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Childhood Acute Myeloid Leukemia with Minimal Differentiation

MedGen UID:
129065
•Concept ID:
C0281642
•
Neoplastic Process
Synonyms: Childhood Acute M0 Leukemia; Childhood Acute Minimally Differentiated Myeloid Leukemia; Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Myeloid Leukemia Minimally Differentiated; M0 Childhood Acute Minimally Differentiated Myeloid Leukemia; M0 Pediatric Acute Minimally Differentiated Myeloid Leukemia; Pediatric Acute M0 Leukemia; Pediatric Acute Minimally Differentiated Myeloid Leukemia

Definition

An acute myeloid leukemia with minimal differentiation occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Myeloid Leukemia with Minimal Differentiation

Recent clinical studies

Etiology

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia.
McGinnis E, Yang D, Au N, Morrison D, Chipperfield KM, Setiadi AF, Liu L, Tsang A, Vercauteren SM
Cytometry B Clin Cytom 2021 Jul;100(4):446-453. Epub 2020 Oct 13 doi: 10.1002/cyto.b.21966. PMID: 33048471
Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data.
Xie S, Hossain MJ
Cancer Epidemiol 2018 Jun;54:19-24. Epub 2018 Mar 16 doi: 10.1016/j.canep.2018.03.001. PMID: 29554538Free PMC Article
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.
Hossain MJ, Xie L, Caywood EH
Cancer Epidemiol 2015 Oct;39(5):720-6. Epub 2015 Jul 6 doi: 10.1016/j.canep.2015.06.009. PMID: 26159683Free PMC Article
Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia.
Roman E, Cooney E, Harrison L, Militano O, Wolownik K, Hawks R, Foley S, Satwani P, Unal E, Bhatia M, Bradley B, Del Toro G, George D, Garvin J, van de Ven C, Cairo MS
Clin Cancer Res 2005 Oct 1;11(19 Pt 2):7164s-7170s. doi: 10.1158/1078-0432.CCR-1004-0018. PMID: 16203817
Preleukemia. Cytogenetic clues in some confusing disorders.
Nowell PC
Am J Pathol 1977 Nov;89(2):459-76. PMID: 335894Free PMC Article

Diagnosis

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia.
McGinnis E, Yang D, Au N, Morrison D, Chipperfield KM, Setiadi AF, Liu L, Tsang A, Vercauteren SM
Cytometry B Clin Cytom 2021 Jul;100(4):446-453. Epub 2020 Oct 13 doi: 10.1002/cyto.b.21966. PMID: 33048471
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.
Hovorkova L, Zaliova M, Venn NC, Bleckmann K, Trkova M, Potuckova E, Vaskova M, Linhartova J, Machova Polakova K, Fronkova E, Muskovic W, Giles JE, Shaw PJ, Cario G, Sutton R, Stary J, Trka J, Zuna J
Blood 2017 May 18;129(20):2771-2781. Epub 2017 Mar 22 doi: 10.1182/blood-2016-11-749978. PMID: 28331056
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.
Hossain MJ, Xie L, Caywood EH
Cancer Epidemiol 2015 Oct;39(5):720-6. Epub 2015 Jul 6 doi: 10.1016/j.canep.2015.06.009. PMID: 26159683Free PMC Article
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cavé H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, González M, Viehmann S, Malec M, Saglio G, van Dongen JJ
Leukemia 2003 Dec;17(12):2318-57. doi: 10.1038/sj.leu.2403135. PMID: 14562125
Preleukemia. Cytogenetic clues in some confusing disorders.
Nowell PC
Am J Pathol 1977 Nov;89(2):459-76. PMID: 335894Free PMC Article

