.blre.2020.100781. PMID: 33277057

Synovium and cartilage biomarkers in hemophilic arthropathy.

Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

See all (8)

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Hemophilic arthropathy

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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