U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult acute monocytic leukemia

MedGen UID:
128856
•Concept ID:
C0280634
•
Neoplastic Process
Synonyms: acute monocytic leukaemia of adults; acute monocytic leukemia of adults; adult acute differentiated monocytic leukaemia (M5b); Adult Acute Differentiated Monocytic Leukemia (M5b); adult acute differentiated monocytic leukemia (M5b); Adult Acute Monocytic Leukemia; adult acute monocytic leukemia; M5b adult acute differentiated monocytic leukaemia; M5b Adult Acute Differentiated Monocytic Leukemia; M5b adult acute differentiated monocytic leukemia; M5b adult acute leukaemia; M5b Adult Acute Leukemia; M5b adult acute leukemia
 
Monarch Initiative: MONDO:0000875

Definition

An acute monocytic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult acute monocytic leukemia

Professional guidelines

PubMed

Myelomonocytic and monocytic acute myeloid leukemia demonstrate comparable poor outcomes with venetoclax-based treatment: a monocentric real-world study.
Zhao L, Yang J, Chen M, Xiang X, Ma H, Niu T, Gong Y, Chen X, Liu J, Wu Y
Ann Hematol 2024 Apr;103(4):1197-1209. Epub 2024 Feb 8 doi: 10.1007/s00277-024-05646-7. PMID: 38329487
LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia.
Anami Y, Deng M, Gui X, Yamaguchi A, Yamazaki CM, Zhang N, Zhang CC, An Z, Tsuchikama K
Mol Cancer Ther 2020 Nov;19(11):2330-2339. Epub 2020 Sep 2 doi: 10.1158/1535-7163.MCT-20-0407. PMID: 32879051Free PMC Article
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article

Recent clinical studies

Therapy

Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia.
Sourdeau E, Suner L, Memoli M, Genthon A, Feger F, Soret L, Abermil N, Heuberger L, Bilhou-Nabera C, Guermouche H, Favale F, Lapusan S, Chaquin M, Hirschauer C, Mohty M, Legrand O, Delhommeau F, Hirsch P
Haematologica 2023 Jan 1;108(1):61-68. doi: 10.3324/haematol.2022.280676. PMID: 35924580Free PMC Article
Neutrophilic Eccrine Hidradenitis.
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Treatment-related acute granulocyte-monocytic leukemia from multiple myeloma: A case report and literature review.
Qian J, Shi W, Yang L, Lin Z, Cai Y, Liu H
Medicine (Baltimore) 2017 Dec;96(50):e9293. doi: 10.1097/MD.0000000000009293. PMID: 29390389Free PMC Article
Concomitant Cutaneous Langerhans Cell Hystiocytosis and Leukemia Cutis.
Pina-Oviedo S, Torres-Cabala CA, Miranda RN, Tetzlaff MT, Singh S, Rapini RP, Prieto VG, Aung PP
Am J Dermatopathol 2017 May;39(5):388-392. doi: 10.1097/DAD.0000000000000775. PMID: 27759701
Aleukemic leukemia cutis.
Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y
J Am Acad Dermatol 1990 Feb;22(2 Pt 2):374-7. doi: 10.1016/0190-9622(90)70052-j. PMID: 2406302

Prognosis

RAD21 mutations in acute myeloid leukemia.
Laczko D, Poveda-Rogers C, Matthews AH, Snaith O, Luger S, Bagg A, Caponetti GC, Morrissette JJD, Yang G
Leuk Lymphoma 2024 Jul;65(7):958-964. Epub 2024 Mar 20 doi: 10.1080/10428194.2024.2328233. PMID: 38506144
Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia.
Sourdeau E, Suner L, Memoli M, Genthon A, Feger F, Soret L, Abermil N, Heuberger L, Bilhou-Nabera C, Guermouche H, Favale F, Lapusan S, Chaquin M, Hirschauer C, Mohty M, Legrand O, Delhommeau F, Hirsch P
Haematologica 2023 Jan 1;108(1):61-68. doi: 10.3324/haematol.2022.280676. PMID: 35924580Free PMC Article
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Cytogenetics and associated mutation profile in patients with acute monocytic leukemia.
Xing S, Wang B, Gao Y, Li M, Wang T, Sun Y, Shen Y, Chao H
Int J Lab Hematol 2019 Aug;41(4):485-492. Epub 2019 May 17 doi: 10.1111/ijlh.13030. PMID: 31099482
Role of HOTAIR in the diagnosis and prognosis of acute leukemia.
Zhang YY, Huang SH, Zhou HR, Chen CJ, Tian LH, Shen JZ
Oncol Rep 2016 Dec;36(6):3113-3122. Epub 2016 Oct 4 doi: 10.3892/or.2016.5147. PMID: 27748863Free PMC Article

Clinical prediction guides

Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia.
Sourdeau E, Suner L, Memoli M, Genthon A, Feger F, Soret L, Abermil N, Heuberger L, Bilhou-Nabera C, Guermouche H, Favale F, Lapusan S, Chaquin M, Hirschauer C, Mohty M, Legrand O, Delhommeau F, Hirsch P
Haematologica 2023 Jan 1;108(1):61-68. doi: 10.3324/haematol.2022.280676. PMID: 35924580Free PMC Article
IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias.
Katz SG, Edappallath S, Xu ML
Am J Surg Pathol 2021 Oct 1;45(10):1391-1398. doi: 10.1097/PAS.0000000000001765. PMID: 34172624
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Role of HOTAIR in the diagnosis and prognosis of acute leukemia.
Zhang YY, Huang SH, Zhou HR, Chen CJ, Tian LH, Shen JZ
Oncol Rep 2016 Dec;36(6):3113-3122. Epub 2016 Oct 4 doi: 10.3892/or.2016.5147. PMID: 27748863Free PMC Article
Early mortality in acute myeloid leukemia.
Hahn A, Giri S, Yaghmour G, Martin MG
Leuk Res 2015 May;39(5):505-9. Epub 2015 Feb 9 doi: 10.1016/j.leukres.2015.02.003. PMID: 25726083

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...