Therapy

The TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia: Results of the TACL T2009-008 phase I study.
Ronsley R, Kariminia A, Ng B, Mostafavi S, Reid G, Subrt P, Hijiya N, Schultz KR
Pediatr Hematol Oncol 2019 Nov;36(8):468-481. Epub 2019 Sep 18 doi: 10.1080/08880018.2019.1667461. PMID: 31530240
Granulocyte colony stimulating factor increases drug resistance of leukaemic blast cells to daunorubicin.
Márkász L, Hajas G, Kiss A, Lontay B, Rajnavölgyi E, Erdodi F, Oláh E
Pathol Oncol Res 2008 Sep;14(3):285-92. Epub 2008 May 21 doi: 10.1007/s12253-008-9057-5. PMID: 18493867
Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia.
Roman E, Cooney E, Harrison L, Militano O, Wolownik K, Hawks R, Foley S, Satwani P, Unal E, Bhatia M, Bradley B, Del Toro G, George D, Garvin J, van de Ven C, Cairo MS
Clin Cancer Res 2005 Oct 1;11(19 Pt 2):7164s-7170s. doi: 10.1158/1078-0432.CCR-1004-0018. PMID: 16203817
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cavé H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, González M, Viehmann S, Malec M, Saglio G, van Dongen JJ
Leukemia 2003 Dec;17(12):2318-57. doi: 10.1038/sj.leu.2403135. PMID: 14562125

Prognosis

Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data.
Xie S, Hossain MJ
Cancer Epidemiol 2018 Jun;54:19-24. Epub 2018 Mar 16 doi: 10.1016/j.canep.2018.03.001. PMID: 29554538Free PMC Article
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.
Hossain MJ, Xie L, Caywood EH
Cancer Epidemiol 2015 Oct;39(5):720-6. Epub 2015 Jul 6 doi: 10.1016/j.canep.2015.06.009. PMID: 26159683Free PMC Article
Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.
Riedt T, Ebinger M, Salih HR, Tomiuk J, Handgretinger R, Kanz L, Grünebach F, Lengerke C
Blood 2009 Apr 23;113(17):4049-51. Epub 2009 Feb 13 doi: 10.1182/blood-2008-12-196634. PMID: 19218548
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cavé H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, González M, Viehmann S, Malec M, Saglio G, van Dongen JJ
Leukemia 2003 Dec;17(12):2318-57. doi: 10.1038/sj.leu.2403135. PMID: 14562125
Preleukemia. Cytogenetic clues in some confusing disorders.
Nowell PC
Am J Pathol 1977 Nov;89(2):459-76. PMID: 335894Free PMC Article

Clinical prediction guides

Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data.
Xie S, Hossain MJ
Cancer Epidemiol 2018 Jun;54:19-24. Epub 2018 Mar 16 doi: 10.1016/j.canep.2018.03.001. PMID: 29554538Free PMC Article
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.
Hovorkova L, Zaliova M, Venn NC, Bleckmann K, Trkova M, Potuckova E, Vaskova M, Linhartova J, Machova Polakova K, Fronkova E, Muskovic W, Giles JE, Shaw PJ, Cario G, Sutton R, Stary J, Trka J, Zuna J
Blood 2017 May 18;129(20):2771-2781. Epub 2017 Mar 22 doi: 10.1182/blood-2016-11-749978. PMID: 28331056
Clinical significance of immunophenotypic markers in pediatric T-cell acute lymphoblastic leukemia.
Sidhom I, Shaaban K, Soliman S, Ezzat S, El-Anwar W, Hamdy N, Yassin D, Salem S, Hassanein H, Mansour MT
J Egypt Natl Canc Inst 2008 Jun;20(2):111-20. PMID: 20029466
Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia.
Roman E, Cooney E, Harrison L, Militano O, Wolownik K, Hawks R, Foley S, Satwani P, Unal E, Bhatia M, Bradley B, Del Toro G, George D, Garvin J, van de Ven C, Cairo MS
Clin Cancer Res 2005 Oct 1;11(19 Pt 2):7164s-7170s. doi: 10.1158/1078-0432.CCR-1004-0018. PMID: 16203817
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cavé H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, González M, Viehmann S, Malec M, Saglio G, van Dongen JJ
Leukemia 2003 Dec;17(12):2318-57. doi: 10.1038/sj.leu.2403135. PMID: 14562125

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