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MISSED ABORTION

MedGen UID:
1260
•Concept ID:
C0000814
•
Disease or Syndrome
Synonyms: Abortion, Missed; Abortions, Missed; Missed Abortion; Missed Abortions
SNOMED CT: MA - Missed abortion (16607004); Silent miscarriage (16607004); Missed miscarriage (16607004); Missed abortion (16607004)

Definition

Retention in uterus of an abortus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • MISSED ABORTION

Professional guidelines

PubMed

Ultrasound Evaluation of First Trimester Complications of Pregnancy.
Morin L, Cargill YM, Glanc P
J Obstet Gynaecol Can 2016 Oct;38(10):982-988. doi: 10.1016/j.jogc.2016.06.001. PMID: 27720100
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Management of early pregnancy loss.
Graziosi GC, Mol BW, Ankum WM, Bruinse HW
Int J Gynaecol Obstet 2004 Sep;86(3):337-46. doi: 10.1016/j.ijgo.2004.04.038. PMID: 15325850

Recent clinical studies

Etiology

Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Thyrotoxicosis and pregnancy.
Perros P
PLoS Med 2005 Dec;2(12):e370. Epub 2005 Dec 27 doi: 10.1371/journal.pmed.0020370. PMID: 16363909Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Diagnosis

Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Hysteroscopy for infertile women: a review.
Cholkeri-Singh A, Sasaki KJ
J Minim Invasive Gynecol 2015 Mar-Apr;22(3):353-62. Epub 2014 Dec 29 doi: 10.1016/j.jmig.2014.12.163. PMID: 25553895
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486
Ovarian hyperstimulation syndrome.
Schenker JG, Polishuk WZ
Obstet Gynecol 1975 Jul;46(1):23-8. doi: 10.1097/00006250-197507000-00004. PMID: 1153133

Therapy

Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Misoprostol and pregnancy.
Goldberg AB, Greenberg MB, Darney PD
N Engl J Med 2001 Jan 4;344(1):38-47. doi: 10.1056/NEJM200101043440107. PMID: 11136959
Spontaneous abortion.
Boyd ME
Can J Surg 1989 Jul;32(4):260-4. PMID: 2660972
Ovarian hyperstimulation syndrome.
Schenker JG, Polishuk WZ
Obstet Gynecol 1975 Jul;46(1):23-8. doi: 10.1097/00006250-197507000-00004. PMID: 1153133

Prognosis

High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
Lin H, Gao L, Huang Y
Immunol Invest 2023 Nov;52(8):997-1007. Epub 2023 Nov 24 doi: 10.1080/08820139.2023.2279653. PMID: 37933581
Female reproductive tract microbiome and early miscarriages.
Lebedeva OP, Popov VN, Syromyatnikov MY, Starkova NN, Maslov AY, Kozarenko ON, Gryaznova MV
APMIS 2023 Feb;131(2):61-76. Epub 2023 Jan 2 doi: 10.1111/apm.13288. PMID: 36511842Free PMC Article
"See and treat" hysteroscopy after missed abortion.
Kuzel D, Horak P, Hrazdirova L, Kubinova K, Sosna O, Mara M
Minim Invasive Ther Allied Technol 2011 Jan;20(1):14-7. Epub 2010 Aug 10 doi: 10.3109/13645706.2010.496999. PMID: 20695832
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486
Spontaneous abortion.
Boyd ME
Can J Surg 1989 Jul;32(4):260-4. PMID: 2660972

Clinical prediction guides

High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
Lin H, Gao L, Huang Y
Immunol Invest 2023 Nov;52(8):997-1007. Epub 2023 Nov 24 doi: 10.1080/08820139.2023.2279653. PMID: 37933581
Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q
Fertil Steril 2023 Mar;119(3):492-503. Epub 2022 Dec 15 doi: 10.1016/j.fertnstert.2022.12.016. PMID: 36528108
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion.
Gulic T, Laskarin G, Dominovic M, Glavan Gacanin L, Babarović E, Rubesa Z, Haller H, Rukavina D
Am J Reprod Immunol 2018 Sep;80(3):e12978. Epub 2018 May 18 doi: 10.1111/aji.12978. PMID: 29774968
Plasma metabolomic profile and potential biomarkers for missed abortion.
Fei H, Hou J, Wu Z, Zhang L, Zhao H, Dong X, Chen Y
Biomed Chromatogr 2016 Dec;30(12):1942-1952. Epub 2016 Jul 7 doi: 10.1002/bmc.3770. PMID: 27229294

Recent systematic reviews

Diagnostic value of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio to predict recurrent pregnancy loss and abortion; a systematic review and meta-analysis.
Hantoushzadeh S, Gargar OK, Jafarabady K, Rezaei MM, Asadi F, Eshraghi N, Panahi Z, Shirdel S, Mirzamoradi M, Ghaemi M
Immun Inflamm Dis 2024 Mar;12(3):e1210. doi: 10.1002/iid3.1210. PMID: 38506423Free PMC Article
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis.
Wu HL, Marwah S, Wang P, Wang QM, Chen XW
Sci Rep 2017 May 10;7(1):1664. doi: 10.1038/s41598-017-01892-0. PMID: 28490770Free PMC Article
A systematic review of validated methods to capture stillbirth and spontaneous abortion using administrative or claims data.
Likis FE, Sathe NA, Carnahan R, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K74-82. doi: 10.1016/j.vaccine.2013.03.076. PMID: 24331077

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