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Benign meningioma

MedGen UID:: 129095
•Concept ID:: C0281784
•: Neoplastic Process

Synonyms:	Benign Meningioma; Benign Meningiomas; Meningioma, Benign; Meningiomas, Benign
SNOMED CT:	Benign meningioma (724171006); Benign meningioma (1157019008)

Monarch Initiative:	MONDO:0003054

Definition

A grade I, slowly growing meningioma. Only a minority of tumors recur following complete resection. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign meningioma

Disorder by Site
- Disorder of nervous system
  - Disorder of the central nervous system
    - Neoplasm of the central nervous system
      - Primary Central Nervous System Neoplasm
        Benign neoplasm of meninges
        Benign meningioma
        Benign Intracranial Meningioma

Professional guidelines

PubMed

Geriatric brain tumor management part I: Meningioma.

Cohen-Inbar O
J Clin Neurosci 2019 Sep;67:5-9. Epub 2019 Jun 14 doi: 10.1016/j.jocn.2019.05.063. PMID: 31208835

Review of controversies in management of non-benign meningioma.

Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209

Diagnosis and treatment of atypical and anaplastic meningiomas: a review.

Modha A, Gutin PH
Neurosurgery 2005 Sep;57(3):538-50; discussion 538-50. doi: 10.1227/01.neu.0000170980.47582.a5. PMID: 16145534

See all (16)

Recent clinical studies

Etiology

Location pattern of recurrence of fully resected grade 1 meningiomas.

Ong K, Rizzuto M, Makarenko S
Acta Neurochir (Wien) 2023 Oct;165(10):2865-2871. Epub 2023 Aug 24 doi: 10.1007/s00701-023-05758-5. PMID: 37620597

Cause-Specific Survival After Meningioma Surgery: A Nationwide Population-Based Competing Risk Study.

Champeaux-Depond C, Constantinou P, Weller J
World Neurosurg 2021 Feb;146:e67-e75. Epub 2020 Oct 20 doi: 10.1016/j.wneu.2020.10.012. PMID: 33096279

Peritumoral Brain Edema and Surgical Outcome in Secretory Meningiomas: A Matched-Cohort Analysis.

Trivedi MM, Worley S, Raghavan A, Das P, Recinos PF, Barnett GH, Kshettry VR
World Neurosurg 2021 Jan;145:e170-e176. Epub 2020 Oct 3 doi: 10.1016/j.wneu.2020.09.151. PMID: 33022430

Differentiating meningioma grade by imaging features on magnetic resonance imaging.

Hale AT, Wang L, Strother MK, Chambless LB
J Clin Neurosci 2018 Feb;48:71-75. Epub 2017 Nov 22 doi: 10.1016/j.jocn.2017.11.013. PMID: 29174756

Radiosurgical treatment of meningiomas.

Zamorano L, Saenz A, Matter A, Buciuc R, Gaspar L, Fontanesi J, Garzon A, Diaz F
Stereotact Funct Neurosurg 1997;69(1-4 Pt 2):156-61. doi: 10.1159/000099869. PMID: 9711750

See all (98)

Diagnosis

Location pattern of recurrence of fully resected grade 1 meningiomas.

Ong K, Rizzuto M, Makarenko S
Acta Neurochir (Wien) 2023 Oct;165(10):2865-2871. Epub 2023 Aug 24 doi: 10.1007/s00701-023-05758-5. PMID: 37620597

Differentiating meningioma grade by imaging features on magnetic resonance imaging.

Hale AT, Wang L, Strother MK, Chambless LB
J Clin Neurosci 2018 Feb;48:71-75. Epub 2017 Nov 22 doi: 10.1016/j.jocn.2017.11.013. PMID: 29174756

Fractal Analysis May Improve the Preoperative Identification of Atypical Meningiomas.

Czyz M, Radwan H, Li JY, Filippi CG, Tykocki T, Schulder M
Neurosurgery 2017 Feb 1;80(2):300-308. doi: 10.1093/neuros/nyw030. PMID: 28173535

Granulofilamentous meningioma.

Miyajima Y, Oka H, Utsuki S, Hagiwara H, Inukai M, Kijima C, Hara A, Yasui Y, Kawano N, Fujii K
Brain Tumor Pathol 2013 Jan;30(1):57-60. Epub 2012 Mar 2 doi: 10.1007/s10014-012-0091-3. PMID: 22382610

Radiosurgical treatment of meningiomas.

Zamorano L, Saenz A, Matter A, Buciuc R, Gaspar L, Fontanesi J, Garzon A, Diaz F
Stereotact Funct Neurosurg 1997;69(1-4 Pt 2):156-61. doi: 10.1159/000099869. PMID: 9711750

See all (90)

Therapy

KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.

Jungwirth G, Yu T, Cao J, Eddine MA, Moustafa M, Warta R, Debus J, Unterberg A, Abdollahi A, Herold-Mende C
Cancer Lett 2021 May 28;506:1-10. Epub 2021 Feb 27 doi: 10.1016/j.canlet.2021.02.016. PMID: 33652084

Gamma Knife radiosurgery for intracranial benign meningiomas: follow-up outcome in 130 patients.

