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Acanthamoeba keratitis

MedGen UID:
1268
•Concept ID:
C0000880
•
Disease or Syndrome
Synonyms: Acanthamoeba Keratitides; Acanthamoeba Keratitis; Keratitides, Acanthamoeba; Keratitis, Acanthamoeba
SNOMED CT: Acanthamoeba keratitis (231896005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005629
Orphanet: ORPHA67043

Definition

A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcanthamoeba keratitis
Follow this link to review classifications for Acanthamoeba keratitis in Orphanet.

Professional guidelines

PubMed

Diagnosis and treatment of Acanthamoeba Keratitis: A scoping review demonstrating unfavorable outcomes.
Büchele MLC, Nunes BF, Filippin-Monteiro FB, Caumo KS
Cont Lens Anterior Eye 2023 Aug;46(4):101844. Epub 2023 Apr 26 doi: 10.1016/j.clae.2023.101844. PMID: 37117130
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Recent clinical studies

Etiology

Opioid Prescribing Patterns for Ulcerative Keratitis.
Thibodeau AR, Niziol LM, Tannen BL, Ballouz D, Woodward MA
Cornea 2022 Apr 1;41(4):484-490. doi: 10.1097/ICO.0000000000002893. PMID: 34620771Free PMC Article
Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes.
Maycock NJ, Jayaswal R
Cornea 2016 May;35(5):713-20. doi: 10.1097/ICO.0000000000000804. PMID: 26989955
Infections with free-living amebae.
Visvesvara GS
Handb Clin Neurol 2013;114:153-68. doi: 10.1016/B978-0-444-53490-3.00010-8. PMID: 23829906
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Diagnosis

Infectious keratitis: A review.
Cabrera-Aguas M, Khoo P, Watson SL
Clin Exp Ophthalmol 2022 Jul;50(5):543-562. Epub 2022 Jun 3 doi: 10.1111/ceo.14113. PMID: 35610943Free PMC Article
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Ocular cytology: Diagnostic features and ongoing practices.
Laver NMV
Cancer Cytopathol 2021 Jun;129(6):419-431. Epub 2020 Nov 2 doi: 10.1002/cncy.22384. PMID: 33136340
Infectious corneal ulcers.
Farahani M, Patel R, Dwarakanathan S
Dis Mon 2017 Feb;63(2):33-37. Epub 2016 Dec 22 doi: 10.1016/j.disamonth.2016.09.003. PMID: 28017285
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Therapy

Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Development of anti-acanthamoebic approaches.
Mungroo MR, Tong T, Khan NA, Anuar TS, Maciver SK, Siddiqui R
Int Microbiol 2021 Aug;24(3):363-371. Epub 2021 Mar 23 doi: 10.1007/s10123-021-00171-3. PMID: 33754231
Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment.
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Prognosis

Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach.
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones.
Ahmed U, Ho KY, Simon SE, Saad SM, Ong SK, Anwar A, Tan KO, Sridewi N, Khan KM, Khan NA, Anwar A
Acta Trop 2022 Jul;231:106440. Epub 2022 Apr 1 doi: 10.1016/j.actatropica.2022.106440. PMID: 35378058
Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes.
Maycock NJ, Jayaswal R
Cornea 2016 May;35(5):713-20. doi: 10.1097/ICO.0000000000000804. PMID: 26989955
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900
Acanthamoeba sclerokeratitis.
Dougherty PJ, Binder PS, Mondino BJ, Glasgow BJ
Am J Ophthalmol 1994 Apr 15;117(4):475-9. doi: 10.1016/s0002-9394(14)70007-8. PMID: 8154529

Clinical prediction guides

Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones.
Ahmed U, Ho KY, Simon SE, Saad SM, Ong SK, Anwar A, Tan KO, Sridewi N, Khan KM, Khan NA, Anwar A
Acta Trop 2022 Jul;231:106440. Epub 2022 Apr 1 doi: 10.1016/j.actatropica.2022.106440. PMID: 35378058
Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors.
Roozbahani M, Hammersmith KM, Rapuano CJ, Nagra PK, Zhang Q
Int Ophthalmol 2019 Dec;39(12):2889-2896. Epub 2019 Jun 18 doi: 10.1007/s10792-019-01137-1. PMID: 31214859
Epidemiology, risk factors, and clinical outcomes in severe microbial keratitis in South India.
Chidambaram JD, Venkatesh Prajna N, Srikanthi P, Lanjewar S, Shah M, Elakkiya S, Lalitha P, Burton MJ
Ophthalmic Epidemiol 2018 Aug;25(4):297-305. Epub 2018 Mar 26 doi: 10.1080/09286586.2018.1454964. PMID: 29580152Free PMC Article
Experimental infection of T4 Acanthamoeba genotype determines the pathogenic potential.
Alves Dde S, Moraes AS, Alves LM, Gurgel-Gonçalves R, Lino Junior Rde S, Cuba-Cuba CA, Vinaud MC
Parasitol Res 2016 Sep;115(9):3435-40. Epub 2016 May 11 doi: 10.1007/s00436-016-5105-3. PMID: 27164833
Medical interventions for acanthamoeba keratitis.
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article

Recent systematic reviews

Diagnostic accuracy of confocal scan in detecting acanthamoeba keratitis and fungal keratitis: a systematic review and meta-analysis.
Moshtaghion SM, Abolhosseini M, Yaseri M, Hosseini SB, Kanavi MR
Int Ophthalmol 2023 Aug;43(8):3011-3022. Epub 2023 Mar 28 doi: 10.1007/s10792-023-02689-z. PMID: 36977847
Genotype distribution of Acanthamoeba in keratitis: a systematic review.
Diehl MLN, Paes J, Rott MB
Parasitol Res 2021 Sep;120(9):3051-3063. Epub 2021 Aug 5 doi: 10.1007/s00436-021-07261-1. PMID: 34351492Free PMC Article
Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.
Ting DSJ, Henein C, Said DG, Dua HS
Sci Rep 2021 Jun 21;11(1):13007. doi: 10.1038/s41598-021-92366-x. PMID: 34155280Free PMC Article
Medical interventions for acanthamoeba keratitis.
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article
New approach to diagnosis and treatment of Acanthamoeba keratitis--systematic review of literature.
Kokot J, Dobrowolski D, Lyssek-Boroń A, Milka M, Smedowski A, Wójcik Ł, Wowra B, Wyligała E
Klin Oczna 2012;114(4):311-6. PMID: 23461162

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