Ge Y, Liu D, Zhang Z, Li Y, Lin Y, Wang G, Zong Y, Liu E
Neurosurg Focus 2019 Jun 1;46(6):E7. doi: 10.3171/2019.3.FOCUS1956. PMID: 31153153

Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients.

Fokas E, Henzel M, Surber G, Hamm K, Engenhart-Cabillic R
Int J Radiat Oncol Biol Phys 2014 Jul 1;89(3):569-75. Epub 2014 Apr 18 doi: 10.1016/j.ijrobp.2014.02.042. PMID: 24751409

Advances in meningioma therapy.

Norden AD, Drappatz J, Wen PY
Curr Neurol Neurosci Rep 2009 May;9(3):231-40. doi: 10.1007/s11910-009-0034-5. PMID: 19348712

Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy.

Wenkel E, Thornton AF, Finkelstein D, Adams J, Lyons S, De La Monte S, Ojeman RG, Munzenrider JE
Int J Radiat Oncol Biol Phys 2000 Dec 1;48(5):1363-70. doi: 10.1016/s0360-3016(00)01411-5. PMID: 11121635

See all (45)

Prognosis

KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.

Cause-Specific Survival After Meningioma Surgery: A Nationwide Population-Based Competing Risk Study.

Champeaux-Depond C, Constantinou P, Weller J
World Neurosurg 2021 Feb;146:e67-e75. Epub 2020 Oct 20 doi: 10.1016/j.wneu.2020.10.012. PMID: 33096279

Differentiating meningioma grade by imaging features on magnetic resonance imaging.

Hale AT, Wang L, Strother MK, Chambless LB
J Clin Neurosci 2018 Feb;48:71-75. Epub 2017 Nov 22 doi: 10.1016/j.jocn.2017.11.013. PMID: 29174756

The transmembrane chemokines CXCL16 and CX3CL1 and their receptors are expressed in human meningiomas.

Li G, Hattermann K, Mentlein R, Mehdorn HM, Held-Feindt J
Oncol Rep 2013 Feb;29(2):563-70. Epub 2012 Dec 3 doi: 10.3892/or.2012.2164. PMID: 23229614

Radiosurgical treatment of meningiomas.

Zamorano L, Saenz A, Matter A, Buciuc R, Gaspar L, Fontanesi J, Garzon A, Diaz F
Stereotact Funct Neurosurg 1997;69(1-4 Pt 2):156-61. doi: 10.1159/000099869. PMID: 9711750

See all (89)

Clinical prediction guides

Cause-Specific Survival After Meningioma Surgery: A Nationwide Population-Based Competing Risk Study.

Champeaux-Depond C, Constantinou P, Weller J
World Neurosurg 2021 Feb;146:e67-e75. Epub 2020 Oct 20 doi: 10.1016/j.wneu.2020.10.012. PMID: 33096279

Differentiating meningioma grade by imaging features on magnetic resonance imaging.

Hale AT, Wang L, Strother MK, Chambless LB
J Clin Neurosci 2018 Feb;48:71-75. Epub 2017 Nov 22 doi: 10.1016/j.jocn.2017.11.013. PMID: 29174756

Fractal Analysis May Improve the Preoperative Identification of Atypical Meningiomas.

Czyz M, Radwan H, Li JY, Filippi CG, Tykocki T, Schulder M
Neurosurgery 2017 Feb 1;80(2):300-308. doi: 10.1093/neuros/nyw030. PMID: 28173535

Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients.

Fokas E, Henzel M, Surber G, Hamm K, Engenhart-Cabillic R
Radiother Oncol 2014 Jun;111(3):457-62. Epub 2014 May 8 doi: 10.1016/j.radonc.2014.04.003. PMID: 24813096

Metabolic aggressiveness in benign meningiomas with chromosomal instabilities.

Monleón D, Morales JM, Gonzalez-Segura A, Gonzalez-Darder JM, Gil-Benso R, Cerdá-Nicolás M, López-Ginés C
Cancer Res 2010 Nov 1;70(21):8426-34. Epub 2010 Sep 21 doi: 10.1158/0008-5472.CAN-10-1498. PMID: 20861191

See all (75)

Recent systematic reviews

Role of adjuvant radiotherapy in atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas: a systematic review.

Delgado-López PD, Corrales-García EM
Clin Transl Oncol 2021 Feb;23(2):205-221. Epub 2020 Jul 10 doi: 10.1007/s12094-020-02434-3. PMID: 32651886

Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline.

Marchetti M, Sahgal A, De Salles AAF, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh JH, Yomo S, Fariselli L
Neurosurgery 2020 Oct 15;87(5):879-890. doi: 10.1093/neuros/nyaa169. PMID: 32463867 Free PMC Article

Proton therapy for treatment of intracranial benign tumors in adults: A systematic review.

Lesueur P, Calugaru V, Nauraye C, Stefan D, Cao K, Emery E, Reznik Y, Habrand JL, Tessonnier T, Chaikh A, Balosso J, Thariat J
Cancer Treat Rev 2019 Jan;72:56-64. Epub 2018 Dec 1 doi: 10.1016/j.ctrv.2018.11.004. PMID: 30530009

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Benign meningioma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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